摘要：阿尔茨海默症(Alzheimer's Disease,AD)是一种非常常见的进行性和破坏性中枢神经系统的退行性疾病,对老年人的生活质量产生影响,对老年人的生命安全造成严重危害,给家庭、社会和国家带来了巨大的经济负担。目前治疗AD的药物尚未取得较大突破和创新,面临着突破血脑屏障的挑战,且治疗方法不当可能会导致患者产生不良反应。靶向载药系统作为一种有效的治疗方式,能够显著降低血液中的药物浓度、给药频率和药物毒副作用,同时提高药物在目标部位的浓度和疗效以及药物生物利用度,还能对药物起到缓释效果。此外,靶向载药系统还有望穿透血脑屏障,提高血脑渗透率,实现脑靶向性,精准递送药物,从而为治疗AD提供了一条高效且安全的途径。本工作综述了AD的发病机制、AD的治疗辅助药物、非药物治疗方法以及针对Aβ聚集、乙酰胆碱酶抑制和受体拮抗等主要药物的作用机理和副作用,并对磁性纳米颗粒、脂质体等针对治疗AD的靶向载药系统进行了简单的介绍、梳理及总结,指出了现在存在的问题,提出了可能的解决方案,指明了未来可能发展的方向。

摘要：To understand fundamental problems in hypersonic laminar-turbulent boundary layer transition for three-dimensional complex vehicles,a new standard model with typical lifting-body features has been proposed,named as hypersonic transition research vehicle(HyTRV).The configuration of HyTRV is fully analytical,and details of the design process are discussed in this *** transition characteristics for HyTRV are investigated using three combined methods,i.e.,theoretical analyses,numerical simulations,and wind tunnel *** show that the fully analytic parameterization design of HyTRV can satisfy the model simplification requirements from both numerical simulations and wind tunnel ***,the flow field of HyTRV reveals typical transition mechanisms in six relatively separated regions,including the streamwise vortex instability,crossflow instability,secondary instability,and attachment-line ***,the proposed HyTRV model is valuable for fundamental researches in hypersonic boundary layer transition.

摘要：The NI （non-inferiority） trial design based on the likelihood ratio test eliminates the dependency on the conventional NI margin, and it explicitly uses the MCID （minimum clinical important difference） that links the statistical analysis to the clinical sense. Different from the conventional trial design, the new methodology is self-adaptive to the change in the sample size and overall cure rate, and it has an asymptotic property. It is shown that MCID is de-composite into constant MCID and statistical MCID. Along with this concept, the concept of the allowed inferiority does not exist, the interpretation of the trial result is more accurate and consistent to the statistical theory as well as the clinical interpretations.

摘要：A fully integrated low noise amplifier( LNA) for WLAN 802. 11 ac is presented in this article.A cascode topology combining BJT and MOS transistor is used for better performance. An inductive source degeneration is chosen to get 50 Ohm impedance matching at the input. The noise contribution of common gate transistor is analyzed for the first time. The designed LNA is verified with IBM silicon-germanium(SiGe ) 0. 13μm BiCMOS process. The measured results show that the designed LNA has the gain of 13 dB and NF of 2. 8 dB at the center frequency of 5. 5 GHz. The input reflection S11 and output reflection S22 are equal to-19 dB and-11 dB respectively. The P-1 dB and IIP3 are-8. 9 dBm and 6. 6 dBm for the linearity performance respectively. The power consumption is only 1. 3 mW under the 1. 2 V supply. LNA achieves high gain,low noise,and high linearity performance,allowing it to be used for the WLAN 802. 11 ac applications.

摘要：Chlorothiazole ring, as a substituted heterocycle, frequently occurred in structures of various insecticides, and brought positive effect on bioactivity. In purpose to find novel neonicotinoids, a series of pyrrole- and dihydropyrrole-fused neonicotinoid analogs containing chlorothiazole ring were synthesized for the first time. Results of the following biological assays showed that compounds Sa-c achieved good insecticidal activity against Aphis craccivora, and compound Sh exhibited good activity against Nilaparvata lugens.

摘要：Working principles of silicon double P-N junction color sensor are introduced and a color measurement system to distinguish tooth color difference is designed in this *** system consists of silicon double P-N junction,a small optical fiber probe,signal process circuit and an MSP430FG439 single-chip *** in size,this system can measure different parts of the tooth in a fast and convenient way with ***,this system will be very promising in building prosthodontics and tooth fabrication.

摘要：The Chinese global carbon dioxide monitoring satellite （TanSat） was launched successfully in December 2016 and has completed its on-orbit tests and calibration. TanSat aims to measure the atmospheric column-averaged dry air mole fractions of carbon dioxide （XCO2） with a precision of 4 ppm at the regional scale, and in addition, to derive global and regional CO2 fluxes. Progress towards these objectives is reviewed and the first scientific results from TanSat measurements are presented. TanSat on-orbit tests indicate that the Atmospheric Carbon dioxide GratingSpectrometer is in normal working status and is beginning to produce LIB products. The preliminary TanSat XCO2 products have been retrieved by an algorithm and compared to NASA Orbiting Carbon Observatory-2 （OCO-2） measurements during an over- lapping observation period. Furthermore, the XCO2 retrievals have been validated against eight groundsite measurement datasets from the Total Carbon Column Observing Network, for which the preliminary conclusion is that TanSat has met the precision design requirement, with an average bias of 2.11 ppm. The first scientific observations are presented, namely, the seasonal distributions of XCO2 over land on a global scale.

摘要：Candida albicans （C. albicans） infection has a high mortality rate in immunocompromised patients. Owing to the inefficiency of the current diagnostic system and the absence of licensed vaccines against candidiasis, the prevention of C. albicans infection remains a challenge. C. albicans infection can be evaluated and prevented by the anti-secreted aspartyl proteinase 2 antibody （anti-Sap2 IgG） and Hsp90 antibody （anti-Hsp90 IgG）. In this study, to explore a new agent for the improvement of the diagnosis and the prevention of C. albicans infection, an engineered fd bacteriophage, which is considered a human-safe virus nanofiber, was designed and prepared with two epitopes that could induce and capture anti-Sap2 IgG and anti-Hsp90 IgG. The dual-display phage was employed as a novel capture probe to develop a new enzyme-linked immunosorbent assay （ELISA） method, which significantly improved the detection rate compared with those of the ELISA in which recombinant protein Sap2 was used as coating antigen to capture the spedfic antibodies （rSap2-ELISA） and the ELISA in which recombinant protein Hsp90 was used as coating antigen to capture the specific antibodies （rHsp90-ELISA）. In addition, the nanofibers acted as a potential vaccine to immunize mice, as well as recombinant proteins, more efficiently mediated humoral and cellular immune responses, decreased levels of C. albicans colonization, and increased the survival rates in C. albicans-infected mice. Therefore, the phage dual-display nanofiber has been shown to be a powerful bifunctional agent for protection against and sensitive detection of clinical infections, which has the potential to be widely used in the life sciences, clinical medicine, and environmental sciences.

摘要：核电站安全制动器基于高精度、高可靠性设计,而摩擦片是安全制动器功能执行的核心零件,其摩擦性能影响核电站设备的安全性和经济性.本文作者将椭圆织构应用于安全制动器的摩擦片中,通过数值方法研究了椭圆织构摩擦片在电磁制动器中的作用机理;建立椭圆织构摩擦片分析模型,同时利用有限元法求解摩擦片端面的压力分布情况,并研究了椭圆倾斜角、长细比、织构深度和摩擦面间隙变化对压力分布的影响规律.结果表明:增加椭圆织构的长细比可以有效地降低摩擦面的磨损;椭圆织构倾斜角为45°时,气膜承载力最大,可以有效降低摩擦面的磨损;椭圆织构太深或太浅均会增加摩擦面的磨损,当深度为1μm时,可以起到很好的减磨效果;椭圆织构产生较大的气膜承载力从而增大间隙,但气膜承载力随摩擦片间隙增加而减小,因而使摩擦片间隙固定在一定范围,既减少了磨损又保证了设备的稳定运行.本文中涉及的数值研究为完善电磁制动器中的椭圆织构摩擦片设计提供解决方法,后续在产品样机中应用并通过了寿命试验验证.

摘要：液晶聚合物能够在外界刺激下发生形状变化,是一类重要的柔性智能材料。其中液晶有序排列的改变诱导材料的宏观形变。光响应聚合物具有可远程操作、易于控制等特点,在刺激响应性聚合物的设计中受到了广泛关注。将具有光响应性的基团引入到液晶聚合物体系中,可以得到一系列具有重要应用前景的光致形变材料。本文综述了近年来光响应形变液晶聚合物的研究进展,总结了光响应液晶聚合物的分子设计与响应原理,包括光致异构化响应型、光致生热响应型和多重刺激响应型;介绍了光响应液晶聚合物柔性执行器在仿生功能、能量转换和柔性机器人等领域的应用;展望了未来的研究方向与应用前景。