摘要：Alzheimer’s disease(AD)is a prominent form of dementia,characterized by aggregation of the amyloidβ-peptide(Aβ)plaques and neurofibrillary tangles,loss of synapses and neurons,and degeneration of cognitive ***,although a variety of medications can relieve some of the symptoms,there is no cure for *** breakthroughs in the stem cell field provide promising strategies for AD *** cells including embryonic stem cells(ESCs),neural stem cells(NSCs),mesenchymal stem cells(MSCs),and induced pluripotent stem cells(iPSCs)are potentials for AD ***,the limitation of cell sources,safety issues,and ethical issues restrict their applications in ***,the direct reprogramming of induced neural progenitor cells(iNPCs)has shed light on the treatment of *** this review,we will discuss the latest progress,challenges,and potential applications of direct reprogramming in AD treatment.