摘要：Non-volatile random-access memory（NVRAM） technology is maturing rapidly and its byte-persistence feature allows the design of new and efficient fault tolerance mechanisms. In this paper we propose the versionized process（Ver P）, a new process model based on NVRAM that is natively non-volatile and fault tolerant. We introduce an intermediate software layer that allows us to run a process directly on NVRAM and to put all the process states into NVRAM, and then propose a mechanism to versionize all the process data. Each piece of the process data is given a special version number, which increases with the modification of that piece of data. The version number can effectively help us trace the modification of any data and recover it to a consistent state after a system *** with traditional checkpoint methods, our work can achieve fine-grained fault tolerance at very little cost.

摘要：主要研究培养条件对动物双歧杆菌活菌数的影响,design-expert软件辅助优化设计,以期更好的为双歧杆菌的研究提供基础数据及满足工业化生产需要。采用改良的玉米糖化液为培养基,以活菌数为响应值,选取不同的玉米糖化液浓度、培养温度、接种量和初始p H,借助design-expert软件建立四因素三水平的试验,得到响应值与各因素之间交互作用的数学模型。结果表明:接种量与培养温度一次项显著,4个因素的二次项及玉米糖化液浓度与接种量的交互项显著,其他项不显著。动物双歧杆菌的最佳培养条件分别为:接种量7.4%,玉米糖化液浓度12.0°Bx,初始p H6.5,培养温度37.4℃。

摘要：磁浮飞行风洞是一种将真空管道高速磁浮技术与动模型试验原理相结合的新概念空气动力试验设施。试验模型在试验过程中由于受到气动载荷、惯性载荷和轨道不平顺的联合作用,会发生系统振动和姿态改变。利用动力学软件建立动模型系统的多体刚柔耦合动力学模型,通过仿真计算了系统模态演变及动力学响应情况。结果表明:动模型在起飞时刻会发生剧烈振动和姿态改变;当运行速度为0.4马赫数时,轨道不平顺激扰频率会与动模型系统固有频率耦合引起系统共振,导致悬浮高度发生较大幅度的谐波振荡,共振频率为7.4 Hz,振荡幅度为8.9 mm;动模型俯仰姿态角随试验马赫数的增大而增大,当试验马赫数为0.5时,试验模型最大俯仰角约为2.25°。研究结果对于磁浮飞行风洞相关系统的设计与发展动模型试验技术具有参考意义。

摘要：Cyclic dinucleotides(CDNs) are known to activate stimulator of interferon genes(STING) and induce type I interferon responses, therefor possess great potentials to be of immunotherapeutic value for cancers and infectious diseases. However, the existence of different single nucleotide polymorphism(SNP) of human STING(hSTING) gene poses an obstacle to achieve broad-spectrum activation by CDNs. We reported here the design and synthesis of a total of 36 CDNs, representing all structural variations, that contain four bases(A, G, C, U) and two linkage directions(2′-5′-linked and 3′-5′-linked phosphodiester).Through systematic evaluation of IFN-β induction with a dual-luciferase reporter assay, we discovered that wild type hSTING and two isoforms(HAQ and AQ) showed strong response while hSTING-R232 H and R293 Q exhibited the relatively weak response to CDNs stimulation. For the first time, we found that the c[G(2′,5′)U(2′,5′)] showed excellent activity against all five hSTING variants even equivalent to the endogenous ligand c[G(2′,5′)A(3′,5′)]. Furthermore, we have also demonstrated that 3′-3′CDNs with two 3′-5′ phosphodiesters showed higher serum and hydrolase stability than 2′-2′ CDNs with two 2′-5′ phosphodiesters and 2′-3′ CDNs with one 2′-5′ and one 3′-5′ phosphodiester. It is very interesting to note that 2′-2′ CDNs has been found for the first time to show strong activity. These findings will stimulate our exploration for the new functional role of CDNs, and provide guidelines to design CDNs based hSTING targeted drugs.

摘要：粤港澳大湾区是中国重要的经济中心,过去30年间经历了快速城镇化,对区域的植被、农田和水体等生态系统产生了重要的影响。揭示快速城镇化对水资源的影响对于水资源管理与规划、生态环境保护等具有重要意义。然而,现有研究对粤港澳大湾区水体的时空变化认识仍然不足,限制了水资源管理与规划、环境保护等政策的制定与实施。本研究旨在利用1990—2020年粤港澳大湾区的密集时间序列Landsat影像数据,使用深度学习模型WatNet提取水体,并对水体动态变化进行时空变化分析,从而探究快速城镇化背景下粤港澳大湾区城市群水体动态变化过程和结果。结果表明:1)粤港澳大湾区的水体面积呈“上升—小幅波动—下降”趋势,水体收缩的区域主要分布于珠江下游及珠江口沿岸地区,水体扩张的区域主要分布于粤港澳大湾区西南部;2)粤港澳大湾区全域水体面积与自然地理指标相关性弱,与经济社会指标的相关性明显,其中与人口、国内生产总值等经济社会指标具有显著的负相关关系;3)基于密集时间序列结果对水体转出地类进行分析,2020年与1990年相比,最终有40.17%的水域转化为不透水面,密集时间序列分析发现其转化过程大致为“水体→农田/湿地→不透水面”。本研究基于密集时间序列Landsat影像的研究结果,揭示了粤港澳大湾区近30年来水体动态变化的详细情况及其主要驱动因素,有助于了解大湾区水资源的时空演变,同时也为快速城镇化地区制定针对性的水资源管理策略、优化生态环境保护措施以及预测城市化对水体变化的潜在影响提供了科学依据和决策支持。

摘要：A new linac injector CSR-LINAC for the Cooler Storage Ring of the Heavy Ion Research Facility in Lanzhou(HIRFL-CSR) is proposed to improve the performance of the HIRFL. As a key component of the CSRLINAC, the 108.48-MHz radio frequency quadrupole(RFQ) is under design at the Institute of Modern *** ions with mass-to-charge ratios of 3–7 will be accelerated from 4 to 300 keV/u by the RFQ. In the beam dynamics design, the New Four-Section Procedure is adopted to improve the transmission efficiency and obtain a compact structure. In this paper, a transmission efficiency of 98.0% in the 3.07-m-long cavity was obtained. The Interdigital H-type structure is employed because of its mechanical stability and high shunt impedance. The RF performance of the cavity is investigated by the electromagnetic simulation. The optimized results of the electric field to meet the beam dynamics requirements are presented in this paper.

摘要：为了解决全电飞机电力系统对可靠性和安全性要求都较高的问题,本文提出了一种基于多级可靠性分析的全电飞机电力系统多目标优化设计方法。此方法首先将全电飞机中复杂的电力系统设计过程解耦为多级设计过程,每一级设计过程都在考虑成本、可靠性等指标的基础上建立一个非线性优化模型,然后利用层次分析法确定权重系数,将多目标优化问题转换为单目标优化问题,并将非线性模型线性化最终转化为01规划模型,通过求解该模型获得不同权重系数下对应的电力系统最优拓扑结构以及相应功率器件的额定功率。对不同权重系数下的设计结果分析得出:当可靠性指标权重较小时,全电飞机电力系统拓扑结构较为简单,同时电力系统总成本较低;当可靠性权重较大时,电力系统拓扑结构较为复杂但是成本较高。仿真结果表明,该方法能在成本、可靠性等指标中进行优化设计,体现出该方法在全电飞机电力系统设计初期具有较好的指导意义。

摘要：针对水面舰艇与潜艇对抗情况及其作战环境,为解决不同仿真器、模型之间的互操作及仿真组件的可重用性问题,提出了基于高层体系结构(HLA)的仿真系统设计方案,设计了由舰艇、潜艇、直升机、鱼雷等成员组成的舰潜对抗仿真系统,并就系统设计、开发及实现过程中所需解决的主要技术,如仿真系统框架结构设计、OMT设计、联邦成员实现、仿真应用与开发等分别作了讨论。此项研究对其它基于HLA的仿真系统的联邦设计与开发具有一定的参考价值。

摘要：对于迅速崛起的各种电子商务网站来说,为了促进网站发展和增加经济效益,吸引新客户并留住老客户是一种有效的手段.设计和实现高效的商品推荐算法是各大网站最为关注的技术之一.在电子商务网站中常见的一种推荐方式是以广告的形式在边栏推荐商品.目前,商品推荐系统根据推荐算法分为基于内容、协同过滤和混合的推荐系统.然而,现有推荐算法在电子商务网站的实际应用中正面临挑战,包括推荐结果的多样化、个性化和智能化以及时效化.现有算法需要不断改进来解决这些问题,从而完善电子商务推荐系统.

摘要：抚顺市万新大桥全长476.15m,主桥为15m+70m+160m+70m+15m的双塔双索面混凝土自锚式悬索桥.模型试验对万新大桥主桥模型的静力性能和动力特性进行了详细研究,并与理论计算结果进行了比较,模型试验结果与理论分析相吻合.试验表明中小跨度混凝土自锚式悬索桥的受力基本符合线弹性,可以用线弹性理论进行分析;用现有的有限位移理论分析混凝土自锚式悬索桥的静力和动力特性,并进行抗风、抗震设计是可靠的.