摘要：To expand the study on the structures and biological activities of the anthracyclines anticancer drugs and reduce their toxic side effects,the new anthraquinone derivatives,9‑pyridylanthrahydrazone(9‑PAH)and 9,10‑bispyridylanthrahydrazone(9,10‑PAH)were designed and *** 9‑PAH and 9,10‑PAH as promising anticancer ligands,their respective copper complexes,namely[Cu(L1)Cl_(2)]Cl(1)and{[Cu_(4)(μ_(2)‑Cl)_(3)Cl_(4)(9,10‑PAH)_(2)(DMSO)_(2)]Cl_(2)}_(n)(2),were subsequently synthesized,where the new ligand L1 is formed by coupling two 9‑PAH ligands in the coordination *** chemical and crystal structures of 1 and 2 were elucidated by IR,MS,elemental analysis,and single‑crystal X‑ray *** 1 forms a mononuclear structure.L1 coordinates with Cu through its three N atoms,together with two Cl atoms,to form a five‑coordinated square pyramidal *** 2 constitutes a polymeric structure,wherein each structural unit centrosymmetrically encompasses two five‑coordinated binuclear copper complexes(Cu1,Cu2)of 9,10‑PAH,with similar square pyramidal geometry.A chlorine atom(Cl_(2)),located at the symmetry center,bridges Cu1 and Cu1A to connect the two binuclear copper ***,the two five‑coordinated Cu2 atoms symmetrically bridge the adjacent structural units via one coordinated Cl atom,respectively,thus forming a 1D chain‑like polymeric *** vitro anticancer activity assessments revealed that 1 and 2 showed significant cytotoxicity even higher than ***,the IC_(50)values of 2 against HeLa‑229 and SK‑OV‑3 cancer cell lines were determined to be(5.92±0.32)μmol·L^(-1)and(6.48±0.39)μmol·L^(-1),respectively.2 could also block the proliferation of HeLa‑229 cells in S phase and significantly induce cell *** addition,fluorescence quenching competition experiments suggested that 2 might interact with DNA by an intercalative binding mode,offering insights into its underlying anticancer ***:

摘要：目的:研究终末期肾病患者对血液透析服务的选择偏好及影响因素。方法:基于标签式离散选择实验方法设计问卷,通过分层整群抽样方法开展调查,构建混合Logit模型,对408份有效样本进行服务偏好研究。结果:终末期肾病患者对社区血液透析服务具有显著的负向偏好;患者倾向于向上转诊通道流畅有效、医生固定、交通时间20分钟、提供家庭线下随访的血液透析服务,为此分别愿意多支付92.08元、74.52元、47.64元、17.63元;随着服务属性水平累积改变,患者选择社区血液透析服务的概率持续提升。结论:流畅有效的向上转诊通道是患者选择社区透析服务的关键;建议建设紧密型医联体,实现医疗同质化,保障患者安全;改善医患关系连续性,提高延续服务质量。

摘要：针对当前具有吞吐量和时延约束的软件无线电波形部署决策算法在内存开销方面考虑的不足,提出一个更为通用的波形部署决策系统模型,将波形的处理开销、内存开销和通信带宽开销都纳入到波形部署决策过程中,并设计了一种基于动态规划的波形部署决策算法以最小化波形对平台各种计算资源的占用总和。仿真结果表明,内存对波形部署决策具有重要影响,与未考虑内存开销的解决方案相比,平台支持的平均最大波形数目和平均处理资源利用率均下降40%左右。