摘要：Objec.ive: The purpose of this study was to investigate the effec. of raloxifene on leptin and insulin-like growth fac.or- I levels and their relation with the bioc.emic.l markers of bone metabolism in postmenopausal women. Study design: Sixty-four women were given 60 mg/d raloxifene for 6 months. Serum leptin, insulin-like growth fac.or- I, alkaline phosphatase, c.lc.um, osteoc.lc.n, and c.llagen type I c.oss-link c.telopeptide levels were measured before and after the treatment. The patients were grouped as obese (body mass index, ≥ 25 kg/m2) or non-obese (body mass index, < 25 kg/m2). Results: The mean basal leptin level was signific.ntly higher (P < .001), and the mean c.osslink c.telopeptide level was signific.ntly lower (P = .001) in obese patients. Raloxifene therapy inc.eased leptin levels (P < .001) and dec.eased insulin-like growth fac.or- I, alkaline phosphatase, and c.oss-link c.telopeptide levels signific.ntly (P < .001). There was a strong negative c.rrelation between leptin and c.oss-link c.telopeptide (r = - 0.703; P < .001). Insulin-like growth fac.or- I was not c.rrelated with any parameter. c.nc.usion: Raloxifene inc.eases serum leptin levels while dec.easing bone resorption in postmenopausal women.