摘要：Novel histone deacetylase （HDAC） inhibitors 9a-1 were designed and synthesized by coupling the carboxyl group of salicylic acid （SA） with N-hydroxycinnamamides through various alkylol amines, and their in vitro biological activities were evaluated. The N-hydroxycinnamamide/SA hybrids 9b-f and 9h showed good to moderate anti-tumor activities. Notably, compound 9e had a greater potency, comparable to vorinostat （SAHA）, in human colon carcinoma cells, which was probably, or at least partially, attributable to the positive effects of the chain length noted in allojlol amines. Furthermore, the HDAC inhibitory activities of 9e against Hela cell nuclear were also similar to that of vorinostat （SAHA）, while the tested compounds 9c-f did not exhibit any isoform selectivity in the inhibition of HDACs. In addition, compound 9e could selectively inhibit tumor cells, but not inhibit non-tumor cell proliferation in vitro. Our findings suggest that the N-hydroxycinnamamide/SA hybrids may hold significant promise as therapeutic a^ents for the intervention of human cancers.

摘要：当前监控告警系统大都是根据用户具体某一种应用需求而设计的,这限制了系统应用扩展性。针对这一问题,设计一种新的系统。系统中相应的传感器对监控区域的信息数据进行实时采集,然后发送给单片机进行处理。单片机首先根据收到的各传感器数据对当前环境状态进行判断并向告警装置发送相应工作指令,然后将接收到的数据打包发送给后台计算机的应用软件,实现监控区域各项数据的可视化以及告警状态的可视化。系统的特点是能够根据具体应用环境组合搭配启用系统传感器,因此应用范围得到极大扩展。

摘要：Tolerance design, including tolerance analysis and distribution, is an important part of the electronic system’s reli- ability design. The traditional design needs to construct mathematic model of material circuit, which involves large amount of workload and lacks of practicability. This paper discusses the basic theory of electronic system’s reliability tolerance design and presents a new design method based on EDA (Electronic Design Automatic) software. This method has been validated through the application research on reliability tolerance design of the DC hybrid contactor’s control circuit.

摘要：Design intelligence,namely,artificial intelligence to solve creative problems and produce creative ideas,has improved rapidly with the new generation artificial ***,existing methods are more skillful in learning from data and have limitations in creating original ideas different from the training *** offers a promising method to produce creative designs by combining human inspiration and machines' computational *** propose a crowdsourcing intelligent design method called ‘flexible crowdsourcing design'.Design ideas produced through crowdsourcing design can be unreliable and inconsistent because they rely solely on selection among participants' submissions of *** contrast,the flexible crowdsourcing design method employs a cultivation procedure that integrates the ideas from crowd participants and cultivates these ideas to improve design quality at the same *** introduce a series of studies to show how flexible crowdsourcing design can produce original design ideas ***,we will describe the typical procedure of flexible crowdsourcing design,the refined crowdsourcing tasks,the factors that affect the idea development process,the method for calculating idea development potential,and two applications of the flexible crowdsourcing design ***,it summarizes the design capabilities enabled by crowdsourcing intelligent *** method enhances the performance of crowdsourcing design and supports the development of design intelligence.

摘要：Images are widely used by companies to advertise their products and promote awareness of their *** automatic synthesis of advertising images is challenging because the advertising message must be clearly conveyed while complying with the style required for the product,brand,or target *** this study,we proposed a data-driven method to capture individual design attributes and the relationships between elements in advertising images with the aim of automatically synthesizing the input of elements into an advertising image according to a specified *** achieve this multi-format advertisement design,we created a dataset containing 13280 advertising images with rich annotations that encompassed the outlines and colors of the elements,in addition to the classes and goals of the *** our probabilistic models,users guided the style of synthesized advertisements via additional constraints(e.g.,context-based keywords).We applied our method to a variety of design tasks,and the results were evaluated in several perceptual studies,which showed that our method improved users’satisfaction by 7.1%compared to designs generated by nonprofessional students,and that more users preferred the coloring results of our designs to those generated by the color harmony model and Colormind.

摘要：研究目的:为超大跨度斜拉桥抗风设计与抖振控制提供参考。研究方法:基于ANSYS建立了苏通大桥三维有限元模型,并在MATLAB平台模拟了苏通大桥三维脉动风场。考虑主梁断面气动自激力,进行了苏通大桥抖振时域分析。根据苏通大桥动力特性和抖振时域分析结果,重点分析了多重调谐质量阻尼器(MTMD)用于抖振控制的参数敏感性。考虑MTMD的控制效果、建造费用、施工难度及鲁棒性等因素建立了关于MTMD设计参数的目标函数,并基于一阶优化算法进行目标函数最优解的非线性搜索,据此获得了MTMD在约束条件下的最优设计参数。重要结论:1.苏通大桥侧向抖振位移主要由第一阶侧弯振型控制,竖向抖振位移主要由第一阶竖弯振型控制;***的控制效果对设计参数的变化十分敏感,其中质量比和频带宽敏感性更强;***的最优设计参数可以通过一阶优化算法获得,并可通过零阶优化算法对优化结果进行验证;4.采用优化后的MTMD设计参数,苏通大桥的抖振响应可以得到明显抑制,且侧向抖振控制效果更加明显。

摘要：针对我国现行《建筑抗震设计规范》中加速度反应谱长周期段尚存在的不足之处进行了探讨。按《中国地震动参数区划图》关于场地分类和地震动特征周期T_g的定义,从1 146次震级大于5级的真实强震中筛选出7 274条地震记录并进行分组。基于随机振动理论,由地震动Fourier幅值谱、功率谱和设计反应谱的转换关系得到统计意义上的能量密度分布和加速度反应谱,研究了地震动在长周期段的能量密度分布和加速度反应谱衰减规律。通过回归分析,对不同场地条件给出了设计反应谱长周期段合理的下降形式和斜率取值(周期延长至10 s),为规范修订提供参考。

摘要：复杂工程系统通常涉及到多个相互耦合的学科,而且其中往往存在不确定性因素。本文采用凸模型描述不确定性变量,将序列优化和可靠性评价方法应用于多学科可靠性优化之中,提出了一种新的多学科系统可靠性设计方法。在该方法中,可靠性分析采用功能度量法,多学科优化方法采用多学科可行方法或者二级系统一体化合成优化方法。数值算例和工程算例说明,该方法求解效率较常规嵌套求解方法效率高,为复杂工程系统的可靠性设计提供了一种新型求解算法。

摘要：目的从剂量学角度比较非均整器(FFF)模式下早期非小细胞肺癌(NSCLC)立体定向放射治疗的不同放疗技术。方法选取15例NSCLC作为研究对象,分别设计FFF模式下适形拉弧(CAT)、三维适形技术(3D-CRT)及容积弧形动态旋转调强(VMAT)计划。比较3种计划95%、105%的处方剂量覆盖靶区体积百分数(V95%、V105%)、靶区均匀度(HI)、适形度(CI)、最大剂量(Dmax)和平均剂量(Dmean)、危及器官(OAR)剂量、机器跳数(MU)及治疗时间(TT)。结果 CAT和3D-CRT计划中的计划靶区(PTV)V95%、CI低于VMAT计划(P<0.05),而V105%、HI、Dmax、Dmean高于VMAT计划(P<0.05);在患侧肺V5、V20、V30、V40、Dmean方面,CAT和3D-CRT计划高于VMAT计划(P<0.05);在患侧肺V20、V30方面,3D-CRT计划高于CAT计划(P<0.05);在脊髓Dmax,3D-CRT计划低于CAT与VMAT计划(P<0.05);CAT、3D-CRT计划的MU低于VMAT计划(P<0.05)。在治疗时间上CAT低于3D-CRT,且两者均少于VMAT(P<0.05)。结论 FFF模式下3种计划均能满足临床要求,靶区CI、HI及患侧肺保护的VMAT计划优于CAT和3D-CRT计划,但在执行效率,CAT和3D-CRT更具有优势。

摘要：在复杂的实时软件系统中使用构件式设计方法已成为目前软件工程中的研究热点。如何有效地验证实时软件的设计是否满足给定的时间规约,是实时计算领域中的主要挑战之一。文中提出了一种有时间特性的高阶多型π演算(THOπ-calculus),通过对不同阶上进程中活动关联的持续时间和最晚结束时间加以约束,给出了THO-π演算的操作语义。作为对π演算模型等价性分析的重要工具,在THO-π演算语义下提出了一种新的弱时间互模拟关系,并针对弱时间互模拟关系的阶次性定义了多分辨时间约束。通过对某导航软件的设计表明,该方法对实时软件构件内部、构件间的复杂动态时间约束有很好的表达与化简作用。