摘要：A highly efficient,simple,and clean single-step sonosynthetic procedure has been sophisticated for assembling new series of mono-and bis-pyridine dicarbonitriles from ketones,HCl,and *** presented protocol is applicable for the preparation of a broad range of uniquely substituted pyridine dicarbonitriles and seems to be superior in comparison with other previously reported *** antiproliferative impact of the newly synthesized derivatives was screened towards three representative cancer cell lines(MCF-7,A549,and HCT116).Most of the evaluated derivatives showed a moderate to excellent anti-proliferative activity towards the selected cell *** these,compounds 4h,4k,10,12a,and 12b showed both potent anticancer activity(ICs058μM)on non-tumorigenic cells(MCF-10A and NCM460),suggesting their promising potential to be lead molecules for future antitumor drug *** structure-activity relationships have been also ***,quantum chemical studies based on Density Functional Theory(DFT)of the synthesized compounds were investigated and found to be consistent with the in vitro inhibitory activities.