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摘要:Biological stimuli-responsive polymers have increasingly attracted attention in recent years because it can satisfy many requirements of applications related with human body while traditional systems do not *** to the importance of this burgeoning field,great efforts have been devoted and,up to now,polymer chemists have made a remarkable success in this prospective research *** this review,we systematically generalize the present state of biological stimuli-responsive polymer *** highlight several representative examples to specify the current problems and look ahead a clear sense of direction in this area.
摘要:针对可能由不确定干扰和网络攻击引起的通信链路故障的航天器编队控制系统,提出一种基于零和微分博弈的最优容错控制方法.该方法通过构建描述编队协同控制的性能函数,将通信链路故障容错控制问题等效转换为零和微分博弈模型.采用Hamilton-Jacobi-Isaacs(HJI)方程和极小极大原则设计博弈中的优化解,并利用自适应动态规划算法对其进行在线逼近,以获得编队的最优容错控制策略,保证航天器通信链路故障下的在轨稳定性和最优性能.仿真结果表明了本文设计的分布式最优容错控制律的有效性.
摘要:提出了一种工作于太赫兹频段的双频微带天线。通过在天线辐射贴片上加载双T型辐射缝隙,改变天线表面电流的路径来实现双频特性。对天线模型进行了仿真分析,仿真结果表明,所设计天线的谐振频率分别为300和670GHz,最大增益达到了7.13dB。该双频天线结构简单、易于加工且性能指标稳定,可应用于太赫兹通信系统中,其设计方法对双频微带天线的设计有一定的参考价值。
摘要:目的设计和构建特异性siRNA纳米载体SWCNT-siRNA,通过体外实验,研究其对脑胶质瘤的作用。方法设计合成特异性Bcl-2 siRNA,利用超声技术合成SWCNT-siRNA复合物,动态散射粒度分析仪进行粒径分析;体外培养U251胶质瘤细胞,SWCNT-siRNA复合物处理细胞后,激光共聚焦显微镜追踪siRNA进入细胞的分布。PCR检测靶基因Bcl-2沉默情况,Annexin-V FITC与PI联合标记细胞后,流式细胞仪检测细胞凋亡。结果通过粒径分析证明siRNA成功缠绕到SWCNT上形成稳定的复合物siRNA-SWCNT。利用激光共聚焦显微镜对标记红色荧光的siRNA进行追踪,发现siRNA成功投递到细胞内。PCR验证了被投递到胞浆的siRNA很好的沉默目标基因Bcl-2。通过流式细胞仪分析发现,与对照组比较发现其可以抑制肿瘤细胞生长,促进肿瘤细胞早期凋亡。结论 SWCNT作为纳米载体投递Bcl-2 siRNA进入U251胶质瘤细胞,通过降解Bcl-2 mRNA抑制Bcl-2的表达并促进胶质瘤细胞的凋亡。
摘要:TiAl合金具有轻质、耐高温、高强的优点,在航空航天领域具有良好的应用前景。然而,室温塑性低、加工成型能力不足,限制了其广泛应用。组织细化是提高TiAl合金性能的主要途径和当前研究热点。形变热处理将变形与热处理工艺结合,可以显著细化组织、大幅改善性能。本文综述了TiAl合金的形变热处理技术,系统阐述了形变热处理对合金多尺度结构细化和综合力学性能提升的作用原理及规律,为TiAl合金设计、工艺制定、工程化应用提供参考指导。
摘要:We propose a new 3D inversion scheme to invert the near-and transition-zone data of CSAMT with topography *** this new method,the earth was discretized into unstructured tetrahedra to fit the ragged topography and the vector fi nite-element method was adopted to obtain precise responses and good *** simulate the attitude and shape of the transmitter,we divided a long-grounded transmitter into dipoles and integrated these dipoles to obtain good responses in the near-and transition-fi eld ***,we designed an L2 norm-based objective functional and applied a standard quasi-Newton method as the optimization method to solve the inverse problem and guarantee steady *** tested our 3D inversion method first on synthetic data and then on a field dataset acquired from select sites near Changbai Mountain,*** both tests,the new inversion algorithm achieved excellent fitting between the predicted and observed data,even in near-and transition-fi eld zones,and the inversion results agreed well with the true *** fi ndings reveal that the proposed algorithm is eff ective for 3D inversion of CSAMT data.
摘要:In order to discover new molecules with good insecticidal activities, a series of anthranilic diamides containing polyfluoroalkyl pyrazole were designed and synthesized, and their structures were characterized by1 H NMR and HRMS. Bioassays demonstrated that some of the title compound exhibited excellent insecticidal activities. The larvicidal activities of compound 8a, 8c, 8g, 8k and 8l against Mythimna separata Walker were 100% at 0.8 mg/L. The insecticidal activities of compound 8a, 8c,8e, 8g, 8k and 8l against Plutella xylostella Linnaeus were 100% at 0.4 mg/L. Surprisingly compounds 8a and 8c still showed 100% larvicidal activities against Plutella xylostella Linnaeus at 0.08 mg/L comparable to the commercialized Chlorantraniliprole. The LC_(50) of compound 8a and 8c against M. separata is 0.048 and 0.043 mg/L respectively.
摘要:针对对地观测卫星系统顶层设计中存在的仿真耗时、设计空间大以及非线性约束的特点,在其优化的不同阶段构建了试验设计的应用框架:优化初期采用正交设计方法确定系统的关键性能参数,中期采用均匀设计或拉丁方设计生成仿真方案并依此进行数值仿真,后期通过稳健设计考虑系统的噪声因素,保证最终方案的鲁棒性。该框架可以缩小对地观测卫星系统的仿真规模、缩短仿真时间、提高优化效率,保证解的质量,最后通过一个实例对优化框架的效果进行了验证。
摘要:针对内置式永磁同步电动机在螺旋桨重载工况下,两相静止坐标系滑模观测器中扩展反电动势幅值大小易受螺旋桨负载影响的问题,在两相旋转坐标系下设计一种新型滑模观测器用以实现内置式永磁电动机转速及转子位置观测。采用李雅普诺夫稳定性理论对所设计的滑模观测器进行了稳定性分析,得出电动机转速估算表达式,避免了扩展反电动势的观测。对所提出的永磁同步电动机无速度传感器控制策略进行仿真分析和试验研究,结果表明设计的滑模观测器能够准确实现永磁电动机的转速估算,系统具有良好的动态响应性能,验证了该控制策略的有效性与可行性。
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