摘要：Background： A comprehensive metabolism network of engineered E. coli is very important in systems biology and metabolomics studies. Many tools focus on two-dimensional space to display pathways in metabolic network. However, the usage of three-dimensional visualization may help to understand better the intricate topology of metabolic and regulatory networks. Methods： We manually curated large amount of experimental data （including pathways, reactions and metabolites） from literature related with different types of engineered E. coli and then utilized a novel technology of three dimensional visualization to develop a comprehensive metabolic network named SynBioEcoll. Results： SynBioEoli contains 740 biosynthetic pathways, 3,889 metabolic reactions, 2,255 chemical compounds manually curated from about 11,000 metabolism publications related with different types of engineered E. coil Furthermore, SynBioEcoli integrates with various informatics techniques. Conclusions： SynBioEcoli could be regarded as a comprehensive knowledgebase of engineered E. coli and represents the next generation cellular metabolism network visualization technology. It could be accessed via web browsers （such as Google Chrome） supporting WebGL, at http：//***/synbioecoli/.

摘要：针对从理论上无法分析引信曲折槽机构曲折槽宽度、过渡圆角和深度对机构动态特性影响的问题,提出采用ADAMS动力学分析软件对曲折槽机构解除保险过程及结构参数进行仿真分析。结果表明:该引信曲折槽保险机构在80 g发射过载下能可靠解除被保险部件,在1.5m高度跌落钢板、水泥地和砂土目标能保证被保险部件安全性,与试验结果相符;在一定范围内增大惯性筒上曲折槽宽度、曲折槽拐角处圆角及曲折槽深度均有利于曲折槽保险机构解除保险,反之则有利于勤务处理安全性。