摘要：The repair of osteochondral defects is one of the major clinical challenges in ***-established osteochondral tissue engineering methods have shown promising results for the early treatment of small ***,less success has been achieved for the regeneration of large defects,which is mainly due to the mechanical environment of the joint and the heterogeneous nature of the *** this study,we developed a multi-layered osteochondral scaffold to match the heterogeneous nature of osteochondral tissue by harnessing additive manufacturing technologies and combining the established art laser sintering and material extrusion *** developed scaffold is based on a titanium and polylactic acid matrix-reinforced collagen“sandwich”composite *** microstructure and mechanical properties of the scaffold were examined,and its safety and efficacy in the repair of large osteochondral defects were tested in an ovine condyle *** 12-week in vivo evaluation period revealed extensive and significantly higher bone in-growth in the multi-layered scaffold compared with the collagen–HAp scaffold,and the achieved stable mechanical fixation provided strong support to the healing of the overlying cartilage,as demonstrated by hyaline-like cartilage *** histological examination showed that the regenerated cartilage in the multi-layer scaffold group was superior to that formed in the control *** genes such as aggrecan and collagen-II were upregulated in the scaffold and were higher than those in the control *** findings showed the safety and efficacy of the cell-free“translation-ready”osteochondral scaffold,which has the potential to be used in a one-step surgical procedure for the treatment of large osteochondral defects.

摘要：在工程规划设计实践中,如何更好地创造出健康的生活空间和居住环境及其具体应用方法作初步的分析论述,以求更好地促进人类健康居住环境的建设规划与可持续发展。

摘要：以目前国内普通住宅常见户型进行分析, 探讨住宅户型及功能创新设计的一些实用方法。

摘要：对适用于轴对称双燃烧室冲压发动机的亚燃模块进气道非设计点工作特性进行了风洞实验和数值计算研究,获得了该进气道的非设计点性能,并分析了其流态特征和再起动特性。实验数据显示,该进气道的马赫数4临界状态性能为:总压恢复系数0.425,出口截面平均马赫数0.519,可承受反压为自由流静压的56.52倍,而马赫数5的相应临界性能参数则分别为0.240,0.486和125.94。非设计状态下,该进气道的流量系数下降显著,马赫数5时的流量系数为0.813,马赫数4时则进一步下降至0.593,为此对高超声速进气道非设点综合性能的改善迫在眉睫。另外,该进气道在马赫数4时具有再起动能力。

摘要：以红土镍尾矿和页岩为原料制备烧结墙体材料.分别对原材料的性质进行了测试分析,研究了红土镍尾矿掺量、成型含水率、烧结制度对烧结制品性能的影响,并对烧结机理进行了阐述分析.结果表明,红土镍尾矿的最佳掺量为40％,最佳成型含水率为18％,最佳烧结温度为1050～1100℃,保温时间为1.0～1.5h,中试产品符合国家相关标准要求.

摘要：研究了植被型多孔混凝土的配合比设计方法及其制备工艺,配制出不同的种植基进行植生试验。结果表明,当包裹粗骨料的浆体流动度为180～210mm时,采用绝对体积法能够有效计算出植被型多孔混凝土的配合比;在制备工艺上探索出一种"预包裹"技术,采用4步搅拌工序和振捣与加压相结合的成型方式;由膨润土、营养土、珍珠岩、花生肤与种子等按一定比例混合而成的种植基,采取渗透方法填充多孔混凝土内部孔隙,再加上相应的养护与管理,完全能使植物在其上面茁壮成长。