摘要：The secretion of melatonin(MT)is obviously different in the younger and the senior sectors of the population,and the maximum plasma concentration of seniors is only half of that in the younger population *** exogenous MT can be supplied to senior citizens based on the secretion rate and amount of endogenous MT in the younger population by a bio-mimetic drug delivery system(DDS),an improved therapeutic effect and reduced side effects can be *** upon this hypothesis,the pharmacokinetic parameters of MT,namely,the absorption rate constant(ka),the elimination rate constant(ke),and the ratio of absorption rate(F)to the apparent volume of distribution(V)were obtained by a residual method depending on the plasma concentration curve of immediate release preparations in the healthy younger *** dose-division method was applied to calculate the cumulative release profiles of MT achieved by oral administration of a controlled release drug delivery system(DDS)to generate plasma MT profiles similar to the physiological level-time *** in vivo release of MT deduced from the healthy younger population physiological MT profiles as the pharmacokinetic output of the bio-mimetic DDS showed a two-phase profile with two different zero order release rates,namely,4.919μg/h during 0-4 h(r=0.9992),and 11.097μg/h during 4-12 h(r=0.9886),*** the osmotic pump type of DDS generally exhibits a good correlation between in vivo and in vitro release behaviors,an osmotic pump controlled delivery system was designed in combination with dry coating technology targeting on the cumulative release characteristics to mimic the physiological MT profiles in the healthy younger *** high similarity between the experimental drug release profiles and the theoretical profiles(similarity factor f_(2)>50)and the high correlation between the predicted plasma concentration profiles and the theoretical plasma concentration profiles(r=0.9366,0.9163,0.9264)ind

摘要：目的验证葡萄糖注射液的灭菌工艺。方法通过对灭菌柜空载热分布实验、满载热分布实验和生物指示剂试验进行验证同时考察产品无菌状态以及主成分的变化。结果灭菌柜能够提供预定的灭菌条件,葡萄糖注射液经过灭菌操作后无菌检查合格,且其主成分改变很少。结论葡萄糖注射液通过灭菌验证。

摘要：针对药物分析学科的特点,结合学生的关注点及当前社会热点,围绕药物杂质检查教学,选取新型冠状病毒(COVID-19)肺炎的治疗药物磷酸氯喹,介绍其杂质检查方法及其在磷酸氯喹片质量控制中的重要作用,穿插现代药物史上一些著名的药害事件,融入疫情素材的课程思政建设进行教学设计。采用MOOC平台结合网络直播的混合式教学方式,结合实时评价,增加学生对药物分析研究内容的了解,敦促学生树立强烈的药品质量观念,养成严谨、细致、实事求是的工作态度。

摘要：目的提升学生的实际工作能力,培养学生的创新精神。方法药剂学的教学过程中,通过多元化教学模式如采用多媒体教学、案例式教学法、PBL教学法——启发式教学法、讨论式教学法等,并在教学中在系统介绍每种剂型基本知识后,引导学生进行一个与该剂型有关的实验设计等方式。结果提升了学生的综合能力,培养了学生创新精神,收到了良好的教学效果。结论多元化教学模式值得倡导、研究并推广。

摘要：通过多年从事全自动配料技术的开发、应用和生产,对国内外众多配料线的工艺和技术装备情况进行了总结,以达到完善原料车间装备技术,尤其是配料技术,提高和稳定配料精度,进而稳定玻璃质量。