摘要：The combined use of guided tissue/bone regeneration(GTR/GBR)membranes and bone filling grafts represents a classical therapy for guiding the regeneration and functional reconstruction of oral soft and hard ***,due to its displacement and poor mechanical support,bone meal is not suitable for implantation in the case of insufficient cortical bone support and large dimensional *** combination of GTR/GBR membrane with a three-dimensional(3D)porous scaffold may offer a resolution for the repair and functional reconstruction of large soft and hard tissue *** this study,a novel integrated gradient biodegradable porous scaffold was prepared by bonding a poly(lactic-co-glycolic acid)(PLGA)/fish collagen(FC)electrospun membrane(PFC)to a 3D-printed PLGA/nano-hydroxyapatite(HA)(PHA)*** consistency of the composition(PLGA)ensured strong interfacial bonding between the upper fibrous membrane and the lower 3D *** vitro cell experiments showed that the PFC membrane(upper layer)effectively prevented the unwanted migration of L929 *** in vivo investigations with an oral soft and hard tissue defect model in beagles revealed that the integrated scaffold effectively guided the regeneration of defective oral *** results suggest that the designed integrated scaffold has great potential for guiding the regeneration and reconstruction of large oral soft and hard tissues.

摘要：本着"就地取材、变废为宝"的原则,应用吹填海砂土进行路基填筑,经济效益较大,但是海砂土工程性能差,黏聚力小,地基土强度不易达到标准,需要使用无机结合料对其进行改良。通过土工试验测定吹填海砂土的基本性质,设计分别使用石灰和水泥改良吹填海砂土的试验方案,按照设计方案对改良后的海砂土进行界限含水率、无侧限抗压强度和三轴剪切试验。结果表明,采用石灰改良方案能有效提高抗剪强度,降低吹填海砂土的塑性,改善海砂土的工程性能。

摘要：目的系统分析机能学实验教学领域文献,展示21世纪以来我国机能学实验教学的发展脉络与研究方向。方法检索并筛选中国知网等数据库中有关机能学实验的文献(2000年1月1日至2021年12月31日),采用VOSviewer和CiteSpace可视化工具绘制知识图谱。结果共收集1801篇文献,2000年发文量27篇,2015年发文量119篇,2000至2005年平均发文44篇,2006至2016年平均发文101篇,2017至2021年平均发文86篇。关键词出现频次为:"机能实验室"108篇,"设计性实验"60篇,"实验教学改革"57篇,"综合性实验"50篇,"教学模式"47篇,共形成5个聚类。2021年的突现词为"翻转课堂""虚拟实验""教学方法及技术的应用","翻转课堂"突现强度最高。结论机能学实验教学领域发文量呈上升趋势,研究发展脉络为前期建设、全面建设、平稳发展和拓展细化4个阶段。研究可聚类为"实验室建设""实验教学改革""发展教学模式""三大学科实验课整合""创新能力",研究热点为"机能实验室""设计性实验""实验教学改革""综合性实验""教学模式"。研究前沿为发展教学模式,翻转课堂可能成为下一个研究热点。