摘要：A novel decentralized indirect adaptive output feedback fuzzy controller is developed for a class of large-scale uncertain nonlinear systems using error *** the properly filtering of the observation error dynamics,the strictly positive-real condition is guaranteed to hold such that the proposed output feedback and adaptation mechanisms are practicable in practice owing to the fact that its implementation does not require the observation error vector itself any more,which corrects the impracticable schemes in the previous literature *** presented control algorithm can ensure that all the signals of the closed-loop large-scale system keep uniformly ultimately bounded and that the tracking error converges to zero *** decentralized output feedback fuzzy controller can be applied to address the longitudinal control problem of a string of vehicles within an automated highway system（AHS） and the effectiveness of the design procedure is supported by simulation results.

摘要：Angiokinases, such as vascular endothelial-, fibroblast-and platelet-derived growth factor receptors(VEGFRs, FGFRs and PDGFRs) play crucial roles in tumor angiogenesis. Anti-angiogenesis therapy using multi-angiokinase inhibitor has achieved great success in recent years. In this study, we presented the design, synthesis, target identification, molecular mechanism, pharmacodynamics(PD)and pharmacokinetics(PK) research of a novel triple-angiokinase inhibitor WXFL-152. WXFL-152,identified from a series of 4-oxyquinoline derivatives based on a structureeactivity relationship study,inhibited the proliferation of vascular endothelial cells(ECs) and pericytes by blocking the angiokinase signals VEGF/VEGFR2, FGF/FGFRs and PDGF/PDGFRβ simultaneously in vitro. Significant anticancer effects of WXFL-152 were confirmed in multiple preclinical tumor xenograft models, including a patientderived tumor xenograft(PDX) model. Pharmacokinetic studies of WXFL-152 demonstrated high favourable bioavailability with single-dose and continuous multi-dose by oral administration in rats and *** conclusion, WXFL-152, which is currently in phase Ib clinical trials, is a novel and effective tripleangiokinase inhibitor with clear PD and PK in tumor therapy.

摘要：The rational design and construction of inexpensive and highly active electrocatalysts for hydrogen evolution reaction(HER)is of great importance for water ***,we develop a facile approach for preparation of porous carbon-confined Ru-doped Cu nanoparticles(denoted as Ru-Cu@C)by direct pyrolysis of the Ru-exchanged Cu-BTC metal–organic *** served as the electrocatalyst for HER,strikingly,the obtained Ru-Cu@C catalyst exhibits an ultralow overpotential(only 20 mV at 10 mA cm^(-2))with a small Tafel slope of 37 m V dec^(-1)in alkaline *** excellent performance is comparable or even superior to that of commercial Pt/C *** functional theory(DFT)calculations confirm that introducing Ru atoms into Cu nanocrystals can significantly alter the desorption of H_(2) to achieve a close-to-zero hydrogen adsorption energy and thereby boost the HER *** strategy gives a fresh impetus to explore low-cost and high-performance catalysts for HER in alkaline media.

摘要：金属-有机骨架材料(Metal-organic frameworks,MOFs),因其具有较好的热稳定性、化学稳定性、可设计性等特点,广泛应用于气体吸附、物质分离、提纯、催化等领域,同时也作为模板制备各种功能材料.MOFs作为色谱分离的材料已得到了较多的研究与应用.按照被分离物质的类别,综述和总结了不同MOFs材料作为色谱固定相的分离效果,重点介绍了MOFs材料的色谱分离机理.MOFs材料的孔径、功能基团和不饱和金属位点在分离中起到重要的作用,最后对MOFs在色谱分离应用中的问题和前景进行了分析和展望.

摘要：使用有限元软件分析了橡胶衬套对悬架NVH性能的影响。柔化其他悬架部件,建立了多体动力学刚柔耦合模型。通过试验设计(DOE)分析了橡胶衬套刚度对悬架NVH性能的灵敏度并进行了优化。通过对比优化前后仿真结果,可以看出悬架中高频NVH性能得到了改善。将模型仿真与道路模拟机测试结果进行对比,验证了模型的准确性。

摘要：特高频(ultra-high frequency,UHF)传感器的时域输出信号对局部放电宽带检测系统的检测和定位结果具有显著影响,因此评估传感器检测性能时,若能从其时域输出特性出发,将更贴近于宽带检测系统的工程需求。现有的有效高度表征体系不适用于具有非平坦群时延的特高频传感器,在描述传感器时域输出特性时具有局限性。提出了一种基于时域参数的特高频传感器的性能表征方法,通过构造解析脉冲响应函数,从中提取包络峰值、包络宽度和振荡时间三种时域参数,用于描述传感器在局部放电脉冲信号下时域输出波形的峰峰值、上升时间和振荡。设计了有效高度幅频特性与相频特性的测试系统并给出时域参数的测试方法。通过比较两种传感器的时域参数测试结果和实际检测结果对该表征方法进行了检验。研究结果表明:该表征方法能有效地反映UHF传感器的时域输出特性,弥补了现有方法的不足。

摘要：在人们眼里，雕塑家傅中望一向以他的“榫卯结构雕塑”著称于艺坛。“榫卯结构雕塑”就是傅中望，傅中望也就是“榫卯结构雕塑”。二者之间，异质而同构——这自然是一句玩笑话。

摘要：本文系统梳理了刘骁纯在水墨问题思索中最核心的三大理论"骨架"建构,概述了其在水墨艺术批评中将理论架构与实践运用相结合的双重性建构,表明了刘骁纯对中国现当代水墨艺术批评事业的深远影响。

摘要：中国现、当代艺术的一个长期以来都没有解决的突出问题是:一直都在不停地模仿、“翻版”外来的东西,而缺少创造性的“中国版本”艺术,就连冠名和评价系统也都是在照搬外国的一套,却很少见到我们自己的冠名(即便是有,也很难达到一种共识,并形成一种合力,至多是公说公的,婆说婆的),更不用说是建立起自己的价值系统了。这些都是当务之急,都是亟待解决的问题!

摘要：快速断路器可实现短路故障的快速切除,对保证电力系统安全稳定运行具有重要意义。针对一种快速响应、高速运动的新型液压操动机构,建立液压操动机构、传动系统和灭弧室之间的耦合关系,开展液-机-气联合仿真研究,分析不同操作功对动触头运动特性、液压缸缓冲特性和灭弧室反力特性的影响规律,在此基础上,对传动系统应力分布进行计算,对存在破坏风险的零部件提出改进策略,确定试验样机设计方案。研究结果表明:操作功对分闸速度影响明显,确定机构活塞杆侧作用面积为3160mm^(2),分闸速度提升至13.63m/s,触头机械分离时间缩短至4.45 ms,满足快速开断需求。随着机构操作功的提升,机构缓冲力峰值和灭弧室压气反力峰值提升明显,造成部分传动件应力值超标,通过优化液压操动机构缓冲性能以及传动件结构,设计出满足机械强度要求的传动系统。研究成果指导研发了操动机构试验样机,试验结果满足快速开断要求。