摘要：Objective: To in.estigate the effects of hormon. therapy, estrogen.therapy an. tibolon. on.markers of apoptosis in.ludin. bcl-2, an. bax an. cyclin.D 1 expression.in.postmen.pausal vagin.l epithelium. Study design. Thirty postmen.pausal women.were ran.omized to the treatmen. protocols (0.625 mg con.ugated equin. estrogen.(CEE) ? 2.5 mg medroxyprogesteron. acetate (MPA); 2 mg estradiol valerate; 2.5 mg tibolon.). After baselin. vagin.l biopsy, con.rol biopsies were performed after 70 days followin. the in.tiation.of the therapy. Bcl-2, bax, Bcl-2/bax ratio, cyclin.D1 measuremen.s were performed immun.histochemically. Data were an.lyzed by Kruskal-Wallis, Man.-Whitn.y U an. Wilcoxon.tests. Results: After the treatmen. period the above-men.ion.d parameters were n.t differen. amon. the groups except for cyclin.D1 levels. Cyclin.D1 expression.was foun. to be stron. in.patien.s with treated estradiol valerate. Con.lusion.: The effects of estrogen.on.cyclin.D1 expression.were n.t detected with tibolon. or with the addition.of progesteron. to estrogen.in.the vagin.l epithelium. Cyclin.D1 appeared to have stron.er effects on.the estrogen.related proliferation.compared to apoptotic markers in.vagin.l epithelial cells.