摘要：J-aggregates of cyanine have shown great merits in tumor photothermal therapy(PTT)due to their distinct redshift absorption as well as superior photothermal conversion efficiency(PCE).However,due to the complexity of intermolecular interactions,especially the impact of steric hindrance on aggregation,exploring effective strategies to regulate the aggregation modes of organic materials remains ***,steric hindrance-regulated J-aggregation of near-infrared(NIR)cyanine was reported based on Pt-coordinated cyanine self-assembly with unexpected“butterfly effect”.Two Pt-coordinated cyanine dimers CyR-Pt(R=Me and Et)were synthesized and spontaneously self-assembled into aggregates in aqueous ***-Pt aggregates were loose and amorphous *** replacing ethyl with methyl to reduce steric hindrance,a tiny change resulted in the generation of tightly stacked cyanine J-aggregates(thickness less than 3 nm)observed in CyMe-Pt ***,this unexpected“butterfly effect”enabled CyMe-Pt J-aggregates to effectively inhibit reactive oxygen species and greatly improve its ***,CyMe-Pt J-aggregates with NIR-II absorption exhibited outstanding photothermal stability and higher PCE(η=37%)than CyEt-Pt disordered aggregates(η=20%).Evident tumor suppression performance of CyMe-Pt J-aggregates was validated under 980 nm laser irradiation,demonstrating its great potential in tumor PTT.

摘要：采用MATLAB模块化编程将多目标粒子群优化算法MOPSO和反应谱分析联合起来进行抗震优化设计。根据桥墩在E1和E2两级设防水准地震作用下的抗震性能,采用Pushover分析墩顶的最大漂移率以及概率统计的方法得到全寿命期费用模型对应的工程费用,从而得到费用最小的Pareto解。数值计算结果表明:MOPSO算法和反应谱分析结合能够很好的应用于桥梁全寿命抗震性能设计分析,算法的收敛性和稳定性好,所求得的Pareto最优解在解空间分布均匀且范围较广,可以为桥梁设计提供良好的方案选择空间。