摘要：In this paper, we propose and construct an observer design based on a Self-Recurrent Consequent-Part Fuzzy Wavelet Neural Network（SRCPFWNN） for a class of nonlinear system. We use a Self-Recurrent Wavelet Neural Network（SRWNN） to construct a self-recurrent consequent part for each rule of the Takagi-Sugeno-Kang（TSK） model in the SRCPFWNN and analyze the structure of the fuzzy wavelet neural network model. Based on the Direct Adaptive Control Theory（DACT） and a back propagation-based learning algorithm, all parameters of the consequent parts are updated online in the SRCPFWNN. On this basis, we propose a design method using an adaptive state observer based on an SRCPFWNN for nonlinear systems. Using the Lyapunov function, we then prove the stability of this observer design method. Our simulation results confirm that the observer can accurately and quickly estimate the state values of the system.

摘要：In this paper, we propose the Hyper Basis Function （HBF） neural network on the basis of Radial Basis Function （RBF） neural network. Compared with RBF, HBF neural networks have a more generalized ability with different activation functions. A decision tree algorithm is used to determine the network center. Subsequently, we design an adaptive observer based on HBF neural networks and propose a fault detection and diagnosis method based on the observer for the nonlinear modeling ability of the neural network. Finally, we apply this method to nonlinear systems. The sensitivity and stability of the observer for the failure of the nonlinear systems are proved by simulation, which is beneficial for real-time online fault detection and diagnosis.

摘要：Cyclic dinucleotides(CDNs) are known to activate stimulator of interferon genes(STING) and induce type I interferon responses, therefor possess great potentials to be of immunotherapeutic value for cancers and infectious diseases. However, the existence of different single nucleotide polymorphism(SNP) of human STING(hSTING) gene poses an obstacle to achieve broad-spectrum activation by CDNs. We reported here the design and synthesis of a total of 36 CDNs, representing all structural variations, that contain four bases(A, G, C, U) and two linkage directions(2′-5′-linked and 3′-5′-linked phosphodiester).Through systematic evaluation of IFN-β induction with a dual-luciferase reporter assay, we discovered that wild type hSTING and two isoforms(HAQ and AQ) showed strong response while hSTING-R232 H and R293 Q exhibited the relatively weak response to CDNs stimulation. For the first time, we found that the c[G(2′,5′)U(2′,5′)] showed excellent activity against all five hSTING variants even equivalent to the endogenous ligand c[G(2′,5′)A(3′,5′)]. Furthermore, we have also demonstrated that 3′-3′CDNs with two 3′-5′ phosphodiesters showed higher serum and hydrolase stability than 2′-2′ CDNs with two 2′-5′ phosphodiesters and 2′-3′ CDNs with one 2′-5′ and one 3′-5′ phosphodiester. It is very interesting to note that 2′-2′ CDNs has been found for the first time to show strong activity. These findings will stimulate our exploration for the new functional role of CDNs, and provide guidelines to design CDNs based hSTING targeted drugs.

摘要：一、早期中西方传统美学视觉语言学习。温馨(以下简称温):您1981年考入西安美术学院附中,1987年考入北京电影学院美术系,1991年毕业后分配到八一电影制片厂担任美术设计师,工作20年后调回北京电影学院美术学院任教至今,从影33年,参与了三十多部电影、八部电视剧的美术指导工作,从改革开放初期一直到现在,见证了中国电影的发展。很荣幸采访您,今天围绕的主题是您电影美术创作中东方美学思想形成和发展。首先,我想从您的中西方传统美学视觉语言开始说起。您出生在陕北,然后考入西安美术学院附中学习绘画,再进一步考入北京电影学院美术系正式开始您的电影美术设计职业生涯,能说说您的学习绘画经历吗?

摘要：With the continuous development of the electrification industry,the development of high-specific batteries has attracted much ***,the safety of lithiumion batteries is currently unable to meet the market demand due to poor thermal *** the thermal issues is crucial to improve battery *** carbonate(EC)not only plays an important interfacial film-forming role,but also poses safety risks in terms of *** this work,we conducted a series of gradient experiments utilizing different EC amounts and verified the effect of reducing EC on battery performance.A strategy is also proposed to design a new *** methyl carbonate(EMC)is used instead of EC as the main solvent to improve the thermal safety of the battery,while salts and additives are used to dominate the film formation to improve the cycling stability of the battery under high voltages(4.5 V,~90%after 200 cycles).This work paves a new avenue for the development of novel electrolyte systems.

摘要：[PO_(4)]3-possesses small microscopic secondorder susceptibility and polarizability anisotropy,which inherently result in weak second-harmonic generation (SHG)and small ***,a new noncentrosymmetric phosphate,[C(NH_(2))3]3PO_(4)·2H_(2)O,was successfully designed and synthesized by a solution evaporation method.[C(NH_(2))3]3PO_(4)·2H_(2)O without metal ions is composed of planar conjugated guanidine cations and PO_(4)tetrahedrons,which are connected by hydrogen bonds,forming a three-dimensional *** property measurements indicate that the title compound displays an SHG response of 1.5×KH_(2)PO_(4)(KDP) and a larger birefringence (0.055@546.1 nm)compared with most reported ultraviolet nonlinear optical ***,first-principles calculations reveal that theπ-conjugated planar[C(NH_(2))3]+cations and[PO_(4)]3-groups are responsible for its excellent linear and NLOproperties.

摘要：屋顶是建筑视觉造型和功能开发的重要元素之一,也是地域文脉与现代化程度的重要体现,依据产生的历史背景可以分为传统屋顶、现代屋顶和后现代屋顶,每个地域在特定阶段都拥有自己相应的屋顶艺术典范。时下,建筑旅行蔚然成风,特色建筑正日益成为衡量现代城市景观优劣的标准。作为建筑的"点睛之笔",屋顶于其中的作用自不可小觑。本文即从介绍屋顶入手,分析其与地域特色塑造之间的关系,以期为创建魅力城市提供一己之见。

摘要：魏晋诗学自觉的标志主要体现在"诗缘情"思潮。从理论新变来看,人们对诗赋具有审美愉悦的抒情性质的认识逐步深化,以致触及到诗歌艺术的本质特点;从诗赋创作而言,语言艺术的特点随着文学与音乐的分离而突现出来,从标题到内容都发生了变化。

摘要：加快发展新质生产力背景下,数字文化产业日益成为新时代促进文明交流互鉴的重要媒介,助力推动中国文化传播与人类命运共同体建设。2023年,数字文化产业“出海”取得新突破,影视剧、游戏、短视频、动漫进一步助力扩大中国文化影响力。然而,产业发展也面临海外竞争压力增大等挑战,需从政策、产业、社会层面合力夯实根基。

摘要：为满足导向钻井中不用起钻变更钻具组合，就能快速钻出高质量的井眼轨迹的客观要求，提出了一种由单片机控制调频调压的供电模块设计方案。该方案与现阶段钻井导向系统中常用的由可调元器件构成的三端稳压电源所实现的供电模块、以及利用IGBT绝缘栅双极型晶体管的双向导电功能实现的供电模块不同在于，它采用单片机AT89C5控制调频调压主电路，结合桥式逆变电路，通过IR2110驱动实现调频，并设计过电流（压）保护。测试结果表明，依据该方案所实现的供电模块设计原理简单、控制可靠、成本低廉，能满足钻井导向系统在各类工况下供电模块应用要求。