摘要：Aircraft conceptual design optimizations that maximize the performance at a design condition （single-point） may result in designs with unsatisfying off-design performance. To further improve aircraft efficiency under actual flight operations, there is a need to consider multiple flight conditions （multipoint） in aircraft conceptual design and optimization. A new strategy for multipoint optimizations in aircraft conceptual design is proposed in this paper. A wide-body aircraft is taken as an example for both single-point and multipoint optimizations with the objective of maximizing the specific hourly productivity. Boeing 787-8 flight data was used in the multipoint opti- mization to reflect the true objective function. The results show that the optimal design from the multipoint optimization has a 7.72% total specific hourly productivity increase of entire flight missions compared with that of the baseline aircraft, while the increase in the total specific hourly productivity from the single-point optimal design is only 5.73%. The differences between the results of single-point and multipoint optimizations indicate that there is a good option to further improve aircraft efficiency by considering actual flight conditions in aircraft conceptual design and optimization.

摘要：Based on the active site of lanosterol 14α-demethylase of azole antifungal agents,sixteen 1-（1H-1,2,4-triazole-1-yl）- 2-（2,4- difluorophenyl）-3-（N-n-butyl-N-1-substitutedbenzyl-4-methylene-1H-1,2,3-triazole）-2-propanols have been designed,synthesized and evaluated as antifungal *** of preliminary antifungal tests against eight human pathogenic fungi in vitro showed that some of the compounds exhibited excellent activities with broad spectrum.

摘要：A series of 1-（1H-1,2,4-triazole-1-yl）-2-（2,4-difluoropheny1）-3-（N-isoproy1-N-substituted-amino）-2-propanols have been designed and synthesized on the basis of the active site of lanosterol 14a-demethylase （CYP51）. Their structures were confirmed by MS and ^1H NMR. In vitro antifungal activities of these synthesized compounds were evaluated against eight human pathogenic fungi. The results showed that all title compounds exhibited activity against fungi tested to some extent. Compounds 3c, 3d, 7a, 7b and 7e exhibited more potent antifungal activities against nearly all fungi tested except AspergiUus fumigatus than fluconazole. ？2009 Qiu Ye Wu. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All fights reserved.

摘要：提出了一种在网格内部采用线性源分布的特征线方法,并且编写了线性源特征线方法程序TCM_L。数值计算结果表明,线性源特征线方法的计算精度高于平源特征线方法和简化线性特征线格式SLC;使用大网格计算的线性源特征线方法在保证计算精度的同时可以节省大量的存储空间和计算时间。

摘要：介绍了开发的三维中子输运特征线方法程序TCM,使用数值实例对TCM的准确性进行了验证,同时比较了不同插值阶数、离散角度数目和网格大小对计算结果的影响。结果表明,三维特征线方法程序TCM能够求解任意几何形状及反射边界条件的中子输运问题,计算结果具有较高的精度。

摘要：特征线方法在处理三维中子输运问题的反射边界条件时存在空间问题和角度问题,本文提出了采用平面插值和球面插值方法来分别处理这两个问题,插值方法不仅可以有效解决空间问题和角度问题,而且三维特征线方法在采用插值方法处理边界条件后对离散求积组和射线布置没有要求。

摘要：对一种设计马赫数为5的一级二元混压式进气道再入大气层过程典型状态进行了仿真和风洞试验,得到了该进气道典型状态下的气动特性.结果表明:当来流马赫数高于设计马赫数(为5)时,进气道外压斜激波系提前汇合,与唇罩入射斜激波相互作用,产生了波-波干扰;尽管发生了流动分离,但当来流马赫数为7和6时进气道出口上游气流紊流度分别不超过3.337和3.256,且流道内动态压力信号的功率谱密度呈现白噪声特征,不会对发动机造成结构损伤.因此,对于宽来流马赫数工作范围的进气道来讲,为了提供足够的流量,可以适当降低进气道的设计马赫数.

摘要：山西介休后土庙"麒麟闹八宝"琉璃影壁心,构图设计匀称饱满,元宝、钱串(吊钱)、犀角杯、如意、双圈(圆胜)、珊瑚、海螺、双菱(方胜)"八宝"及象征"福、禄、寿、喜"的蝙蝠、绿草、松树和喜鹊环绕于麒麟周围,错落有致,繁而不乱,装饰效果极佳,并寓意喜庆吉祥。从春秋战国到今天,麒麟文化已经成为中国传统文化的重要组成部分,其造型也在不断发展和变化。

摘要：针对超临界水冷反应堆(SCWR)堆芯冷却剂密度沿轴向变化剧烈的特点,开发用于SCWR堆芯稳态物理-热工水力耦合计算的程序系统CASIR。CASIR由改进的压水堆堆芯中子学计算程序和适用于SCWR燃料组件计算的子通道热工-水力程序组成,具备调整堆芯下腔室入口流量分配的功能。针对CSR1000双流程的SCWR首循环堆芯,通过与蒙特卡罗程序对比寿期初时刻计算结果的方式,初步验证CASIR计算SCWR堆芯中子学问题的准确性;通过SCWR堆芯燃耗模拟,以及调整堆芯流量分布使得最大包壳表面温度(MCST)满足设计限值的测试,表明CASIR满足SCWR堆芯设计的要求,可应用于方形燃料组件的SCWR堆芯概念设计。

摘要：在翼身融合布局客机总体设计阶段,为评估设计方案的总体性能,建立了翼身融合布局客机总体参数综合分析与优化平台,该平台以翼身融合布局客机的几何参数为输入,完成动力、几何、重量、气动、性能和经济性等模块分析,并以此为基础建立优化设计模型。为快速评估设计方案的性能及优化设计效果,动力分析模块采用了部件级分析模型,重量分析模块采用半经验估算方法,气动分析模块采用面元法结合工程估算方法,性能分析模块采用简化运动学方法,优化模型采用可并行计算的子集模拟优化算法。以某555座级翼身融合布局客机方案为例,应用开发的分析与优化平台,完成了总体参数分析,结果表明分析模型合理。在此方案的基础上,以客机的外形参数和发动机海平面最大推力为设计变量,分别建立了以最大起飞重量最小为目标的单目标优化,以及同时以直接使用成本和进场速度最小为目标的多目标优化,单目标优化结果最大起飞重量降低了约7.17%,多目标优化结果表明直接使用成本降低8.77%的同时进场速度会增加3.32%。