摘要：The present climate simulation and future projection of the Eastern Subtropical Mode Water （ESTMW） in the North Pacific are investigated based on the Geophysical Fluid Dynamics Laboratory Earth System Model （GFDL-ESM2M）. Spatial patterns of the mixed layer depth （MLD） in the eastern subtropical North Pacific and the ESTMW are well simulated using this model. Compared with historical simulation, the ESTMW is produced at lighter isopycnal surfaces and its total volume is decreased in the RCP8.5 runs, because the subduction rate of the ESTMW decreases by 0.82×10？6 m/s during February–March. In addition, it is found that the lateral induction decreasing is approximately four times more than the Ekman pumping, and thus it plays a dominant role in the decreased subduction rate associated with global warming. Moreover, the MLD during February–March is banded shoaling in response to global warming, extending northeastward from the east of the Hawaii Islands （20°N, 155°W） to the west coast of North America （30°N, 125°W）, with a max-imum shoaling of 50 m, and then leads to the lateral induction reduction. Meanwhile, the increased north-eastward surface warm current to the east of Hawaii helps strengthen of the local upper ocean stratification and induces the banded shoaling MLD under warmer climate. This new finding indicates that the ocean surface currents play an important role in the response of the MLD and the ESTMW to global warming.

摘要：The present climate simulation and future projection of the mixed layer depth(MLD)and subduction process in the subtropical Southeast Pacific are investigated based on the geophysical fluid dynamics laboratory earth system model(GFDL-ESM2 M).The MLD deepens from May and reaches its maximum(>160 m)near(24°S,104°W)in September in the historical *** MLD spatial pattern in September is non-uniform in the present climate,which shows three characteristics:(1)the deep MLD extends from the Southeast Pacific to the West Pacific and leads to a"deep tongue"until 135°W;(2)the northern boundary of the MLD maximum is smoothly near 18°S,and MLD shallows sharply to the northeast;(3)there is a relatively shallow MLD zone inserted into the MLD maximum eastern boundary near(26°S,80°W)as a weak"shallow tongue".The MLD nonuniform spatial pattern generates three strong MLD fronts respectively in the three key regions,promoting the subduction *** global warming,the variability of MLD spatial patterns is remarkably diverse,rather than deepening *** all the key regions,the MLD deepens in the south but shoals in the north,strengthing the MLD *** a result,the subduction rate enhances in these *** MLD antisymmetric variability is mainly influenced by various factors,especially the potential-density horizontal advection non-uniform *** that the freshwater flux change helps to deepen the MLD uniformly in the whole basin,so it hardly works on the regional MLD *** study highlights that there are regional differences in the mechanisms of the MLD change,and the MLD front change caused by MLD non-uniform variability is the crucial factor in the subduction response to global warming.

摘要：以金刚烷苯乙烯为结构单元,设计合成了3个含有亲水性基团的新型小分子(8a、8b和8c),利用核磁共振谱、红外光谱和高分辨质谱等技术手段对其进行了结构表征。用1-溴代金刚烷作为原料在Pd/C和K2CO3的作用下发生傅克烷基化反应高产率得到金刚烷甲苯(2),随后在N-溴代琥珀酰亚胺(NBS)和(三苯基膦烯基)乙酸甲酯过氧化苯甲酰(BPO)的作用下发生溴代反应得到了金刚烷苄基溴的化合物3,苄基溴在酸性条件下氧化生成醛(4),该醛与维蒂希试剂发生Wittig反应得到甲酸甲酯(5),随后发生碱性条件水解得到重要的中间体6。最后该中间体与3个结构不同的苯胺类化合物发生偶联反应生成了3个目标化合物。通过MTS法评价了3个化合物对人肝癌细胞(SMMC7721)、乳腺癌细胞(MCF-7)、宫颈癌细胞(Hela)、肺癌细胞(A549)的增殖抑制活性。结果表明,部分化合物表现出较好的抑制活性。其中,目标化合物8c对人肝癌细胞表现出较好的抗肿瘤活性(IC_(50)=1.6μmol/L或0.73 mg/L),与现有药物阿霉素相当(0.44 mg/L),有望成为潜在的抗肿瘤药物分子。该类化合物可能在靶向抗肿瘤药物研发方面具有较好的研究前景,所合成的金刚烷苯乙烯类衍生物的抗肿瘤活性、靶点及作用机制还有待进一步研究。

摘要：文章旨在通过包头职业技术学院“第二课堂成绩单”制度实施情况,研究高校第二课堂活动课程化设计与实施,对第二课堂活动从课程体系设计、教学活动设计、教学效果评价方面进行课程化设计,从而保障高校第二课堂活动有效开展。

摘要：通过将商用车底盘线束按照整车结构、区域进行合理划分,对同区域线束布置方案进行精细化设计,对模块化线束3D文件进行建库管理,将整根主线束的三维布置设计工作拆分为各个基础线束模块的设计及拼接工作,有效减少线束结构种类,提升设计效率,降低管理成本,提升整车线束布置可靠性。

摘要：随着复合绝缘子挂网运行时间的增加,复合绝缘子的老化日趋严重。为了方便快捷地检测复合绝缘子的老化程度,文中根据复合绝缘子伞裙护套的结构特点,设计了一种U型的便携式低场核磁共振传感器。测量样品为挂网运行不同时间的硅橡胶复合绝缘子,采用CPMG脉冲序列激励,得到样品的CPMG回波衰减数据。对CPMG回波衰减数据进行双指数函数拟合分析,得到硅橡胶伞裙材料的等效横向弛豫时间参数:t2,short和t2,long。实验结果表明,硅橡胶伞裙的t2,long参数与其老化程度有很好的对应关系,具体表现为随着绝缘子老化程度的加剧,横向弛豫时间t2,long逐渐减小。