摘要：This paper shows that one-dimensional(1-D) [and three-dimensional(3-D) computational fluid dynamics(CFD)] simulations can replace the state-of-the-art usage of pseudo-homogeneous dispersion or back mixing *** is based on standardized lab-scale cell experiments for the determination of droplet rise,breakage,coalescence and mass transfer parameters in addition to a limited number of additional mini-plant experiments with original ***,the hydrodynamic parameters can also be derived using more sophisticated 3-D CFD *** 1-D modeling served as a basis to replace pilot-plant experiments in any column *** combination of 3-D CFD simulations with droplet population balance models(DPBM)increased the accuracy of the hydrodynamic simulations and gave information about the local droplet *** high computational costs can be reduced by open source CFD codes when using a flexible mesh *** combined simulations using a three way coupled CFD/DPBM/mass-transfer solver pave the way for a safer design of industrial-sized columns,where no correlations are available.