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Design, Synthesis and Inhibitory Properties against Coxsackie B3/B6 of Some Novel Triazole Derivatives: 收藏
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引用; 《International Journal of Organic Chemistry》2013年第1期3卷 41-46页; 作者：Dongping Shao Yanbing Yang Fei Xue Xianjin Luo reyila wubulikasimu Yuhuan Li Rongmei Gao Weidong YeInstitute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai China Zhejiang Medicine Co. Ltd. Xinchang Pharmaceutical Factory Xinchang China; A series of 1,2,4-triazole derivatives were synthesized, and their abilities to inhibit the in vitro replication of Coxsackie B3/B6 were evaluated. Among the 1,2,4-triazole derivatives, compound 3 g displayed potent a...; A series of 1,2,4-triazole derivatives were synthesized, and their abilities to inhibit the in vitro replication of Coxsackie B3/B6 were evaluated. Among the 1,2,4-triazole derivatives, compound 3 g displayed potent activity, with a high antiviral potency (IC50 = 1.71 μM (against CVB3), 1.43 μM (against CVB6)). The structures of all the new synthesized compounds were confirmed by 1H-NMR spectra, mass spectra and elemental analyses.; 来源：详细信息评论

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