摘要：For unconstrained optimization, a new hybrid projection algorithm is presented m the paper. This algorithm has some attractive convergence properties. Convergence theory can be obtained under the condition that Δ↓f（x） is uniformly continuous. If Δ↓f（x） is continuously differentiable pseudo-convex, the whole sequence of iterates converges to a solution of the problem without any other assumptions. Furthermore, under appropriate conditions one shows that the sequence of iterates has a cluster-point if and only if Ω＊ ≠ θ. Numerical examples are given at the end of this paper.

摘要：With rapid spread of HIV(human immunodeficiency virus) on a global scale and increasingly severe drug-resistance of it,it is urgently necessary to develop novel effective anti-HIV ***-nucleoside reverse transcriptase inhibitor(NNRTIs)is one of the most significant antiretroviral drugs for fighting against HIV infection due to their various structures,unique mode of action,good efficacy and low *** derivatives,a type of NNRTIs,have been reported to achieve remarkable development in the past few *** this review,we summarized current drug design and medicinal chemistry efforts toward the development of next-generation pyridinones as HIV-1 NNRTIs.

摘要：A topological structural design approach is presented which is based upon the implementation of a two phase evolutionary optimization algorithm in conjunction with a finite element analysis code. The first phase utilizes a conventional genetic approach which performs a global search for the optimal design topology. Dual level material properties are specified within the genetic encoding and are applied to each individual element in the design mesh to represent either design material or a void. The second phase introduces a rule based refinement which allows for user design intent to accelerate the solution process and eliminate obvious design discrepancies resulting from the phase one search. A series of plate design problems are presented where the objective is to minimize the overall volume of the structure under predefined loading and constraint conditions. The constraints include both stress and deflection considerations where stress is calculated through the use of a commercial finite element package. The initial plate example incorporates a coarse mesh, but a gradual decrease in element size was employed for the remaining cases examined. Replacement of the phase one search with a set of randomly generated designs is demonstrated in order to form a greatly reduced design space which drastically increases the efficiency of the solution process. Comparison results are drawn between the conventional genetic algorithm and the two phase procedure.

摘要：目的:对清热润湿方的提取工艺进行优化并进行临床药效评价。方法:采用响应面法对提取工艺进行试验设计与研究,选择指标性成分小檗碱、黄芩苷、栀子苷的含量和干浸膏得率以及体外药效学指标MDA、IL-6、TNF-α作为检测指标,通过归一化法处理数据后加权计算并进行综合评价,通过计算分析模拟预测最优提取工艺并验证。在此基础上进一步比较工艺优化前后药物的临床疗效,确认优化的合理性与有效性。结果:最优提取工艺为10倍加水量、煎煮118 min、煎煮3次;优化后的药物疗效在创面评价(P<0.01)、疼痛评价(P<0.05)、舒适度评价(P<0.05)3个临床指标上均有改善。结论:通过响应面法优化的清热润湿方的提取工艺稳定有效,临床疗效显著提升。

摘要：In the present study,novel ester derivatives of CAPE were designed and synthesized as neuroprotective *** anti-inflammatory and antioxidant activities of these compounds were evaluated at the cellular level,while the blood-brain barrier(BBB)permeability was predicted by parallel artificial membrane permeability assay(PAMPA).The results revealed that phenolic hydroxyl groups and double bonds in the structure of CAPE had important effects on neuroprotective ***,a preliminary structure-activity relationship was summarized in this *** addition,we observed a significant improvement on BBB *** results provided important references for the structural modification and optimization of CAPE in the future.

摘要：本文重点论述了《二十四诗品》这种新颖独特的艺术表现方式在晚唐的产生、形成与前人的诗歌创作、诗歌理论背景及司空图自身的诗文创作之间内在密不可分的联系。司空图于其诗论中也提出了一系列对后代影响深远的美学命题,本文力图将其置于古代文学理论演进的背景之中,对司空图的诗歌思想进行较为深入细致的探讨。

摘要：随着大数据时代的到来,全球数据总量爆炸式增长。由于理论储存密度极高、保存时间长等天然优势,DNA被认为可以对海量数据提供稳定、低成本的存储。自概念提出以来,DNA存储技术在编解码算法、数据恢复及重复性读取等核心方面取得进展。但难以想象基于生物分子DNA的信息存储技术如何实现大规模、稳定的数字信息存储,任何报道的DNA信息存储原型系统的存储能力都与实际信息存储需求间存在巨大鸿沟。因此,DNA分子实现实用信息存储,除了需要解决最为核心的合成成本问题外,仍缺乏对存储不同文件的DNA进行稳定保存及高度集成的技术,并且面临海量数据存储时,需要为DNA文库设计适当索引实现特定文件检索,以及存在DNA生物分子存储设备如何与现有电子系统对接等问题。聚焦保存方式对DNA的物理存储密度和文件检索方式的影响,并介绍了文件检索方式以及自动化设备的开发的研究进展,以期促进物理存储密度高、文件选择性检索便捷的集成化DNA存储系统的开发,从而促进DNA数据存储的商业应用。

摘要：陆机在其文学理论著作《文赋》中就诔文这种哀祭文的特色提出了“诔缠绵而凄怆”的文学主张。《文选》五臣注济曰:“诔叙哀情,故缠绵意密而凄怆悲心也。”现代学者对这一主张也作出了进一步的诠释,认为这反映了诔的功能在西晋已从官样文章的“述德”向表达个人情感、“寄托哀情”的方向转化,陆机于此提倡用诔文抒发真情实感。《愍怀太子诔》是陆机诔文中篇幅最长,而且最为后人所称道的一篇作品。本文试图通过集中分析这篇名作来探讨以上观点,讨论陆机对诔文创作特点的发展,他的文学主张与文学创作之间的紧密联系,并说明他如何成功地在西晋王朝形势严峻的政治舞台上,用其文学才能充分展示表达哀伤的艺术。

摘要：Supersaturated designs （SSDs） have been widely used in factor screening experiments. The present paper aims to prove that the maximal balanced designs are a kind of special optimal SSDs under the E（fNOD） criterion. We also propose a new method, called the complementary design method, for constructing E（fNoD） optimal SSDs. The basic principle of this method is that for any existing E（fNOD） optimal SSD whose E（fNOD） value reaches its lower bound, its complementary design in the corresponding maximal balanced design is also E（fNOD） optimal. This method applies to both symmetrical and asymmetrical （mixed-level） cases. It provides a convenient and efl：icient way to construct many new designs with relatively large numbers of factors. Some newly constructed designs are given as examples.

摘要：为了进一步降低传统耦合装置的加工成本和制作时间,提升水导激光耦合装置的加工质量和效率性能,根据水导激光微细加工的工作原理,设计出了环形凹槽和等距柱型流道结构的新型耦合装置。通过SolidWorks软件构建轴对称射流水腔的三维数值模型,并用ANSYS Fluent软件对其进行数值模拟流场仿真,分析了水腔内部速度矢量图、流线图和射流出口处气液两相流仿真图。结果表明:在进水口径8 mm、入口速度1 m/s、喷口口径0. 25 mm的设置条件下,水导激光耦合装置各个剖面的速度矢量平稳、紧密,喷口处水流均衡稳定、无波动。该耦合装置结构设计合理可靠,完全能够满足水导激光微细加工设计和使用要求。