摘要：We previously demonstrated that polypod-like structured DNA, or polypodna, constructed with three or more oligodeoxynucleotides （ODNs）, is efficiently taken up by immune cells such as dendritic cells and macrophages, depending on its structural complexity. The ODNs comprising the polypodna should bend to form the polypod-like structure, and may do so by adopting either a bend- type conformation or a cross-type conformation. Here, we tried to elucidate the orientation and bending of ODNs in polypodnas using atomic force microscopy （AFM）. We designed two types of pentapodnas （i.e., a polypodna with five pods） using 60- to 88-base ODNs, which were then immobilized on DNA origami frames. AFM imaging showed that the ODNs in the pentapodna adopted bend-type conformations. Tetrapodna and hexapodna also adopted bend-type conformations when they were immobilized on frames under unconstrained conditions. These findings provide useful information toward the coherent design of, and the structure-activity relationships for, a variety of DNA nanostructures.

摘要：目的:考察基本心理需要团体干预对低生命意义感初中生的干预效果。方法:采用实验组与对照组前后测设计,纳入50名低生命意义感初中生,随机分入实验组(25名)和对照组(25名),分别进行基本心理需要团体干预和无领导自由讨论团体活动,共进行8次团体干预,持续4周。用基本心理需要满足量表(BPNS)和生命意义感量表(MLS)评价干预效果。结果:在前测和中测中BPNS与MLS得分都不存在显著的组间差异(BPNS前测:t=-0.19,P=0.848,Cohen’sd=-0.06;BPNS中测:t=-0.86,P=0.397,Cohen’sd=-0.25;MLS前测:t=-1.75,P=0.088,Cohen’sd=-0.52;MLS中测:t=0.95,P=0.346,Cohen’sd=0.28)。而在后测中,实验组的BPNS和MLS得分都显著高于对照组(BPNS:t=2.10,P=0.041,Cohen’sd=0.62;MLS:t=4.19,P<0.001,Cohen’sd=1.45)。结论:针对基本心理需要的团体干预可以有效改善低生命意义感初中生的心理需要满足程度和生命意义感。

摘要：ROBERTO CAPPUCCI的新家在佛罗伦萨,THE ROBERTO CAPUCCI保管的多达400件如雕刻般的服装,也从罗马的VIA GREGORIANA 56号搬到了佛罗伦萨COSTA SAN GIORGIO 4号来,这里在佛罗伦萨也是一片可以俯瞰城市全貌的高地,更有面积宽广、绿意盎然的庭院,鲜花四处盛开。人在其中散步,如沐晨晖。在避荫的树下欣赏斜斜的西下夕阳,这里堪称是景色绝佳之地。

摘要：All engineering students need to develop their important skills of leadership in project management. Many students have never been leaders in their social and school lives. A leading role is unimaginable to them and hence they cannot imagine how to achieve it. The purpose of this paper is to report a result of a new leadership education program which links a variety of simulated experiences with real actions of students in project based learning （PBL） to develop their leadership ability. The first step is for graduate students to gain knowledge in the leadership arena. Then, they utilize simulation to experience leadership actions many times. Simulation provides a safe environment in which they can try out many different approaches in taking leadership in various situations. In the next step, students as a team utilize PBL, so that the above simulated experiences can help them to actually take leadership. Students can apply trained leadership to actual projects. It is highly effective to apply conscious leadership to a project aimed at a specific goal in limited circumstances. This education repeats both of the steps above, raising leadership abilities in an upward spiral. In terms of students＇ evaluation of leadership education in project management, 360-degree assessments were carried out by teachers, senior, and junior students before and after the course, and authors compare their assessments thoroughly. As a result, authors are assured that students not only gained knowledge but also raised leadership abilities in their actions after this education. Six months after the time of leadership education employing simulated experiences and PBL, follow-up interviews were conducted on its effects. Authors recognized the cyclic period that students apply simulated experiences to PBL and that they seek different approaches in simulation for solving problems found in reality. This research concludes that this cycle of simulator and PBL can produce effective leadership act

摘要：一年两度的东京时装展,像一块巨大的石块,投在了东京这个喷涌的大喷泉中,断断续续搅起的飞沫和波澜,融入东京时装的湍湍急流中。包括开幕、闭幕式在内延续约一个月的展会,让人感觉有点冗长。除了高潮的几天,观看多数安排在晚上的每天两个品牌的时装秀,就像每天的课程那样不可或缺,真不可思议。随着展会临近尾声,东京时装展的前景,像显影般逐步清晰显现出来。"在意自己的穿着打扮,努力学习来陶冶自身的艺术修养"

摘要：科尔贝尔(COLBERT)一词,源自法国路易14时代一位大臣的名字,这是个热衷于向海外传送法兰西优秀艺术文化的大臣。由法国高级品牌店组织的 COMIT COLBERT,便是这样一个以推广生活艺术为宗旨的展事。法国是一个以奢华高级时装而知名世界的国家,其众多的时装品牌在全世界受到关注。

摘要：在这个奢靡的T型台上，那些初出茅庐的学生会怎样诠释他们心中的服装？

摘要：这个百花烂漫的季节，娓娓诉说着东京的流行。

摘要：目的了解乳腺癌放疗患者健康坚韧性水平现状,分析乳腺癌放疗患者健康坚韧性的影响因素,为临床构建心理社会照护措施提供理论依据。方法采用方便抽样法,选取大连医科大学附属第一医院2018年1—9月乳腺癌术后放疗患者126例,采用自行设计的一般资料调查表和健康坚韧性量表(HRHS)进行问卷调查,分析患者健康坚韧性水平现状及影响因素。结果乳腺癌放疗患者HRHS总得分为(127.61±20.19)分,处于中等偏低水平;不同年龄、最高学历、婚姻状况、生育情况、子女情况、家里是否有其他人患有此疾病、宗教信仰、家庭人均月收入、医疗保险形式的乳腺癌放疗患者健康坚韧性水平得分比较差异均有统计学意义(t值为-3.800~8.128,F值为8.906~274.271,均P<0.01)。多元线性逐步回归分析得出,乳腺癌放疗患者健康坚韧性的影响因素为年龄、家庭人均月收入、婚姻状况、最高学历、家里是否有其他人患有此疾病、宗教信仰6个变量,可解释因变量的程度为89.4%。结论乳腺癌放疗患者健康坚韧性处于中等偏低水平,且受年龄、家庭人均月收入、婚姻状况、最高学历、家里是否有其他人患有此疾病、宗教信仰等多方面的影响。

摘要：生活在每个时尚之都的人，在街头都有极具个性化的服装风格．拥有着各不相同的穿衣文化，在世界时尚流行之风的浸染下．他们会怎样出场呢？