摘要：a.unique porcine extra.ellula. ma.rix (ECM) derived injecta.le tissue construct with 100 nm or 20 nm gold na.opa.ticles (a.NP) wa. developed for musculoskeleta. tissue engineering a.plica.ions. ECM ha. been shown to encoura.e cellula.ity a.d tissue remodeling due to its relea.e of growth fa.tors while a.NP ha.e been shown to reduce rea.tive oxygen species (ROS) levels. Injecta.le tissue constructs were crea.ed by homogenizing decellula.ized porcine dia.hra.m tendon conjuga.ed with 100 nm or 20 nm a.NP a. 1x, 4x, a.d 8x concentra.ions. Extrusion force testing demonstra.ed tha. homogenized tissue constructs were injecta.le a. a. a.propria.e ca.nula.size a.d force. L-929 murine fibrobla.ts were used to mea.ure cell via.ility, cell prolifera.ion, intra.ellula. ROS levels, a.d cell migra.ion in response to constructs. Enha.ced cell via.ility a.d prolifera.ion a.e observed on 1 × 20 nm a.NP constructs. ROS a.sa.s demonstra.e reduced cellula. ROS concentra.ions from a.l 20 nm a.NP constructs a.d from 8 × 100 nm a.NP constructs compa.ed with constructs without na.opa.ticles. Cellula. migra.ion is higher towa.ds 4 × 20 nm a.NP constructs compa.ed with constructs without na.opa.ticles. Results support the potentia. use of a.porcine ECM derived injecta.le tissue construct with a.NP a. a. injecta.le tissue construct to reduce infla.ma.ion a.d to promote tissue remodeling in musculoskeleta. tissue engineering a.plica.ions.