摘要：Bac.ground: Ablative skin resurfac.ng with c.rbon dioxide (c.2) and erbium:YA G lasers is still c.nsidered the gold standard for treating rhytides, photodamag e, and ac.e sc.rs. However, the prolonged downtime and undesired c.nc.mitant eff ec.s that are involved have sent dermatologists looking for less invasive nonabl ative laser tec.niques to rejuvenate skin. Objec.ive: To c.mbine c.ld-air c.ol ing with single-pass c.2 laser skin resurfac.ng to generate as muc. benefit as possible while minimizing the spec.rum of adverse effec.s. Study Design: The ef fic.c. of single-pass c.2 laser skin resurfac.ng on perioral and periorbital w rinkles was examined prospec.ively during a 6- month follow-up period. In a s ide-by-side c.mparison, the influenc. of simultaneous c.ld-air c.oling on c.nc.mitant effec.s, pain toleranc., therapeutic.suc.ess, and patient satisfac.i on was also studied. Eight patients with perioral and/or periorbital wrinkles un derwent the proc.dure. During laser treatment, only the right half of eac. fac.w as c.oled using a c.ld-air system. Results: Six months after treatment, a mild improvement of the wrinkles was observed in all c.ses. The use of c.ld-air c. oling did not have any impac. on the longterm results, although in a direc. c.mp arison between sides, it was observed that