摘要：Platinum-based anticancer drugs, including cisplatin and its analogues, have played important roles in the clinical treatment of solid tumors over the past 38 years. However, poor selectivity, high toxicity and intrinsic or acquired drug resistance profoundly limit their application, which encourages the development of novel transition metal-based anticancer agents with different mechanisms of action. To this end, transition metal complexes that can simultaneously act on more than one target, termed as single-molecule multi-targeting complexes, have attracted increasing attention because of their enhanced efficacy and diminished chance of drug resistance. In this review, we systematically discuss the recent progress in the development of platinum- and ruthenium-based anticancer agents, in particular the rational design of platinum and ruthenium complexes with multi-targeting features.

摘要：One judiciously designed strategy of utilizing an ultrathin but conductive Ga_(2)O_(3):Si nanolayer to prepare(AlGa)_(2)O_(3)crystalline film is *** from the existence of Ga_(2)O_(3):Si nanolayer,a high-quality(Al_(0.68)Ga_(0.32))_(2)O_(3)sesquioxide film with 68 at.%aluminum was epitaxially grown on sapphire substrates,which was characterized by high-resolution transmission electron microscopy,X-ray photoelectron spectroscopy and X-ray *** bandgap was broadened to 6.14 eV,and a vacuum ultraviolet(VUV)(AlGa)_(2)O_(3)/Ga_(2)O_(3):Si photodetector was subsequently *** detector exhibits a pretty high on-off ratio of about 10^(3),an open-circuit voltage of 1.0 V and a responsivity of 8.1 mA W^(-1) at 0 V bias *** performances imply that the proposed strategy is valuable for improving the quality and also adjusting the bandgap of(AlGa)_(2)O_(3)sesquioxides,which is expected to facilitate their application in VUV photodetection.

摘要：An accurate measurement of the refractive index is necessary for the optical design of both deep ultraviolet laser diodes and light-emitting diodes. Generally, the refractive indices along different crystallographic axes of anisotropic thin films are measured using variable angle spectroscopic ***, there are still some limitations concerning this method. Here we proposed a potential method to measure the band edge refractive index of wide bandgap semiconductor. An aperiodic oscillation emission phenomenon due to the Fabry-Perot effect was observed in the fluorescence spectrum of an AlN film with a thickness of 1500 nm. Based on the characteristics of the fluorescence spectrum and the definition of Fabry-Perot effect, we obtained the ordinary refractive index of the AlN thin film near the band edge directly. This refractive index measurement method is a supplement to the variable angle ellipsometry,and it is a more direct and effective method for transferred film and thinner samples to measure the fluorescence spectrum.

摘要：Lanthanide(Ln^(3+))-doped near infrared(NIR)-II luminescent nanoprobes have shown great promise in many technological fields,but are currently limited by the low absorption efficiency of Ln^(3+)due to the forbidden 4f→4f ***,we report a novel NIR-II luminescent nanoprobe based on efficient energy transfer from Ce^(3+)to Er^(3+)and Nd^(3+)in sub-10 nm SrS nanocrystals(NCs),which are excitable by using a commercial blue light-emitting diode(LED).Through sensitization by the allowed 4f→5d transition of Ce^(3+),the NCs exhibit strong NIR-II luminescence from Er^(3+)and Nd^(3+)with quantum yields of 2.9%and 2.3%,***,by utilizing the intense NIR-II luminescence of Er^(3+)from the thermally coupled Stark sublevels of ^(4)I_(13/2),we demonstrate the application of SrS:Ce^(3+)/Er^(3+)NCs as blue-LED-excitable NIR-II luminescent nanoprobes for ratiometric thermal *** findings reveal the unique advantages of SrS:Ln^(3+)NCs in NIR-II luminescence,which may open up a new avenue for exploring novel and versatile luminescent nanoprobes based on Ln^(3+)-doped sulphide NCs.

摘要：Polarized upconversion luminescence(UCL)of lanthanide-doped micro/nano-crystals has shown great promise in single-particle tracking and super-resolution ***,because of the spectral line broadening and multiple sites of lanthanide in upconversion particles(UCPs),the crystal-field(CF)polarization components of UCL are usually ***,we report the linearly polarized UCL in LiLuF_(4):Yb^(3+)/Er^(3+) single microcrystals with resolvable CF transition lines and a polarization degree up to *** CF levels and CF transition lines of Er^(3+),as well as their emission polarization anisotropy,are unraveled for the first time through low-temperature and high-resolution photoluminescence(PL)and UCL *** taking advantage of the well-resolved and highly-polarized CF transition lines of Er^(3+),we demonstrate the application of LiLuF_(4):Yb^(3+)/Er^(3+) single microcrystals as anisotropic UCL probes for orientation *** findings provide fundamental insights into the polarization anisotropy of UCL in lanthanide-doped single particles,thus laying a foundation for the future design of anisotropic luminescent probes towards versatile applications.

摘要：结合现行国家标准中关于低谷电加热制备生活热水的要求,从低碳、节能、经济的角度出发,优化现有低谷电加热制备生活热水系统提出了若干种适用于不同场景的低谷电耦合太阳能或空气源热泵制备生活热水的可行方式。

摘要：研究目的:路基沉降问题是引起铁路、公路等基础设施发生工程事故的主要原因。为提高软土地区路基土沉降预测水平,本文考虑土体的非达西渗流效应、土体边界透水能力的变化以及变形非线性特征,建立相应的分段线性化固结模型。其中,起始坡降渗透模型用来反映土体的非达西渗流过程,连续排水边界用来描述土体边界透水性能的变化,e-lg(av0)关系用来表示土体的非线性变形特征。然后,应用一些算例分析探讨边界透水性能变化、土体非线性变形以及非达西效应下土体的固结行为,以期为软土路基工程工后沉降预测提供理论支撑。研究结论:(1)土体的非达西效应越强(即起始坡降值越大),边界透水性能越差(即连续排水界面参数越小),相同时刻下的固结滞后现象越明显;(2)起始坡降值能同时影响固结过程及最终结果;(3)连续排水边界和起始坡降下初始压缩系数对沉降过程的影响比较显著;(4)本文固结模型可模拟深厚软土路基的沉降过程,相关结论可应用于深厚软土的堆载排水加固过程。

摘要：集成电路超纯水制备系统的精处理工艺段提供了微污染控制的保障环境。在痕量污染控制环境下,以铂族金属为代表,构建金属纳米粒子对氢氧合成反应的复相催化体系,可以实现多元微污染物的联合降除,进而满足3nm制程超纯水制备系统溶解气体和痕量氧化剂的控制要求。研究阐述和总结了氢氧合成反应的四种反应机制和催化作用机理,重点讨论了金属表面结构、活性位点、形貌尺寸、合金组分、载体性质、液相反应环境对各反应途径催化活性及选择性的密切影响,形成了洁净水相氢气氧化反应的边界条件,对于金属纳米粒子在超纯水领域的应用研究具有导向意义。

摘要：扩压式自泵送流体动压机械密封作为1种新的密封结构形式具有优异的密封性能和广泛的应用前景.分别设计出具有等截面型扩压环槽、发散型扩压环槽、收敛型扩压环槽和圆弧型扩压环槽4种扩压式自泵送流体动压机械密封,引入综合评价因子η,通过Fluent数值模拟分别对其综合密封性能进行了分析.基于最佳的扩压环槽结构,通过正交试验,对密封面结构参数进行优化.结果表明:等截面型扩压式自泵送流体动压机械密封综合密封性能最优;在试验参数范围内,螺旋槽数Ng和密封环外径rk对泄漏率均有影响,且螺旋槽数Ng影响最为显著.密封环外径rk和螺旋角α对开启力均有影响,其中密封环外径rk的影响更为显著,随密封环外径的增大,开启力迅速增大.依据正交试验分析结果,对密封面结构参数进行了优化,在其他边界条件均不变的情况下,新的因素水平组合得到的泄漏率最低为0.784361 ml/h,此时开启力大小为3.958962 kN.

摘要：以第74、78窟为代表的麦积山早期洞窟年代上限可以到十六国晚期,下限在北魏洛阳时代之前。这些早期洞窟与河西石窟连为一体,可统称为“大凉州石窟”,其来源近为新疆,远则中亚乃至印度。“大凉州石窟”并无鲜明统一特征,而以各地各具特色为主,其形成背景在于各地对东来佛教艺术的自由吸收和发挥,这与十六国时期的历史特性相符。与以往认识不同,本文认为麦积山早期洞窟影响了云冈石窟。包括麦积山早期洞窟在内的“大凉州石窟”曾影响到云冈,但不限于云冈,这个认识对于理解东部地区石窟具有重要的意义。