摘要：In this paper,we present a 3D printed tumor spheroidal model suitable for drug *** model is based on a hydroxyethyl cellulose/alginate/gelatin(HCSG)composite biomaterial that has three distinct properties:(1)the HCSG is similar to the commercial basement membrane extract in Ki67,MUC1,and PARP1 expressions of MCF-7 cells for embedding culture;(2)the HCSG is printable at room temperature;and(3)the HCSG can be large-scale manufactured at an ultralow *** printed a 3D MCF-7 spheroid model with HCSG and characterized it in terms of cell viability,spheroid size,key protein expression,and mitochondrial metabolic *** used the 3D MCF-7 spheroid model to evaluate the anti-breast cancer activity of 13 amino acid-based flavone phosphoramidates and found that the alanine structure induced a stronger drug resistance,whereas phenylalanine hardly caused drug resistance in the MCF-7 *** is the first time that 3D bioprinting technology has been used in a structure–activity relationship study.

摘要：课程思政建设是当代高等教育改革的重要内容,也是高校提升“三全育人”教学成效、培养合格人才的现实需要。口腔医学教育过程中,思政课程及课程思政建设也日益被重视。针对进入住培阶段的口腔医学生,住培单位专设思政课程的概率较低,这就要求住培医疗教学机构及带教老师将思政建设重视起来。文章总结了上海市口腔医院住培过程中精心设计的课程思政方案,发掘思政元素并加归纳,明晰此阶段课程思政建设的内涵及要点,以利更好地在口腔住院医师规范化培训过程中高质量完成思政建设工作。

摘要：针对椰青加工领域效率低、危险性高等问题,设计一种自动转盘式剥椰塑型机。该机器工作时通过支撑站和顶杆将椰青夹紧固定,利用电机带动支撑站高速自转和主电机带动转盘切换工位,利用安装在各个工位机架上的切刀对高速自转的椰青进行切割塑型,使椰青表皮在不同工位受到不同方向切刀的剥皮作用,从而达到"粮仓状"椰青塑型目的。使用Solidworks绘制剥椰塑型机的三维结构图并进行实体建模,将模型导入ANSYS Workbench中进行关键部件的工作过程受力分析,获得各关键部件工作中应力和变形的变化规律。分析结果表明,塑型切刀和顶杆在不同载荷下受到的应力和变形趋势相似,载荷越大,应力值和变形趋势相应越大,各工位切刀与顶杆等关键部件材料的选用合理,切刀与顶杆工作受力情况满足剥椰塑型性能要求,可为青椰自动高效剥皮塑型提供一种可行方案。