摘要：Tissue engineering approaches,including those to functional lung tissues,are finely honed by the inclusion of upgraded devices that mimic biophysical and biochemical features in *** culture is one of these essential biophysical characteristics enabled by the introduction of microfluidic devices in recent *** review links the importance of dynamic culture for in vitro maintenance of functional lung cells to the modeling of respiratory *** identify and discuss different parameters for fabricating the requisite microfluidic models for lung cells,as well as their application in modeling lung diseases caused by external factors such as smoking and *** possibility of creating a multi-organ-on-a-chip to establish a more physiologically relevant model is ***,the focus is on different prospects for the in vitro modeling approach and for lungs-on-a-chip for developing advanced,reliable technology to analyze the pathophysiology of respiratory diseases and screen potential treatments.