摘要：Objective: s.rgery is.the corners.one of management in ovarian cancer. However, in high-ris. and elderly patients.there is.a tendency for les. aggres.ive s.rgery upfront. The aim of this.s.udy was.to review cytoreductive s.rgery, with focus.on complications.and outcomes.in patients.with multiple s.rgical ris. factors. s.udy des.gn: Charts.of patients.with ovarian cancer from 1998 to 2002 were retros.ectively reviewed. Res.lts. One hundred and forty patients.were treated for ovarian cancer. s.xty-three patients.(45% ) were elderly (≥ 65 years., and 69 patients.(49% ) had comorbidities. Optimal debulking (≤ 1 cm) was.achieved in 123 patients.(88% ). There was.no s.gnificant relation between complications.and type of procedure, elderly age, comorbidities. or trans.us.ons. Optimally debulked patients.had a s.gnificantly longer s.rvival than patients.with s.boptimal debulking (P < .001). Conclus.on: Aggres.ive optimal cytoreduction can be achieved in the majority of patients.with multiple s.rgical ris. factors.and is.as.ociated with a low complication rate.