摘要：In an attempt to develop potent antitumor agents,new rhodacyanine analogues containing the pyridinium ring（5a-5h）,the isoquinolinium ring（6a-6c） and the quinolinium ring（7a-7e） linked to the rhodanine ring via N-N covalent bond were designed, synthesized and evaluated for antitumor activity against human lung cancer cell line（H460） by MTT assay in *** of the tested compounds showed enhanced antitumor activity with IC_（50） values ranging from 0.006 to 9.2 u,mol/L as compared to the lead compound *** them,the most promising compound 7d（IC_（50） = 0.006μmol/L） was 216.7 times more active than MKT-077（IC_（50） = 1.3μmol/L）.The preliminary structure-activity relationship of the target compounds was discussed.

摘要：中国科学院高能物理研究所第二台硼中子俘获治疗(BNCT02)加速器主要由1台离子源、1条低能束流传输线、1台射频四极加速器和3条高能束流传输线组成。为了保障BNCT02加速器的安全运行,设计了基于横河PLC和实验物理及工业控制系统(EPICS)软件工具包的机器保护系统。为了增强安全性,该系统采用了冗余设计,由两套完全独立且主要输入、输出信号一致的子系统构成。测试结果表明,BNCT02加速器机器保护系统的响应时间小于1.6 ms,且具有稳定可靠性高的特点,满足BNCT02加速器运行的需要。

摘要：内城新经济研究认为创意企业对网络组织更有依赖,但是对于网络的关键动力则众说纷纭。中国发达地区创意产业网络是否存在,其驱动机理在哪里?这正是研究初衷。以上海9个创意产业集聚区为研究区域,以创意设计业为研究对象,利用74份企业问卷和16家企业深度访谈采集数据,并运用SPSS统计分析工具进行研究。结果表明,基于投入产出关系的产业链分工协作仍然是网络驱动的重要逻辑,以人才、信息与知识流为核心的创意链正在形成。上下游企业协作有利于集体学习,它们之间的强联结对提高企业创意能力具有显著影响,然而从影响方式来看,关系内容远比关系强度更重要。"客户"和"高校"是地方网络的重要驱动主体,并以不同方式、不同程度地影响企业区位和创意能力。

摘要：当今大学对社会的影响不再局限于生产知识与培养人才,在地区持续繁荣和产业更新方面也发挥重要作用。通过对上海、北京两地94家创意设计企业的问卷调查,分析大学在发达城市创意生产系统中的实际功能。研究表明,大学对创意经济响应迅速,受其专业发展与经费筹集等内部利益驱动,以及企业需求与政府激励等外力助推,大学不再是地方发展的被动参与者,它们可以作为新产业的驱动者。除了担当企业和政府的决策智囊和人力资源库之外,大学还凭借其专业品牌、人力资本、社会资本等优势资源,通过提供资源与设施、师生创业,成为创意企业孵化器,其功能为其它机构难以替代。

摘要：Biomedical metals are widely used as implant materials in the human or animal body to repair organs and restore function, such as heart valves, meninges, peritoneum and artificial *** element affects the microstructure, mechanical property, corrosion resistance and wear resistance, but also influences the antibacterial and biological ***, antibacterial metal alloys have shown great potential as a new kind of biomedical materials, in which Cu has been widely used as antibacterial agent *** addition, biodegradable metal alloys, including magnesium alloy and zinc alloy, also have attracted much attention *** was also used as alloying element to adjust the degradation ***, the role of Cu in the alloy design will be very important for the development of new *** this paper, we summarized the recent research results on the Cu-containing metal alloy for biomedical application and hoped that this review would give more suggestions for the further development of biomedical metal alloy.

摘要：A series of sphere-rod shape amphiphiles were designed and synthesized by connecting the rod-like oligofluorenes with different lengths （OF,） to the different positions of the spherical [60]fullerene （C60） through a rigid linkage. The conjugates were characterized by IH-NMR, 13C-NMR, FTIR, EA and MALDI-TOF mass spectrometry. The optical and electronic properties of the conjugates were studied by UV-Vis absorption spectroscopy, fluorescence spectrometry, and cyclic voltammetry. The results from UV-Vis absorption spectroscopy and cyclic voltammetry indicated that the energy profiles of C60 and OFn remained unchanged when different lengths of OFn were attached to C60. The electron affinities of the OFn-C60 conjugates were close to that of C60, while slight electronic interaction was found between the two individual chromophores （C60 and OFn） in their ground states. The fluorescence spectra exhibited a complete fluorescence quenching in the toluene solution, suggesting an effective energy transfer from OFn to C60. It presents a systematic study on the self- assembly, structure-property relationship, and potential technical applications of the conjugates.

摘要：通过现场监测的方法,对沈阳某超深基坑的支护设计进行了研究.结果表明:该超深基坑采用桩锚支护方案,总体可行,但支护结构变形过大,安全储备不足,类似工程应采取相应措施来提高支护设计的安全性;附近地铁隧道开挖,对基坑稳定影响很小,支护设计可不予考虑;地基土冻胀对该基坑稳定性的影响不可忽略,是沈阳越冬基坑工程所要考虑的一个因素.研究结果为沈阳地区的超深基坑工程设计和施工提供了重要参考.

摘要：介绍了一种基于多目标遗传算法的电梯主动导轮系统集成结构和控制器优化设计方法。在本方法中,电梯主动导轮结构参数和主动控制器参数同时作为优化设计变量,电梯系统性能和控制代价作为优化设计目标。这是一个复杂的多目标优化问题。由于控制器具有特定的结构,多目标遗传算法直接被用来求解该多目标集成优化问题。这样不仅可以避免权函数的选择,而且一次运行就可以求出所有的Pareto最优解。最后用一个实验室比例电梯模型作为例子来说明该设计过程。

摘要：拓片作为我国特有的传统艺术形式,目前正面临着一系列尴尬问题。一方面,无论是其自身作为非物质文化宝贵遗产,还是对于文化艺术及其它领域的重要研究价值而言,拓片艺术都应当得到弘扬与发展。然而另一方面,拓片的传统制作方式又与珍贵文物的保护之间有着十分明显的矛盾和冲突。基于此,充分发挥艺术专业学科的优势,结合先进的计算机技术,提出了一套将浮雕物的"实物照片"转化成"数字拓片"的方案,并通过试验初步验证了该方案的有效性。

摘要：根据电梯横向振动的特点,建立了基于ADAMS的电梯虚拟样机模型。在此基础上分析了导轮系统弹簧刚度和阻尼对轿厢横向振动加速度以及导轮与轿架之间相对位移的影响,同时建立了以轿厢加速度和导轮与轿架之间相对位移的频率响应为目标的结构优化设计模型,并得到了结构优化设计参数。仿真试验表明:无论是频域还是时域,系统响应都得到了改善。