摘要：In an attempt to develop potent antitumor agents,new rhodacyanine analogues containing the pyridinium ring（5a-5h）,the isoquinolinium ring（6a-6c） and the quinolinium ring（7a-7e） linked to the rhodanine ring via N-N covalent bond were designed, synthesized and evaluated for antitumor activity against human lung cancer cell line（H460） by MTT assay in *** of the tested compounds showed enhanced antitumor activity with IC_（50） values ranging from 0.006 to 9.2 u,mol/L as compared to the lead compound *** them,the most promising compound 7d（IC_（50） = 0.006μmol/L） was 216.7 times more active than MKT-077（IC_（50） = 1.3μmol/L）.The preliminary structure-activity relationship of the target compounds was discussed.

摘要：A novel series of 5H-pyridazino[4,5-b]indoles were designed and synthesized in order to find novel potent anticancer compounds. The structures were confirmed by ^1H NMR and MS. Their antiproliferative activities against two cancer cell lines were tested by the MTT method in vitro. Three of compounds （1e, 1g, and 1h） exhibited potent antiproliferative activities, especially compound lh （with IC50 values of 5.2 μmol/L and 1.9 μmol/L against Bel-7402 and HT-1080, respectively）. The preliminary structure-activity relationships of 5H-pyridazino[4,5-b]indole derivatives were discussed.

摘要：In our efforts to identify novel potent anticancer agents, we synthesized a series of 2,7-disubstituted triazolo[1,5-a]pyrimidines （6-16）. Their antiproliferative activity against Bel-7402, HT- 1080 and WI-38 cell lines was tested by MTT assay in vitro. Four of the compounds （9-11 and 16） displayed promising antiproliferative activity superior to gefitinib, especially compound 9. A preliminary SAR study of these derivatives was performed.

摘要：A new series of diaryl urea derivatives bearing N-acylhydrazone moiety were designed and synthesized. All the target compounds were evaluated for their antiproliferative activities against human leukemia cell line （HL-60）, human lung adenocarcinoma epithelial cell line （A549） and human breast cancer cell line （MDA-MB-231） in vitro by standard MTT assay. The pharmacological results indicated that some compounds exhibited promising antitumor activities. Compound 1j showed the most potent antiproliferative activity against the tested three cell lines with IC50 values of 0.13 μmol/L, 0.7 μmol/L and 0.5μmol/L, respectively.

摘要：席勒将悲剧与崇高联系起来,认为二者体现了理性和道德对感性和自然的胜利。黑格尔将悲剧定义为伦理实体的辩证运动,对立的伦理力量的辩证和解被视为悲剧的艺术效果。两者的悲剧观,都以自由的实现为根本目的。只不过在席勒的悲剧理论中,自由体现为康德式的道德自律的胜利,具有理想主义的超越性;而在黑格尔的悲剧理论中,自由意味着伦理实体在悲剧中一个辩证周期的完成,具有现实主义的深刻性。

摘要：针对基于单级朗肯循环的液氮发动机效率低和主换热器外表面结霜的问题,设计了基于等熵膨胀的液氮-甲烷-乙烯-R134a四级朗肯循环液氮发动机动力系统新方案.计算结果表明,液氮在所设计的热力循环下的比输出功比采用单级朗肯循环提高了129%;即便充分考虑不可逆因素的影响,液氮的比输出功也远大于蓄电池的比输出功.由于新系统中最上一级热力循环的温度超过水的冰点,避免了主换热器的结霜问题,同时将太阳热能引入新系统,进一步提高了动力系统的效率.比较了基于新循环与基于二级布莱顿循环的液氮动力系统,指出在理想情况下两者的比输出功接近,但当考虑压降和温差等实际因素时,二级布莱顿循环的比输出功远小于所设计的多级多组分朗肯循环.

摘要：介绍了飞机翼梁损伤试验,针对试验中蒙皮孔边早期出现疑似可检裂纹可能导致试验无法正常进行的情况,提出了拆除裂纹孔边铆钉的方法达到延缓裂纹扩展的目的。通过有限元分析软件,建立含裂纹结构应力强度计算模型,研究了拆除铆钉法在飞机整体翼梁损伤容限试验中的具体应用,通过静强度理论及断裂力学理论分析,对蒙皮孔边铆钉孔的受力状态、临界裂纹长度、疲劳寿命进行计算,指出拆除铆钉法本质是通过疲劳危险部位的逐渐转移来延长结构的疲劳寿命。给出的理论分析方法,可供飞机结构设计及修理参考。

摘要：建立车用发动机润滑性能试验系统,测量润滑系统在加速过程中的动态流量、压力和质量含气率等参数随转速增加的变化过程,评价发动机加速过程中润滑安全裕量.结果表明:在加速过程中润滑压力响应速度最快,流量次之,质量含气率响应迟滞时间最长;随着润滑油温度降低和角加速度增加,润滑流量响应迟滞时间明显延长,泄压阀开启和流量滞后引起的液压功率损失增加,润滑油质量含气率峰值增大,最低润滑安全裕量呈现对数的下降趋势.在低于60℃条件下,加速过程中润滑油质量含气率峰值超过设计要求的上限.

摘要：钢琴作为乐器之王,其可以为人声,或是对任何一种乐器进行伴奏,尤其钢琴伴奏在声乐表现中承担了渲染及补充音乐情绪的重要作用。本文首先简述了钢琴伴奏在声乐表演艺术中的地位,进而对钢琴伴奏在声乐表演艺术中的作用进行了探讨,最后总结了在钢琴伴奏与声乐的完美配合上需要注意的几个方面。

摘要：介绍了组合翼梁和整体翼梁结构的区别,利用ANSYS软件对整体翼梁损伤容限特性进行分析,讨论了有止裂筋条和无止裂筋条两种情况下的损伤容限特性,研究了止裂筋条在不同结构参数面积下的应力强度因子变化规律。根据静强度理论、断裂力学准则及检查间隔要求,结合整体翼梁结构参数及其传力特点,在止裂筋条面积赋初值的基础上,从止裂筋条面积能否同时满足静强度理论、断裂韧性准则及检查间隔要求角度,采用计算迭代给出了飞机整体翼梁止裂筋条结构参数确定方法。为今后飞机整体翼梁结构损伤容限设计提供了参考依据。