摘要：Background:Renal artery stenosis (RAS) is always associated with abnormalities in renal microvascular perfusion (RMP).However,few imaging methods can simultaneously evaluate the degree of luminal stenosis and ***,this study will aim to evaluate the feasibility of using contrast-enhanced ultrasound (CEUS) for assessing both RAS and RMP to achieve a one-stop assessment of patients with suspected renovascular hypertension. Methods:This will be a single-center diagnostic study with a sample size of *** with chronic kidney disease (CKD) and suspected of having resistant hypertension will be *** with Stages 1–3 CKD will undergo CEUS and computed tomography (CT) angiography (CTA).Values obtained by CEUS and CTA for diagnosing low-grade (lumen reduced by <60%) and high-grade (lumen reduced by ≥60%) RAS will be ***,all patients will also undergo radionuclide *** diagnostic value for RAS will be assessed by the receiver operating characteristic curve,including the accuracy,sensitivity,specificity,positive predictive values,negative predictive values,and area under the *** correlation analysis will be performed to assess the association between CEUS findings for RMP and glomerular filtration rate measured by a radionuclide imaging method. Conclusion:The data gathered from this study will be used to evaluate the feasibility of expanding clinical applications of CEUS for evaluation of patients with suspected renovascular hypertension.

摘要：提出一种基于改进人工势场法且带有输入量化的欠驱动无人船编队协同避碰避障策略.借鉴导弹制导与控制机理,分层设计无人船运动学制导律与动力学控制律.首先,基于辅助变量法在无人船运动学子系统中设计分布式制导律,并引入改进人工势场法的斥力函数.通过重构制导律实现运动学层面的协同避碰避障以及欠驱动无人船期望轨迹的跟踪;其次,通过使用径向基神经网络对无人船动力学子系统中的外界干扰和系统未建模动态进行逼近,采用均匀量化器对输入变量进行量化并对量化过程进行线性描述,使得底层量化控制器无需预测关于量化参数的具体信息;在稳定性分析中,利用李雅普诺夫稳定性理论证明所设计USV编队跟踪控制系统的稳定性;最后,采用matlab对理论策略进行仿真实验,仿真结果验证了所提出策略的有效性.

摘要：【目的】研究不同剂量连作障碍调控肥对土壤物理性质和玉米经济效益的影响。【方法】在连作13 a的制种玉米土壤上,采用田间试验方法,以制种玉米连作障碍调控肥施用量为梯度设计7个处理,分别为:CK,0.85、1.70、2.55、3.40、4.25和5.10 t/hm^2。以不施肥为对照,每个试验处理重复3次,随机区组排列。【结果】随着连作障碍调控肥施用量由0.85增加到5.10 t/hm^2时,与对照比较,土壤总孔隙度、团聚体、饱和持水量分别增加了6.42%、14.63%和17.91%,土壤容重降低了11.11%,差异极显著(P<0.01);制种玉米株高、茎粗、生长速度、地上部分鲜重和地上部分干重分别增加了26.06%、32.12%、26.05%、48.05%和48.06%,差异极显著(P<0.01);制种玉米穗粒数、穗粒重和百粒重分别增加52.24%、46.06%和20.70%,差异极显著(P<0.01);制种玉米产量增加了46.04%,差异极显著(P<0.01);但1 kg连作障碍调控肥的增产量则随着连作障碍调控肥施用量的增加而递减为63.64%。【结论】连作障碍调控肥施用量大于3.40 t/hm^2时,施肥利润出现了负值,连作障碍调控肥适宜用量一般为3.40 t/hm^2,此施用量下,制种玉米的理论产量为6.91 t/hm^2,经济效益最好。

摘要：Cyclic dinucleotides(CDNs) are known to activate stimulator of interferon genes(STING) and induce type I interferon responses, therefor possess great potentials to be of immunotherapeutic value for cancers and infectious diseases. However, the existence of different single nucleotide polymorphism(SNP) of human STING(hSTING) gene poses an obstacle to achieve broad-spectrum activation by CDNs. We reported here the design and synthesis of a total of 36 CDNs, representing all structural variations, that contain four bases(A, G, C, U) and two linkage directions(2′-5′-linked and 3′-5′-linked phosphodiester).Through systematic evaluation of IFN-β induction with a dual-luciferase reporter assay, we discovered that wild type hSTING and two isoforms(HAQ and AQ) showed strong response while hSTING-R232 H and R293 Q exhibited the relatively weak response to CDNs stimulation. For the first time, we found that the c[G(2′,5′)U(2′,5′)] showed excellent activity against all five hSTING variants even equivalent to the endogenous ligand c[G(2′,5′)A(3′,5′)]. Furthermore, we have also demonstrated that 3′-3′CDNs with two 3′-5′ phosphodiesters showed higher serum and hydrolase stability than 2′-2′ CDNs with two 2′-5′ phosphodiesters and 2′-3′ CDNs with one 2′-5′ and one 3′-5′ phosphodiester. It is very interesting to note that 2′-2′ CDNs has been found for the first time to show strong activity. These findings will stimulate our exploration for the new functional role of CDNs, and provide guidelines to design CDNs based hSTING targeted drugs.

摘要：滦平抽水蓄能电站装机容量1 200 MW,装设4台300 MW抽水蓄能机组,工程主要任务是承担京津唐电网调峰、填谷、储能、调频、调相、紧急事故备用等,并促进矿区生态修复。文章对该电站可行性研究阶段水泵水轮机主要参数的优化选择及关键技术研究进行了介绍。

摘要：In this paper, an approach for designing robust fault detection filter (RFDF) of networked control systems (NCSs) with unknown inputs is studied. The design aims at implementing the optimal trade-off between robustness of unknown inputs (including the item produced by networked-induced delay) and sensitivity of fault. The key design issue is to introduce an optimal fault detection filter based on NCSs with the control law compensation as the reference residual model of NCSs and to formulate the RFDF design as a model-matching problem. By applying H∞ optimization technique, linear matrix inequality (LMI) approach is given to solve the model-matching problem. The validity of the proposed approach is shown by a numerical example.

摘要：本文对导弹/火箭制导、导航与控制(GNC)技术的发展进行了综述。总结归纳了不同阶段GNC关键技术的突破与跨越,重点对惯性导航、组合导航、摄动制导、闭路制导、迭代制导、频域设计、全数字设计、冗余控制、自适应控制等多项技术进行了总结和应用成果论述。对未来GNC技术的发展进行了思考与展望,并提出了七项关键技术。针对更聪明、更自主的弹/箭控制技术发展需求,提出并分析了"会学习"弹/箭的制导、导航与控制技术。

摘要：Based on the elastic thin plate theory,the main law of the ore roof failure was analyzed and the formula of the ore roof thickness was *** results show that the tensile stress in the roof center accounts for the roof *** to the limit failure conditions of the point,the formula of the ore roof thickness was *** No.10 stope of a bauxite mine as an engineering case,the optimal thickness of the ore roof was 0.36 *** safety factor was taken as 1.3,therefore the design thickness was 0.5 *** the whole industrial test process,the dynamic alarm devices did not start the alarm and the ore roof was not *** with other stopes under similar conditions,its thickness was reduced by 0.1-0.3 *** recovery rate of the ore roof was increased by 16.7%-37.5%.

摘要：对于实际工程的管理者和决策者来说,工程整体费用和工期之间如何达到均衡以及工程所处环境的不确定性是两个必须要面对和考虑的问题.基于相关机会规划的思想,针对随机性和模糊性并存的复杂不确定环境,提出了一类时间费用均衡模型.在建立的模型中,以模糊随机变量来刻画工程所处的复杂不确定环境.随后,结合模糊随机模拟方法和遗传算法设计了一种混合智能算法,用于求解该模型.最后,通过数值实验来验证所设计算法的有效性和稳定性.

摘要：Developing materials with excellent properties has been the untiring pursuit of *** glasses(MGs)would be the ideal metallic materials if their size could be scaled up to be comparable to traditional *** address this challenge,a variety of approaches have been attempted over the past decades,including thermodynamicsbased alloy,3D printing and the recent artificial intelligenceguided optimal *** this study,a facile and flexible route was demonstrated to manufacture giant MGs(GMGs)with diameters more than 100 mm through the thermo-joining *** jointed GMG samples feature almost the same performance as the as-cast *** ability of manufacturing complex 3D components such as the Chinese Zodiacs was also *** approach might overcome the longstanding problem of glass forming ability(GFA)limitations in alloy systems and pave new concept and route to fabricate size unlimited MGs.