摘要：背景:生物材料植入体内后引发的异物反应会导致其被纤维组织包裹,阻碍植入物与宿主组织的相互作用,损害植入物的功能,进而缩短其寿命。目的:重点讨论生物材料异物反应的调控策略进展,包括基于生物材料表面改性、药物递送和仿生表面修饰的策略,同时探讨了这些方法的优势和局限性。方法:应用计算机在PubMed、Wiley、EBSCOhost、ScienceDirect和Elsevier数据库检索2000年1月至2024年3月期间的相关文献,以“biological materials,foreign body reaction,fibrosis,macrophage,myofibroblasts,inflammation,regulation,tissue repair”为检索词,最终纳入69篇文献进行分析。结果与结论:通过调整生物材料的表面特性(例如尺寸、形状、粗糙度、表面电荷、亲水性以及机械刚度等)能够减轻其对免疫系统的刺激,进而降低发生异物反应的风险;通过可控量的药物刺激产生持久的化学反应,结合使用可控降解的载体材料,可以减轻异物反应;生物材料仿生表面修饰(如两性离子涂层、蛋白质分子涂层等生物活性分子涂层)在短期能有效减轻异物反应。由于植入物和组织再生的免疫反应具有复杂性,在设计和制造植入物时也应考虑异物反应和组织再生之间的整体平衡。

摘要：Thanks to the fast improvement of the computing power and the rapid development of the computational chemistry and biology,the computer-aided drug design techniques have been successfully applied in almost every stage of the drug discovery and development pipeline to speed up the process of research and reduce the cost and risk related to preclinical and clinical *** to the development of machine learning theory and the accumulation of pharmacological data, the artificial intelligence(AI) technology, as a powerful data mining tool, has cut a figure in various fields of the drug design, such as virtual screening,activity scoring, quantitative structure-activity relationship(QSAR) analysis, de novo drug design, and in silico evaluation of absorption, distribution, metabolism, excretion and toxicity(ADME/T) properties. Although it is still challenging to provide a physical explanation of the AI-based models, it indeed has been acting as a great power to help manipulating the drug discovery through the versatile frameworks. Recently, due to the strong generalization ability and powerful feature extraction capability,deep learning methods have been employed in predicting the molecular properties as well as generating the desired molecules,which will further promote the application of AI technologies in the field of drug design.

摘要：新工科背景下的复合型人才培养需要学科的交叉融合。以学科交叉为切入点,对无机及分析化学实验课程实验教学进行了改革和实践。以校内自来水和生活污水作为测试对象,采用高锰酸钾法测定了水样的化学需氧量。通过实验旨在提高学生的实践动手能力、跨学科思维能力、数据收集计算能力以及解决实际问题能力,增强学生环境保护意识,适合为化学、环境工程和资源循环科学与工程等专业学生开课。问卷调查发现,学生和教师对该实验内容都给予了高度评价,教学实践效果良好。

摘要：基于量子化学计算软件Gaussian 16,对“电动势的测定”这一经典物理化学实验进行了计算化学设计。用密度泛函方法计算了Cu^(2+)和Zn^(2+)的溶剂化自由能,通过热力学循环计算得到电池反应的标准摩尔吉布斯自由能变,进而求出Cu-Zn原电池的标准电动势。该实验旨在帮助学生加深对标准摩尔吉布斯自由能、电极电势和能斯特方程等物理化学基本概念的理解,发挥学生的主观能动性,培养学生设计实验能力、动手实践能力以及科学思维。

摘要：本文阐述了明清时期扬州民居门楼的建筑特点并对其进行分类,探讨其装饰艺术特征和设计文化的丰富内涵,为扬州古民居的保护与开发提供参考。

摘要：由中国家具协会和广东家具协会共同主办、由享有＂中国家具制造重镇＂和＂中国家具材料之都＂双重美誉的顺德龙江镇政府协办的第二届——2012年度＂龙＂家具创意设计大赛通过半年多的发动、征集和评审,最终从1829件作品里评审出各40入围的学生组和专业组的优秀作品,进行实物打样和实物评审阶段,参与最后的奖项角逐。

摘要：Future projection of diffusion conditions associated with extreme haze events over eastern China is of great importance to government emission regulations and public human ***,the diffusion conditions and their changes under future warming scenarios are *** relative strength of haze events in the Northern China Plain region increase from 150%during 2006–15 to 190%during 2090–99 under RCP8.5 scenarios,induced by a stronger and longer-lasting anticyclone anomaly in eastern *** strengthened anticyclone anomaly is mainly induced by increased northern wave train convergence emanating from the Barents–Kara Sea,and the longer duration of the anticyclone anomaly is mainly induced by stronger local feedback that can extract more energy from the basic state to maintain the anticyclone anomaly in eastern *** reduction is found to play a dominant role in strengthening the upstream wave train near the Barents–Kara Sea and the downstream anticyclone in eastern China,while the effects from increased greenhouse gases are *** results of this study indicate that future aerosol emissions reduction can induce deteriorating diffusion conditions,suggesting more stringent regulations on aerosol emissions in China are needed to meet air quality standards.

摘要：从工业园、数码园到文化艺术园区,遍地开花的创意产业园区已经成为城市的一种发展趋势。创意产业园区的发展不仅能够推动创意产业的发展,而且对于创意城市的形成和发展也具有全面的推动作用。它可能是一片旧厂房,也可能是一块曾被忽略的远郊空地,但一经"创意"改造,就有"麻雀"变"凤凰"的吸金魔力。

摘要：当前我国动漫业面临着可持续、高质量发展的问题,作为对产业发展具有重要影响的动漫产业政策要改变过去的“全能政府”倾向,朝着强化有限政府理念,尊重市场机制的主导性方向优化。具体包括:政府部门减少管制思维,增强为市场主体服务的意识,改变扶持策略,将政策重心调整到为动漫企业发展提供公共服务支持上;限制政府部门权力,赋予行业组织、受众组织、中介组织在完善动漫市场交易、动漫产品开发和动漫市场监管方面发挥作用的空间;从市场本位出发,调整产业政策中削弱市场主导性的要素,从激励动漫企业竞争、维护动漫市场公平竞争秩序、培育动漫消费市场等方面增强动漫市场内生动力。

摘要：本文对高职院校艺术设计专业学科教学在美育重塑工作中的作用进行了分析,阐述了艺术设计专业学科教学对美育重塑工作的基础价值、推动价值以及融合价值,提出应重点解决艺术设计专业学科教学与美育的融合问题,同时扩展到其他院系、专业,更好地促进高职院校美育工作的开展、美育水平的持续提升,从而形成多样化、高质量的新型美育体系。