摘要：Background:It is not completely clear whether a very high pre-therapy viral load(≥500000 copies/ml)can impair the virological *** aim of this study was to examine the influence of very high baseline HIV-RNA levels on long-term virological responses under one type of ***:A retrospective study was performed based on data from two multicenter cohorts in China from January to November 2009,and from May 2013 to December *** HIV infected adults between 18 and 65 years old were recruited before receiving non-nucleoside reverse transcriptase inhibitor-based *** patients had baseline HIV-RNA levels over 500 copies/ml,good adherence,and were followed for at least 24 *** suppression was defined as the first HIV-RNA<50 copies/*** failure was defined as any of incomplete viral suppression(HIV-RNA≥200 copies/ml without virological suppression within 24 weeks of treatment)and viral rebound(confirmed HIV-RNA level≥50 copies/ml after virological suppression).Chi-square test,Kaplan–Meier analysis,Cox proportional hazards model and Logistic regression were used to compare virological response between each pretreated viral load ***:A total of 758 treatment-naïve HIV patients in China were *** follow-up time(IQR)was 144(108–276)*** week 48,rates of virological suppression in three groups(<100000,100000–500000 and≥500000 copies/ml)were 94.1,85.0,and 63.8%,respectively(P<0.001).Very high baseline HIV viremia over 500000 copies/ml were found to be associated with delayed virological suppression(≥500000 vs<100000,adjusted relative hazard=0.455,95%CI:0.32–0.65;P<0.001)as well as incomplete viral suppression(≥500000 vs<100000,adjusted odds ratio[aOR]=6.084,95%CI:2.761–13.407;P<0.001)and viral rebound(≥50000 vs<100000,aOR=3.671,95%CI:1.009–13.355,P=0.048).Conclusions:Very high levels of pre-treatment HIV-RNA were related with delayed efficacy of NNRTI-based ART and increased risk of treatment failure.

摘要：Since cannon drum of agile shell-feeding system rotates frequently and intermittently, its motion must be steady. Outline of driving cam determines the motion of cannon drum, so it is necessary to select the proper outline of cam. Through analysis of parabolic outline and cycloid outline of the cams, the outline that combines the two curves is obtained. According to the demand of production,the value of the outline is revised, and then the method of fitting curve is used to get the expression of the angle of cam and the displacement of the driven part. Through analyzing the motion of the cannon drum, it is suggested that the angle of the cam is proportion to the displacement of the driven part. The cam with the specially derived outline can move steadily.

摘要：设计、合成了一种两亲性的引发转移终止剂(inifeter),2-(N,N-二羧甲基二硫代氨基甲酸酯基)异丁酸十二酯(DIBDC),通过核磁谱对其结构进行了表征.DIBDC既可引发聚合,又是表面活性剂.以DIBDC作为乳化剂,醋酸铜(Cu(OAc)_2)为催化剂,进行了细乳液聚合法制备聚合物空心球的研究.实验结果表明,通过细乳液聚合,制备了直径为100~200 nm的聚苯乙烯空心球.由于DIBDC中的二硫代氨基甲酸酯基团与卤素在化学行为上相似,因此,DIBDC可作为假卤素引发剂,在Cu(OAc)_2催化作用下产生自由基,从而引发聚合反应.Cu(OAc)_2存在于水相中,可以扩散到油水界面层与DIBDC作用,而活性自由基增长链始终处于油水界面,因此,聚合反应只能在油水界面层的"受限空间"内进行,从原理上避免了实心聚合物球的形成.

摘要：从资源整合的无障碍旅游区建设、引领市场发展的产品创新、人性化服务的创意宣讲、高科技支撑的文化创意4个方面,总结和借鉴我国红色旅游成熟区红色旅游产品开发的经验,分析左右江红色旅游区旅游产品开发现状,提出左右江红色旅游区革命历史名人文化、红色艺术文化、革命战争体验、革命生活体验、旅游商品五大红色旅游产品开发模式。

摘要：针对一类离散时间非线性系统,提出一种基于虚拟参考反馈整定的改进无模型自适应控制方案.首先,利用动态线性化方法给出非线性系统的紧格式动态线性化模型;然后,基于优化技术设计控制算法和伪偏导数估计算法;最后,设计基于虚拟参考反馈整定的伪偏导数初值和重置值的估计算法.该控制方案设计仅依赖于被控系统的输入和输出数据,且能保证闭环系统的稳定性和收敛性.仿真比较结果验证了所提出方法的有效性.

摘要：本文提出了一种基于恒定破裂速度和固定子事件震源时间函数的假定、利用远场地震波形资料获取大地,震震源机制的时空变化图像的线性反演方法,并利用这种方法及个球范围内48个台站的长周期波形资料反演建立了2008年汶川M_S8.0地震的震源机制随时间和空间变化的图像.根据这个图像可知,汶川大地震断层的西南端震源机制接近于逆冲,随着破裂向东北方向延伸,震源机制的走滑分量逐渐增大,走滑分量超过逆冲分量的转折点在震中东北大约190 km的位置.为了检验反演方法的有效性和反演结果的可靠性,我们特别设计了一个数值试验对反演结果进行了检验.检验结果表明,我们在本文中提出的反演方法是有效的,关于汶川大地震的反演结果也是可靠的(除长周期信号较弱的一段外).通过比较发现,反演结果与震后野外考察的结果也相当吻合.

摘要：为了使屏蔽暂堵钻(完)井液在井壁上形成渗透率接近零的泥饼,需要测量暂堵颗粒的粒度.介绍了光散射法粒度测量技术的原理、特点,并介绍了它在储层保护钻井液配方设计中的应用.与其他传统的粒度测量方法相比,它具有测量速度快、样品用量少、测量范围宽,无需用标准物进行标定等特点,是定量设计屏蔽暂堵钻(完)井液配方、优选暂堵颗粒的好方法,在石油行业及其它领域有着广阔的应用前景.利用该技术成功地为塔里木、青海、长庆等油田设计屏蔽暂堵型钻(完)井液配方.

摘要：研究一类离散T akag i-Sugeno(T-S)模糊时滞系统的稳定性分析和H∞控制器设计问题.通过构造适当的模糊Lyapunov函数,给出一种新型的基于线性矩阵不等式(LM I)的时滞相关稳定性充分条件,该条件比以往结果具有更小的保守性;在此基础上,提出了H∞模糊状态反馈控制器的设计方法.仿真结果表明了所提方法的有效性.

摘要：研究一类未知异构非线性多智能体的编队控制问题.首先,利用全格式动态线性化(full form dynamic linearization, FFDL)方法将未知非线性智能体转化为含有时变参数的数据模型,并给出时变参数的估计方法;然后,基于该数据模型设计一种分布式无模型自适应多智能体编队控制方案;最后,为验证所提出的无模型自适应编队控制方案的有效性,利用3台NAO机器人开发基于Python的多智能体编队控制实验平台.实验比较结果表明,通过所提出的控制方案可使3台机器人仅利用局部信息就能有效完成编队控制任务,控制性能优于基于PID的编队控制方法.

摘要：提出一种面向移动设备的3D图形处理器的设计方法,从图形算法和硬件架构两个层次进行优化.对图形算法进行C语言的仿真模拟,并设计高效的具有并行和流水线结构的图形处理器架构.该架构采用定点的数据通道,拥有一个可编程的顶点处理器和基于像素块的光栅扫描转换模块,降低电路复杂度的同时提高了整体性能.该设计已经在FPGA上验证,并给出了实验结果.实验结果显示该图形处理器结构可以满足移动设备的图形应用要求,具有可行性.