摘要：The aim of this study was to prepare pulsatile release tablets which provide different drug delayed-release time and realize personalized administration according to the needs of *** deposition modeling(FDM)3D printing technology was introduced into the field of pharmaceutics in this study,and the feasibility to prepare core-shell pulsatile release tablets was explored by combing 3D printing technology with the traditional manufacturing *** core of the pulsatile tablets was a commercial tablet obtained from the traditional technology,and the drug-free shell was prepared by the FDM 3D printing *** kinds of tablet shells were designed using different ***,the morphology,size,weight,hardness,and in vitro drug release of the 3D printed famotidine pusatile tablets were characterized and *** results showed that the 3D printed tablets appeared intact without any *** parameters of outer shell affected the size,weight,hardness,and in vitro drug release of the *** tablets achieved a personalized delayed release time varying from 5 to 7 h in *** this way,a new method for preparing pulsatile release tablets and a new way for the personalized administration of pulsatile tablets were explored in this study.

摘要：地理故乡是作家文学想象的生命现场和精神家园的皈依之所。采取文学空间的视角,从地理故乡与创作主体之间的地缘性关系、地域文化与文学景观之间的想象性关系、文学寻根与精神家园之间的皈依关系三个层次,探讨路遥、陈忠实、贾平凹的地理故乡、文学故乡、精神家园三者之间的关联和升华。从地理故乡到精神家园呈现出作家对生命意义的终极追寻。抗争与悲悯互渗的底层关怀是路遥作品中最具个人化的表现;历史与道德互参的史诗化追求是陈忠实文学创作的艺术表述;审视与忧患共存的文士情怀是贾平凹民族化的审美探索。在返乡书写的过程里文学成为故乡记忆的修复与重建,通过艺术的形式构建了具有哲学意义的精神家园。

摘要：高校建筑是用能重要用户,主要存在电、热两种用能形式,充分利用高校建筑屋顶资源开发太阳能项目并合理配置储能,能够有效提升用能经济性。以提高经济性为目标,设计了一种包含光伏、太阳能集热器、热泵和蓄电装置的屋顶光伏光热系统,考虑设备的购置和运维费用,利用差分进化算法求解出光伏光热系统中设备的最优容量配置结果,实现用户侧的单位电量成本最低。最后,以我国西北地区某一高校宿舍楼为实际算例,得到了该光伏光热系统的最小单位电量成本以及最优目标下的配置方案,为绿色低碳型校园建设提供借鉴。

摘要：Complex engineered systems are often difficult to analyze and design due to the tangled interdependencies among their subsystems and components. Conventional design methods often need exact modeling or accurate structure decomposition, which limits their practical application. The rapid expansion of data makes utilizing data to guide and improve system design indispensable in practical engineering. In this paper, a data driven uncertainty evaluation approach is proposed to support the design of complex engineered systems. The core of the approach is a data-mining based uncertainty evaluation method that predicts the uncertainty level of a specific system design by means of analyzing association relations along different system attributes and synthesizing the information entropy of the covered attribute areas, and a quantitative measure of system uncertainty can be obtained accordingly. Monte Carlo simulation is introduced to get the uncertainty extrema, and the possible data distributions under different situations is discussed in detail The uncertainty values can be normalized using the simulation results and the values can be used to evaluate different system designs. A prototype system is established, and two case studies have been carded out. The case of an inverted pendulum system validates the effectiveness of the proposed method, and the case of an oil sump design shows the practicability when two or more design plans need to be compared. This research can be used to evaluate the uncertainty of complex engineered systems completely relying on data, and is ideally suited for plan selection and performance analysis in system design.

摘要：在基于高层体系结构(high level architecture,HLA)的协同仿真中,随着仿真对象数量的增加,联邦成员之间的交互也在增多。在这种情况下,通常的以太网通信往往不能满足仿真成员之间的通信需求。共享内存作为一种高效的进程间通信机制,已经被广泛应用于系统间的通信,然而分布式共享内存对于计算节点间的通信支持尚显不足。该文通过反射内存构建了分布式仿真系统的全局共享内存环境,开发了基于全局共享内存的协同仿真运行支撑环境TH_SHMRTI,设计了相应的RTI(runtime infrastructure)通信机制,能够支持异构操作系统、异构混合平台上联邦成员之间高效的通信。测试结果表明,该通信机制能有效提高RTI在异构平台下的通信性能。

摘要：现有的CANDU重水堆(简称"重水堆")以天然铀作为燃料,但重水堆由于其独特的堆芯设计,具有较好的燃料灵活性,还可以烧低浓铀、回收铀和钍等燃料。研究现有重水堆改烧钍燃料后对堆芯特性和运行安全的潜在影响。使用DRAGON程序建立了重水堆的无限栅元模型,研究比较了钍燃料和天然铀燃料的重要堆芯特性参数。结果表明,尽管2种燃料下的堆芯特性有所差异,但钍燃料利用实际上有助于提升重水堆的运行安全。

摘要：为实现远程水文缆道平台在线测控,通过将嵌入式WebSocket的服务器与Web应用服务器结合,设计了一种基于Web技术的水文缆道测控系统。该系统以Web应用服务器为主,以嵌入式WebSocket Server提供缆道控制服务,具有以下特点:①客户端在访问应用服务系统的同时,可实现对水文缆道设备的即时控制,减少了中间中继环节,提高了系统的即时性与稳定性;②可降低硬件设备与业务功能的耦合性,减少了硬件设备升级维护难题;③可解决传统C/S(Client/Server)系统客户端软件升级维护的难题;④可适用于需要对远程硬件设备进行远程实时控制的各平台或系统。

摘要：为了探明不同品系白芥种子萌发期对两种中性盐(NaCl、Na_(2)SO_(4))和两种碱性盐(NaHCO_(3)、Na_(2)CO_(3))胁迫的耐受性,本试验选用3个白芥品系(11白芥3-1、13白芥15-2、12白芥15-7)为研究对象,设计0~240 mmol/L NaCl、0~210 mmol/L Na_(2)SO_(4)、0~75 mmol/L NaHCO_(3)和0~40 mmol/L Na_(2)CO_(3)四种盐碱胁迫处理,以蒸馏水为对照,通过分析发芽势、发芽率、发芽指数、芽苗鲜重、胚根长、胚轴长、耐盐阈值等指标的差异和相关性,探究了白芥种子萌发对不同盐碱胁迫的耐受性。结果表明,(1)12白芥15-7品系对Na_(2)CO_(3)胁迫的耐受性最强,11白芥3-1品系对NaHCO_(3)、NaCl和Na_(2)SO_(4)胁迫的耐受性最强。(2)当Na^(+)浓度一定时,白芥对SO_(4)^(2-)的耐受性比对Cl^(-)的强;HCO_(3)^(-)和CO_(3)^(2-)对白芥发芽率的影响程度因品系不同而有差异,但在Na^(+)浓度一定时,白芥对HCO_(3)^(-)的耐受性比对CO_(3)^(2-)的强。(3)20 mmol/L Na_(2)CO_(3)、45 mmol/L NaHCO_(3)、90 mmol/L Na_(2)SO_(4)和150 mmol/L NaCl可分别用于筛选对4种盐具有不同耐性的白芥种质。(4)15 mmol/L NaHCO_(3)、30~60 mmol/L NaCl处理对白芥种子胚轴和胚根伸长有一定的促进作用。(5)白芥种子萌发各指标间呈显著或极显著正相关,但与4种盐浓度均呈极显著负相关,其中发芽指数与NaCl、Na_(2)SO_(4)、NaHCO_(3)浓度间相关性最大,胚轴长与Na_(2)CO_(3)浓度相关性最大。本研究结果可为筛选适应不同盐碱地类型的白芥新种质提供理论基础,并为不同类型盐碱地生物治理中植物材料的选择提供参考。

摘要：土料分散性是筑坝土性质量关键性指标之一,影响着大坝工程长久安全使用,关注其特性及其物化特点是指导工程设计合理选择处理方案的重要依据。通过对土料基本物性试验,结合采用双比重计试验、碎块试验、针孔试验等方法研究土料的分散特性,得出一般黄土料用不同试验方法其分散性具有多样性成果,需采用合理方法予以评判,旨在对分布广泛的黄土中代表王瑶水库筑坝土料进行分析评价,以便为今后工程中判定利用此区风积黄土有一定的现实意义。

摘要：分析了在网络化制造环境下共享CAD软件的意义,提出基于CORBA的CAD软件封装系统,为实现远程设计、远程分析、远程制造、远程浏览、远程产品数据管理奠定了基础,并且分析了系统在实现过程中的难点。