摘要：The keratoprosthesis(KPro;artificial cornea)is a special refractive device to replace human cornea by using heterogeneous forming materials for the implantation into the damaged eyes in order to obtain a certain *** main problems of artificial cornea are the biocompatibility and stability of the tissue particularly in penetrating *** current studies of tissue-engineered scaffold materials through comprising composites of natural and synthetic biopolymers together have developed a new way to artificial *** a wide agreement that the long-term stability of these devices would be greatly improved by the presence of cornea cells,modification of keratoprosthesis to support cornea cells remains *** of the studies on corneal substrate materials and surface modification of composites have tried to improve the growth and biocompatibility of cornea cells which can not only reduce the stimulus of heterogeneous materials,but also more importantly continuous and stable cornea cells can prevent the destruction of *** necrosis of stroma and spontaneous extrusion of the device,allow for maintenance of a precorneal tear layer,and play the role of ensuring a good optical surface and resisting bacterial *** a result,improvement in corneal cells has been the main aim of several recent investigations;some effort has focused on biomaterial for its well biological properties such as promoting the growth of cornea *** purpose of this review is to summary the growth status of the corneal cells after the implantation of several artificial corneas.

摘要：为推动喷射混凝土的高性能化和高耐久性发展,进行了喷射混凝土的力学性能和微观结构试验研究。试验结果表明,与基准喷射混凝土相比,各类喷射混凝土的抗压强度、抗折强度、弹性模量均有所降低。但PVA玻璃纤维喷射混凝土的抗拉强度增幅最大,相比AR玻璃纤维喷射混凝土,PVA纤维喷射混凝土表现出更优异的抗拉性能。纤维素喷射混凝土的微观孔结构性能改善最优。综合考虑,PVA喷射混凝土更适合应用于实际的喷射混凝土工程。

摘要：为快速精准检测猫冠状病毒(FCoV),用FCoV的7b基因设计引物与探针,构建重组酶聚合酶扩增-侧流层析试纸条(RPA-LFD)方法。通过筛选最佳反应时间与温度,测定其敏感性和特异性。结果显示,RPA-LFD方法在37℃、15 min条件下,最低检测限为1 pg/μL,比普通PCR灵敏1000倍。同时,该方法与猫杯状病毒、猫疱疹病毒、犬冠状病毒、犬细小病毒、犬瘟热病毒均无交叉反应。通过9份临床病例的猫腹水样品检测,结果显示RPA-LFD与普通PCR结果一致。表明该方法快捷简便、特异性和灵敏性好,适用于快速检测FCoV感染。

摘要：Based on the lead compound 1 reported in literature, a series of novel BACE1 inhibitors were designed and synthesized, among which compound 11 exhibited a 14-fold improvement in potency over the lead compound 1. This represents a good lead for the discovery of more promising BACE1 inhibitors for the potential treatment of AD.

摘要：By taking compound 1 as a lead, a series of 5-cyclopropyl substituted cyclic acylguanidine compounds were designed and synthesized as BACE1 inhibitors, compound 4d exhibited 84-fold improved inhibition efficiency than lead compound 1. The diphenyl fragment at the P3 position and the substituents at the second phenyl ring were essential for the compounds to achieve improved inhibition efficiency. This SAR studies provides new insights into the design and synthesis of more promising BACE1 inhibitors for the potential treatment of AD.

摘要：Based on the lead compounds 1 and 2, a series of novel BACE1 inhibitors were designed and synthesized,among which compound 9h exhibited a 60 fold improvement in potency over the lead compound 1. This represents a good lead for the discovery of more promising BACE1 inhibitors for the potential treatment of AD. The result also showed that the prop-2-yn-1-yloxy is a suitable fragment for modification of cyclic acylguanidine BACE1 inhibitors.

摘要：Inhibition of VEGFR-2 signaling pathway has already become one of the most promising approaches for the treatment of *** this study,we describe the design,synthesis,and biological evaluation of a series of O-linked indoles as potent inhibitors of *** these compounds,18 showed significant anti-angiogenesis activities via VEGFR-2 in enzymatic proliferation assays,with IC50 value of3.8 nmol/L Kinase selectivity profiling revealed that 18 was a multitargeted inhibitor,and it also exhibited good potency against VEGFR-1,PDCFR-α and β.

摘要：Inhibition of VEGFR-2 signaling pathway is one of the most promising approaches for the treatment of cancer. In this paper, we reported the design, synthesis, and biological evaluation of a series of biphenylurea derivatives as VEGFR-2 inhibitors. Among these compounds, 39 exhibited potent inhibitory activity against VEGFR-2 both in vitro and in vivo. The antiangiogenesis activity of 39 was further confirmed by both tube formation assay and chick chorioallantoic membrane assay.

摘要：针对复杂产品的设计需求,深入分析了复杂产品的建模过程.基于参数化建模和多学科优化思想,建立了复杂产品综合优化设计的理论框架.其中,设计结构树存储了复杂产品从整机直到零件级结构信息;基于数据库协调的多学科协同寻优策略可以得到复杂产品的综合优化解.阐述了基于面向对象技术开发的数据库功能体系,该体系既保证了设计结构树中有效数据的存储,也为多学科协同寻优定义了相关操作.在实践应用上,开发了水轮发电机综合优化设计软件平台,应用实例验证了理论和实际研究工作的有效性和可行性.

摘要：This paper presents a neutronics design of a 10 MW ordered-pebble-bed fluoride-salt-cooled high-temperature experimental reactor. Through delicate layout, a core with ordered arranged pebble bed can be formed,which can keep core stability and meet the space requirements for thermal hydraulics and neutronics ***, objectives of the core include inherent safety and sufficient excess reactivity providing 120 effective full power days for experiments. Considering the requirements above, the reactive control system is designed to consist of 16 control rods distributed in the graphite reflector. Combining the large control rods worth about 18000–20000 pcm, molten salt drain supplementary means(-6980 to -3651 pcm) and negative temperature coefficient(-6.32 to -3.80 pcm/K) feedback of the whole core, the reactor can realize sufficient shutdown margin and safety under steady state. Besides, some main physical properties, such as reactivity control, neutron spectrum and flux, power density distribution, and reactivity coefficient,have been calculated and analyzed in this study. In addition, some special problems in molten salt coolant are also considered, including ~6Li depletion and tritium production.