摘要：In this study,a novel series of cordycepin derivatives with benzenesulfonamido groups at the 6-position of the purine ring were synthesized and their antitumor activity was *** revealed the structural moieties of the cordycepin analogs that were required for antitumor *** all the target compounds,those with 4-methyl and 4-nitro substituents on the benzene ring displayed better activity than the lead compound in antiproliferative activity experiments using MDA-MB-231 and A549 ***,compounds with 4-methoxybenzene and 2-oxoindoline groups and ethylene spacers displayed more significant activity than the lead compound in antiproliferative activity experiments using He La *** particular,a compound with a 4-bromo substituent and an ethylene spacer displayed very high inhibitory activity against the proliferation of MDA-MB-231,A549,and He La cells,suggesting that it had the potential for further development and application.

摘要：以豆腐果苷、取代苯乙酮和4-甲氧基苯肼为原料,设计合成了7个新型豆腐果苷-吡唑啉衍生物3a～3g,产物结构经1H NMR,IR和HRMS予以确认.初步生物活性测试结果表明,部分化合物具有一定的镇静催眠活性.

摘要：“飞行计划与空中交通流量管理系统”是新近研制成功并投入实际应用的一套计算机辅助管理软件，为民航航班的计划与协调过程提供帮助和咨询，协助计划员实现对航站和区域中航班流量的精确控制，并为违犯航管条例的非法航班提供专家咨询与建议，帮助计划员为其寻找合适的新时刻表。本文概括介绍了该软件系统的设计思想、主要功能和相关技术。