摘要：Dermal substitutes have provided a template for the regeneration and reconstruction of the ***,the healed skin tissue often exhibits abnormal morphology and functionality,including scarring and *** this study,a composite bioink composed of methacrylated gelatin(GelMA)and chitosan oligosaccharide(COS)was proposed for printing a dermal scaffold using digital light processing(DLP)*** GelMA/COS bioink exhibited suitable porosity,swelling,degradation rate,and mechanical *** inclusion of COS demonstrated antibacterial effects against both Gram positive and Gram-negative bacteria,while simultaneously fostering the proliferation of human dermal fibroblasts(HDFs).Additionally,the application of COS could effectively reduce the expression levels of fibrosis-related genes,such as collagen I,collagen III,and fibronectin *** three-dimensionally printed cell-laden dermal scaffold exhibited excellent shape fidelity and high cellular viability,facilitating the extension of HDFs along the scaffold and the simultaneous secretion of extracellular matrix ***,the HDF-laden dermal scaffold transplanted into full-thickness skin defect sites in nude mice was shown to accelerate wound closure,reduce inflammation,and improve wound ***,the DLP-printed dermal scaffold provides an appealing approach for effectively treating full-thickness skin defects in clinical settings.

摘要：Traditional tumor models do not tend to accurately simulate tumor growth in vitro or enable personalized treatment and are particularly unable to discover more beneficial targeted *** address this,this study describes the use of threedimensional(3D)bioprinting technology to construct a 3D model with human hepatocarcinoma SMMC-7721 cells(3DP-7721)by combining gelatin methacrylate(GelMA)and poly(ethylene oxide)(PEO)as two immiscible aqueous phases to form a bioink and innovatively applying fluorescent carbon quantum dots for long-term tracking of *** GelMA(10%,mass fraction)and PEO(1.6%,mass fraction)hydrogel with 3:1 volume ratio offered distinct pore-forming characteristics,satisfactorymechanical properties,and biocompatibility for the creation of the 3DP-7721 *** analysis and quantitative real-time fluorescence polymerase chain reaction(PCR)were used to evaluate the biological properties of the *** with the two-dimensional culture cell model(2D-7721)and the 3D mixed culture cell model(3DM-7721),3DP-7721 significantly improved the proliferation of cells and expression of tumor-related proteins and ***,we evaluated the differences between the three culture models and the effectiveness of antitumor drugs in the three models and discovered that the efficacy of antitumor drugs varied because of significant differences in resistance proteins and genes between the three *** addition,the comparison of tumor formation in the three models found that the cells cultured by the 3DP-7721 model had strong tumorigenicity in nude *** evaluation of the levels of biochemical indicators related to the formation of solid tumors showed that the 3DP-7721 model group exhibited pathological characteristics of malignant tumors,the generated solid tumors were similar to actual tumors,and the deterioration was *** research therefore acts as a foundation for the application of 3DP-7721 models in drug devel

摘要：【目的】研究了氮化镓(GaN)和聚苯胺(PANI)复合材料在室温下对氨气(NH_(3))的气敏特性。【方法】以氧化镓(Ga_(2)O_(3))为镓源,采用原位氮化法制备了GaN微米结构,将GaN和苯胺单体预复合后,通过原位聚合法制备了GaN/PANI气敏传感器并对样品进行了一系列表征。【结果】结果表明GaN与PANI成功复合,GaN微米结构表面与网状PANI结合,从而为气体吸附提供了更多表面位点。测试并对比纯GaN和GaN/PANI复合材料的气敏特性,在室温低湿度条件下,GaN/PANI气敏传感器对体积分数100×10^(-6)的NH_(3)响应度可达80.73%,是相同体积分数的NH_(3)下纯GaN的1.7倍;另外,纯GaN的检测下限为1×10^(-6),而GaN/PANI复合气敏传感器的检测下限可达到1×10^(-9)。进一步分析GaN/PANI气敏传感器的传感机理,丰富的复合材料界面显著提升GaN/PANI传感器的气敏性能。GaN/PANI气敏传感器设计为室温下检测NH_(3)提供可靠方案。

摘要：微机电系统(MEMS)动态应力的瞬态特性决定了传统的应力测试系统无法直接满足它的测试需要。介绍了一种依据高频调制原理设计实现的基于拉曼光谱仪的MEMS动态应力测试系统,该测试系统是一个典型的光—机—电集成的MEMS测试系统。利用此测试系统对硅微谐振器支撑梁根部的单点进行了动态应力测试,测试结果与理论分析相吻合。实验表明,此测试系统具有高精度、非接触式、无损伤等特点,能很好地满足MEMS动态应力测试的需求。

摘要：3D打印技术已经在生物医学、传感器制造等领域得到广泛应用。然而,传统3D打印机由于自身工作方式的不同,适用范围不同,难以同时兼容生物制备和传感器制备。因此,以电磁阀作为3D打印机的喷头,自主设计并构建具有独特工作方式的3D打印机,将高精度液滴分配方式应用于3D结构打印。研究料筒气压、电磁阀开关时间、喷头高度对打印液滴直径的影响,并对点、线、网、面图案的打印质量进行评估;利用所构建的打印机制备具有真皮乳头结构的组织工程皮肤和阵列式柔性压力传感器,测试组织工程皮肤的细胞活性及压力传感器的压-阻转换特性。结果表明,打印液滴直径尺寸与料筒气压、喷头开启时间、喷头高度均成正相关;3D打印机对点、线、网、面图案的打印效果较为理想;可成功应用于具有真皮乳头结构的组织工程皮肤和柔性压力传感器的制备。所构建的3D打印机融合喷墨式打印机和挤出式打印机的优势,对打印墨水有较好的兼容性,具有打印方式简单、打印速度快、成型质量高的优点,对组织工程皮肤及柔性压力传感器的研究具有重要意义,为实现具有感知功能仿生皮肤的制备奠定基础。

摘要：针对传统振弦式传感器采集系统精度低,通道数少,实时性差的缺点设计了一种基于ARM和AD9833多通道数据采集系统。该系统将采集调理电路、数据存储、电源供电集成化,具备精度高,实时性强等特点。系统以ARM处理器为核心,结合改进的Rife和Quinn算法对经过FFT变换后的信号得到精确频率,并根据输出信号频率与待测量之间关系进行计算,系统将计算处理后的数据通过无线或有线传输方式将监测数据传输至监测后台,实现实时在线监控监测点的相关信息,上位机解析显示数据并存入数据库。分析实验数据可知,该采集系统与传统采集系统相比精确度更高,采集速度更快,能够提高振弦式传感器的实用性。

摘要：贵金属纳米颗粒的局域等离子体共振可以显著增强宽禁带半导体的可见光响应,但纳米颗粒小体积强散射特性存在吸收系数低的问题,严重限制了其光电转换效率。偶极子镜面效应通过相对简单的金属-介质-金属(metal-insulator-metal,MIM)结构就可以实现宽频谱高效吸收,而了解其性能随关键参数调变规律对于器件设计制备具有重要指导作用。以AuNPs/TiO_(2)/Au三明治结构为基础,通过时域有限差分法(finite difference time domain,FDTD)仿真了AuNPs/TiO_(2)/Au的电/磁场强度和面积,得到不同结构参数下电磁场以及吸收效率的变化趋势。仿真结果表明,中间介质层可以有效调控结构的光吸收特性。当介质层厚度为60 nm时,MIM三明治结构会产生最强的等离子磁共振,且在宽频带(500~850 nm)实现最佳的可见光吸收效率(92%).该研究为进一步设计基于MIM三明治结构的高效等离子光催化剂和光电器件提供了理论指导。

摘要：以Fowler理论模型为基础,通过将热电子注入过程分为热电子的产生、传输和发射3个部分进行量化分析,仿真计算了入射光子能量、贵金属纳米颗粒尺寸、以及肖特基势垒高度3个因素对热电子注入效率的影响。仿真结果表明,入射光子能量和热电子注入效率之间存在正相关关系、半径为5 nm左右的贵金属纳米颗粒具有最佳的热电子注入效率、热电子注入效率随着肖特基势垒高度的升高而逐渐降低。仿真结果加深了热电子注入物理过程的理解,为等离子光催化剂和光电器件的设计提供了理论指导。

摘要：设计了一种基于磁致伸缩共振的便携式液体黏度测量装置,可用于测量低黏度液体的黏度。在待测液体中,采集磁致伸缩振动片的共振频率,通过事先确定的共振频率和液体黏度计算公式,计算待测液体的黏度。该液体黏度测量装置主要由磁致伸缩振动片、磁铁、线圈、测量电路、按键和液晶屏组成。在测量电路中,单片机控制阻抗转换器测量线圈的阻抗变化,通过阻抗峰的顶点确定振动片的共振频率。通过测量磁致伸缩共振片在4种已知黏度的液体（异丙醇、甲醇、乙醇和丙酮）中的共振频率,确定共振频率和液体黏度的计算公式,该计算公式的测量范围为0.306-1.96MPa·s。对纯水进行测量,测量所得黏度为1.008MPa·s与已知纯水的黏度1MPa·s仅相差0.8%。

摘要：在总结传统微悬臂梁表面应力生物传感方法缺陷的基础上,提出了基于PDMS(polydimethylsiloxane,聚二甲基硅氧烷)微薄膜的电容式表面应力生物传感器,分析了其基本结构原理及优点,并运用ANSYS软件建立了传感器仿真模型,对相同表面应力下,Au电极大小不同的薄膜形变进行了仿真,计算输出电容。结果表明,薄膜形变量及电容改变量与Au电极在PDMS薄膜上的覆盖率有关,通过比较输出电容改变量与薄膜形变之间的关系,得出了传感器最优结构尺寸。