摘要：Abstract Meniscus injury is a common disease in *** it was not treated in time,it leads to osteoarthritis which brings unbearable pain and heavy economic burden to the *** present,meniscectomy and meniscus suture are widely used in the treatment for meniscus ***,It is not ideal for poor self-healing ability of *** recruitment of endogenous stem cells is an attractive option for wounded meniscus *** reduced high-mobility group box 1 protein(HMGB1)can accelerate the regeneration of multiple tissues by endogenous stem cell activation,migration and ***(KGN)has shown to induce the chondrogenesis of the stem ***,no study has explored such effects of HMGB1 and KGN in wounded meniscus ***,in order to improve the regeneration of meniscus,we intend to use a novel bioactive microsphere which was developed by combining fully reduced high mobility group box 1(frHMGB1)and kartogenin(KGN)with alginate gel which slowly release high concentrations of HMGB1 and KGN to activate rat bone marrow stem cells(BMSCs)and promote cell *** results showed that this HMGB1–KGN microsphere released and kept high concentrations of HMGB1 and KGN in the wound area for more than 2 *** vitro experimental results showed that the HMGB1–KGN microsphere can promote cell proliferation via recruiting rat bone marrow stem cells(BMSCs)and activating the BMSCs from G_(0) to G_(Alert) stage as evidenced by cell migration testing and 5-bromo-2′-deoxyuridine(BrdU)incorporation *** vivo results indicated that this HMGB-KGN microsphere can recruit GFP-labeled BMSCs from tail vein to wounded meniscus and induce these GFP-labeled BMSCs to differentiate into *** results demonstrated that the HMGB1–KGN-containing bioactive microsphere induced cell migration in vitro and recruited the cells to wound area to promote wounded rat meniscus healing in vivo.

摘要：北极运输船舶常航行于由破冰船开辟的碎冰航道中;尽管这避免了船舶与层冰碰撞引起的巨大冰阻力,但船舶与航道中碎冰的相互作用受到两侧层冰的影响,进而会对船舶的航行性能产生影响。目前,碎冰航道两侧层冰对船舶航行性能的影响尚未得到充分研究,是否考虑这一影响是北极船舶设计的一个重要问题,采用CFD-DEM(computational fluid dynamics-discrete element method)耦合方法模拟船舶在碎冰航道中的航行过程并分析船-碎冰相互作用特点,进而对船舶阻力进行数值预报。首先,开展了网格和时间步长的收敛性分析以评估数值误差和不确定度,验证了数值模型的可靠性;在此基础上的预报结果表明,由于两侧层冰对船舶兴波产生影响,船舶水阻力随航道宽度的减小而小幅增大且主要为压阻力的增加;船舶冰阻力随航道宽度的减小而迅速增大,船体两侧的碎冰堆积现象是导致冰阻力增大的主要原因。

摘要：针对铸态铁素体基硅钼球铁的特殊要求,通过设计适宜的化学成分,采用合理的球化孕育工艺及冷却速度等措施进行试验,稳定地获得了珠光体含量≤5%、碳化物≤1%及伸长率≥15%的硅钼球铁,并进行了生产性试验验证。

摘要：为解决稻、鱼、鸭共生的难题,提出了一种水稻种植下混养鱼鸭的技术方案,并于2019-2020年在湖南省长沙县路口镇实施。通过2年的观察发现,"稻-鱼-鸭"共生模式保证水稻生长发育的同时,也保持了鱼的水下生存环境及鸭的田间、水面活动空间;通过鱼鸭的活动及捕食,能有效防控田间病虫草害的发生,减少除草剂的施用;同时鱼鸭的粪便能够直接还田减少肥料的施用,对提高土壤养分含量、减轻农田污染有着重要作用;稻田中的深水域还有蓄水、缓解灌溉水短缺等作用。"稻-鱼-鸭"共生模式具有明显的经济效益、生态效益及社会效益。

摘要：优化了以桑叶和麸皮为主要原料由毛云芝菌(Coriolus hirsutus)生产漆酶的培养条件,即培养料起始pH、装料量、封口情况、接种量、发酵时间对漆酶活性的影响,并观察了该菌在优化后培养条件下的代谢动力学情况。结果表明,自然pH,装量为10 g/250 mL三角瓶、封口纱布4层,接种量为5 mL种子液/瓶,培养时间为10 d,酶活达到1.37×104U,优化后结果比初始设计提高了18%。