摘要：A series of α,β-unsaturated ketone derivatives were synthesized, and their anti-inflammatory activity toward NLRP3 inflammasome was evaluated in vitro. Several compounds were identified as anti-inflammatory agents, among which compound A21 exhibited potent anti-inflammatory activity in a dose-dependent manner with an IC50）of 0.95 μM. Moreover, a preliminary structure-activity relationship was also summarized.

摘要：非球面反射镜通常使用零位补偿器配合干涉仪进行面形检测,因此零位补偿器的加工和装配精度直接决定了检测结果的可靠性。提出一种具备良好通用性的基于计算全息片(CGH)的补偿器误差标定方法。以一块Φ856 mm、f/1.54的双曲面反射镜作为待测非球面镜,首先设计反射式CGH,运用光线追迹法得到CGH的相位函数,使其引入的球差与待测非球面主镜的法线像差相同,再由ZEMAX仿真计算验证该设计的正确性,并根据相位函数加工出主全息。在同一块玻璃基片上设计和加工对准全息带用于标定光路的调整。实验结果表明,所制作的CGH标定零位补偿器的精度达到λ/80。可见对于大口径、快焦比的凹非球面反射镜,所提方法仍然适用,因此可用于指导多数正轴非球面镜的零位补偿器标定。