摘要：Introduction Despite the numerous breakthroughs made in medical and biomedical technologies,biosensing underneath the skin without any associated pain still sounds like a dream yet to be *** invasive biosensors refer to functional or electronic sensors that can contact the interior environment of living organisms and their biological tissues,while the connected bulk devices remain on the surface of the biological objects[1].Minimally invasive biosensors are currently a key research area because they can not only meet the increasing technical demands to precisely detect biological activities inside biological objects,but also provide an ideal platform to externally incorporate complicated functionalities and electronic integration[2].The current development level of minimally invasive sensing still necessitates solving the constraints and bottlenecks in the three aspects of functionalities,sensitivity and biocompatibility[3].In this perspective,we select minimally invasive sensors as a representative research object with the aim to solve the limitations of current diabetes diagnosis and treatment approaches.

摘要：Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in *** glucose monitoring based on implantable electrodes could induce pain and potential tissue inflammation,and the presence of reactive oxygen species(ROS)due to inflammationmay affect glucose *** technology is less invasive,yet microneedle adhesion with skin tissue is *** this work,we developed a microarrow sensor array(MASA),which provided enhanced skin surface adhesion and enabled simultaneous detection of glucose and H_(2)O_(2)(representative of ROS)in interstitial fluid in *** microarrows fabricated via laser micromachining were modified with functional coating and integrated into a patch of a three-dimensional(3D)microneedle *** to the arrow tip mechanically interlocking with the tissue,the microarrow array could better adhere to the skin surface after penetration into *** MASA was demonstrated to provide continuous in vivo monitoring of glucose and H_(2)O_(2) concentrations,with the detection of H_(2)O_(2) providing a valuable reference for assessing the inflammation ***,the MASA was integrated into a monitoring system using custom *** work provides a promising tool for the stable and reliable monitoring of blood glucose in diabetic patients.

摘要：Modern medicine is increasingly interested in advanced sensors to detect and analyze biochemical *** sensors based on potentiometric methods are a promising platform for monitoring physiological ions in biological *** semi-implantable devices are mainly based on single-parameter *** semi-implantable electrodes for multiparameter sensing have more restrictions on the electrode size due to biocompatibility considerations,but reducing the electrode surface area could potentially limit electrode *** study developed a semi-implantable device system comprising a multiplexed microfilament electrode cluster(MMEC)and a printed circuit board for real-time monitoring of intra-tissue K^(+),Ca^(2+),and Na^(+)*** electrode surface area was less important for the potentiometric sensing mechanism,suggesting the feasibility of using a tiny fiber-like electrode for potentiometric *** MMEC device exhibited a broad linear response(K^(+):2–32 mmol/L;Ca^(2+):0.5–4 mmol/L;Na^(+):10–160 mmol/L),high sensitivity(about 20–45 mV/decade),temporal stability(>2weeks),and good selectivity(>80%)for the above *** vitro detection and in vivo subcutaneous and brain experiment results showed that the MMEC system exhibits good multi-ion monitoring performance in several complex *** work provides a platform for the continuous real-time monitoring of ion fluctuations in different situations and has implications for developing smart sensors to monitor human health.

摘要：随着微纳加工技术和新材料工艺的不断创新,应用于疾病诊断和治疗的电子器件呈现出小型化、柔性化和多功能化的发展趋势.在医学诊断和治疗领域,微创电子器件发挥着越来越重要的作用.微创诊断电子器件提供了靶向引导、手术监控和连续性诊断等功能,为组织病变的原位诊断提供了有效手段.微创治疗电子器件通过个性化调控的方式,为疾病治疗提供了多种选择,显著降低了患者的生理损伤和术后风险,提高了患者的康复速度.本文综述了应用于组织病变微创诊断与治疗的微纳电子器件的类型、特征及其设计思路,并从生化诊疗和物理诊疗技术的角度对其进行技术分析.最后,讨论了目前微纳电子器件在疾病微创诊断和治疗应用中面临的挑战与机遇.

摘要：伦敦地铁是全球最发达的地铁网络之一,有着欧洲最大、世界上最古老的地铁系统。从伦敦地铁开始,世人认识到地下空间的主要交通方式——地铁是改善地面交通拥挤最好的解决方案。但如果没有一个规范的地铁视觉传达系统,势必给人们出行带来不便,而且会阻碍到社会和经济等领域的发展。笔者根据在伦敦生活的切身感受以及对相关资料的研究,对伦敦地铁在视觉传达设计方面表现出的英国特色和城市精神进行了比较深入的探讨,同时对比南京地铁现有的视觉传达设计,分析了各自的特点,提出了重视地铁设计文化,彰显城市文化和城市精神等问题。

摘要：本文通过论述国外发达国家高等学校普遍重外国留学生教育工作的经验,提出我院在发展过程中,应当更加重视国际间的交流与合作,进一步加强外国留学生教育教育工作,并在学科建设、留学生的本科生教育和研究生教育方面提出了自己的一些设想,以期使我院留学生教育工作迈上一个新的台阶。

摘要：本文从英国《动物战士》纪念碑出发,阐述了人与动物的关系、尊重生命伦理的必要性以及艺术的表现对象等问题。

摘要：在旅游+视角下,以李白诗歌文化为研究方向,整合集李白诗歌文化研究、动漫产业创新、动漫周边生产创作、旅游推广于一体的李白诗歌文化动漫旅游产业,塑造李白动漫品牌,培育安徽动漫旅游产业新业态,以期促进安徽地方文化与旅游业的创新融合,为安徽地方李白文化保护和传播提供创新发展思路,实现李白文化的价值转变,推动安徽地区旅游经济发展,同时填补相关学术研究空白。

摘要：古籍《清嘉录》包含了丰富的岁时礼制习俗,是中国风土民俗文化研究的重要文本依据。一方面,借助于新媒体全民化、图像化、多元化的传播特征进行表达;另一方面,依靠“检视—提炼—转译—传递—评价”的多元形式构建,对“存在—突破—创新”的复合性传播模式进行阐释。新媒体数字时代的发展为古籍出版方式的变革带来了机遇,融合新媒体的出版方式更加有利于文化古籍的继承与创新,以视觉转译的角度提出文化古籍在当下数字时代的传播策略与方法,是对现有优质文化资源数字化创意转化与开发的助力尝试。

摘要：由于原子间存在共价键、金属键与离子键的混合键合状态,MAX相陶瓷兼具金属和陶瓷材料的性能特点,并且常与金属之间表现出良好的润湿性,有助于形成强界面结合,独特的层状原子结构使MAX相陶瓷表现出良好的断裂韧性、阻尼与自润滑性能。因此,作为金属基复合材料的增强相,MAX相陶瓷具有显著优势,本文着重介绍相关研究进展。目前,MAX相陶瓷增强金属基复合材料主要通过搅拌铸造、粉末冶金和熔体浸渗等途径制备,得到的复合材料表现出优于金属基体的强度、硬度与模量,同时还具备良好的耐磨、导电、抗电弧侵蚀等性能。此外,借助真空抽滤、冰模板等工艺可实现超细片状MAX相陶瓷粉体的择优定向排列,然后利用金属熔体浸渗多孔陶瓷骨架,可获得具有类贝壳结构的MAX相陶瓷增强金属基仿生复合材料,进一步提升材料的强韧性能。MAX相陶瓷增强金属基复合材料在承载、电接触等应用领域具有显著优势和广阔前景。