摘要：A series of sulfenimine cephalosporin sulfoxide derivatives （Ta-v） were designed, synthesized and evaluated for their inhibitory activity against TEM-1 and cephalosporinase in cell-free systems. Some of the tested compounds showed enhanced inhibitory activity against class C β-lactamase cephalospor- inase compared with the tazobactam. The most promising compounds 7c and 7n （IC50 ~ 7.6 and 8.6 μmol/L, respectively） were further investigated in combination with cefradine against a variety of clinical isolated fi-lactamase-producing bacterial strains.

摘要：A comprehensive understanding of excited-state dynamics of semiconductor quantum dots or nanomaterials at the atomic or molecular level is of scientific *** inorganic(or non-covalently protected)seimiconductor molecular nanoclusters with atomically precise structure are contributive to establish accurate correlation of excited-state dynamics with their composition/structure,however,the related studies are almost blank because of unresolved solvent dispersion ***,we designedly created the largest discrete chalcogenide seimiconductor molecular nanoclusters(denoted P2-CuMSnS,M=In or/and Ga)with great dispersibility,and revealed an interesting intracluster“core–shell”charge transfer relaxation dynamics.A systematic red shift in absorption spectra with the gradual substitution of In by Ga was experimentally and computationally investigated,and femtosecond transient absorption measurements further manifested there were three ultrafast processes in excited-state dynamics of P2 nanoclusters with the corresponding amplitudes directed by composition *** results hold the great promise of the solution-processible applications of semiconductor-NC-based quantum dots and facilitate the development of atomically precise nano-chemistry.

摘要：The estrogen receptor is a target for therapeutic agents for hormone replacement in menopausal women,osteoporosis, reproductive cancers such as breast cancer,uterine cancer and prostate cancer.1,4-Dihydrothieno[3＇,2＇：5,6]thiopyrano[4,3- c]pyrazole-3-carboxylic amide derivatives were designed,synthesized and biological evaluated as potential estrogen receptor antagonists.

摘要：We synthesized a series of epoxysuccinic acid derivatives and evaluated their in vitro cathepsin K inhibitory activity The screening results show that the potency of compounds 9e,9d,9p,9j and 9k （IC_（50）≤0.005μmol/L） were equal to or greater than that of the lead compound *** hydrophobic compounds showed weaker potency,which can be explained by the hydrophobic nature of the cathepsin K binding pockets.

摘要：通过对节流理论的回顾 ,提出只需要制作盘管压力最大为 5 0MPa的水套炉 。

摘要：为了探索常用的阻燃剂对温拌阻燃沥青混合料阻燃性能的影响,采用IFR、EG和Sb_(2)O_(3)三种不同阻燃剂制备了温拌阻燃改性沥青,开展了氧指数试验和直接燃烧试验后沥青质量损失率试验,并对直接燃烧后温拌阻燃沥青混合料的路用性能损失率进行测试。结果表明,IFR、EG和Sb_(2)O_(3)三种不同阻燃剂均能够发挥一定的阻燃作用;在掺量相同的前提下,EG阻燃剂的阻燃效果最佳,其次是IFR阻燃剂,最后是Sb_(2)O_(3)阻燃剂。

摘要：CO2 is not only the most important greenhouse gas but also an important resource of elemental carbon and *** the perspective of resource and energy strategy,the conversion of CO2 to chemicals driven by renewable energy is of significance,since it can not only reduce carbon emission by the utilization of CO2 as feedstock but also store low-grade renewable energy as high energy density chemical *** studies on photoelectrocatalytic reduction of CO2 using renewable energy are increasing,artificial bioconversion of CO2 as an important novel pathway to synthesize chemicals has attracted more and more *** simulating the natural photosynthesis process of plants and microorganisms,the artificial bioconversion of CO2 can efficiently synthesize chemicals via a designed and constructed artificial photosynthesis *** review focuses on the recent advancements in artificial bioreduction of CO2,including the key techniques,and artificial biosynthesis of compounds with different carbon *** the basis of the aforementioned discussions,we present the prospects for further development of artificial bioconversion of CO2 to chemicals.

摘要：目的:针对目前广泛使用的基因分析仪存在更换耗材过程烦琐、电泳凝胶存储时间短的问题,设计一种八通道基因分析仪。方法:八通道基因分析仪机械结构由自动上样台、注胶模块、高压温控模块、光学模块和集成式U盒组成,电气控制系统由1台上位机(嵌入式计算机)和3个下位机(上样控制板、注胶控制板、高压温控板)组成。自动上样台包含x、y、z方向和光学对准共4轴电动机及传动系统,其中,传动系统主要采用皮带传动,光学对准电动机的螺纹采用消隙结构;注胶模块由注胶控制板控制,胶块为高透明亚克力材料;高压温控模块通过对低纹波精密高压电源的控制实现电泳电压的调节和电泳电流的检测,并采用比例-积分-微分(proportion-integral-differential,PID)算法控制加热炉的温度;光学模块由激发模块和收光模块组成,并采用低膨胀系数合金材料制作反射镜底座;集成式U盒将电泳凝胶、毛细管阵列、胶块、阳极缓冲液集成在塑料壳体中;上位机数据采集软件采用C#和C++编写,下位机均采用STM32单片机控制。结果:经测试,八通道基因分析仪的分辨力、精密度、准确度以及临床检测结果和目前广泛使用的ABI3500基因分析仪无明显差别。结论:八通道基因分析仪更换耗材简单、电泳凝胶存储时间长,能够满足基因测序的使用要求。

摘要：科学技术的每一次革新与发展都会给艺术创作的方式带来更大的启示,也可以这样说,科技图像影视技术的介入进一步拓展了绘画艺术的表现维度。直面当下由科技发展而带来的信息化时代,视觉图像的内容和形式变得愈加丰富,绘画技术和创作方式也因此得到了更大的发展空间,图像化创作方式也成为中国当代绘画创作的重要表现手段之一。

摘要：在解决鳍舵优化设计问题的过程中,引入集成优化框架iSIGHT,利用iSIGHT的优化迭代计算功能得到一种基于iSIGHT的鱼雷鳍舵优化设计方法,并将得到的设计方案与相同初值条件下通过传统方法得到的设计方案进行了分析和比较。分析比较的结果证明:用基于iSIGHT的优化设计方法来解决鱼雷鳍舵设计优化问题是可行的,并且能得到令人满意的设计方案。