摘要：The effect of dynamic recrystallization(DRX)on the microstructure and mechanical properties of 6063 aluminum alloy profile during porthole die extrusion was studied through experiment and *** grain morphology was observed by means of electron backscatter diffraction(EBSD)*** results show that,at low ram speeds,increasing the ram speed caused an increase in DRX fraction due to the increase of temperature and strain *** contrast,at high ram speeds,further increasing ram speed had much less effect on the temperature,and the DRX faction decreased due to high stain *** microhardness and fraction of low angle boundaries in the welding zones were lower than those in the matrix *** grain size in the welding zone was smaller than that in the matrix zone due to lower DRX *** decrease of grain size and increase of extrudate temperature were beneficial to the improvement of microhardness.

摘要：While offering a entire class of students the course of basic medicine experimental design,the teacher is required to guide simultaneously multiple research groups of them at a limited period of time in conducting independently design of interdisciplinary experimental research,selecting and revising the optimal designs,putting these projects into *** this teaching process,the course is expected to improve students’ability to carry out scientific research and *** is apparently difficult for an assigned teacher who has been engaged in a certain discipline to be responsible for the whole teaching process and to achieve the teaching goal of this *** fact,whether the curriculum can be run effectively is not only dependent on the active participation of teachers and students,but also the overall and firm support from university’s *** spite of that,the teacher’s role in the curriculum is still *** the present report,the pathophysiology discipline was responsible for the work of both interdisciplinary teaching team construction and the curriculum *** team included the multiple disciplinary teachers of basic medical science,the specialist teachers of scientific research methodology such as medical statistics,medical literature retrieval,laboratory animal science and senior *** is favorable for this form to successfully conduct the curriculum of basic medicine experimental design by making full advantages of this multiple disciplinary *** significance of the teaching team construction,its tasks,the manner of teaching quality assessment and the operational mechanism are described in this *** is believed to be a new form of teachers’team construction of higher medical schools.

摘要：Thanks to the fast improvement of the computing power and the rapid development of the computational chemistry and biology,the computer-aided drug design techniques have been successfully applied in almost every stage of the drug discovery and development pipeline to speed up the process of research and reduce the cost and risk related to preclinical and clinical *** to the development of machine learning theory and the accumulation of pharmacological data, the artificial intelligence(AI) technology, as a powerful data mining tool, has cut a figure in various fields of the drug design, such as virtual screening,activity scoring, quantitative structure-activity relationship(QSAR) analysis, de novo drug design, and in silico evaluation of absorption, distribution, metabolism, excretion and toxicity(ADME/T) properties. Although it is still challenging to provide a physical explanation of the AI-based models, it indeed has been acting as a great power to help manipulating the drug discovery through the versatile frameworks. Recently, due to the strong generalization ability and powerful feature extraction capability,deep learning methods have been employed in predicting the molecular properties as well as generating the desired molecules,which will further promote the application of AI technologies in the field of drug design.

摘要：The construction of high color purity and high resolution organic light-emitting diodes(OLEDs)is facilitated by the development of highly-efficient organic luminescent materials with narrow-band ***,in order to address the problem of broad emission spectra of organic luminescent materials,an effective molecular design strategy is presented to reduce the full width at half maximum(FWHM)of emission by integrating the steric hindrance effect in the pyrene *** the bulky group was introduced into the 2-position,compounds 5 not only show a relative high quantum yield(>0.31)in the solid state,but also can suppress the molecular rotation of triphenylamine(TPA)at the 3-position to narrow the FWHM in the solid state compared to that in *** 5c containing biphenyl units exhibits a maximum emission peak at 484 nm with a quantum yield of 0.38 and FWHM value of 49 nm in the solid state.

摘要：Image denoising is a fundamental and important task in image processing and computer vision fields. A lot of methods are proposed to reconstruct clean images from their noisy versions. These methods differ in both methodology and performance. On one hand, denoising methods can be classified into local and nonlocal methods. On the other hand, they can be marked as spatial and frequency domain methods. Sparse coding and low-rank are two popular techniques for denoising recently. This paper summarizes existing techniques and provides several promising directions for further studying in the future.

摘要：目的探究抑郁症(major depressive disorder,MDD)患者脑灰质容积与身体质量指数(body mass index,BMI)的差异化关联现象。方法该研究共纳入113名抑郁症患者及107名健康志愿者,对其采集脑高分辨率T1WI图像,使用SPM12软件处理并计算脑灰质容积,运用SPM的Flexible factorial设计,探究“抑郁×BMI”两个因素对脑灰质容积的交互效应,后进一步探究抑郁症患者灰质容积动态变化与BMI的相关性。结果“抑郁×BMI”两个因素的交互效应显著的脑区包括右侧岛叶、后扣带回、右侧额中回、右侧额上回(独立体素阈值P<0.01,AlphaSim矫正,矫正阈值P<0.05)。另外,随访中脑灰质容积减少的程度,仅右侧岛叶与BMI的相关存在显著性(P<0.05)。结论较健康人,抑郁症个体中脑灰质容积与BMI存在差异化关联现象,且灰质容积的动态减低可能依赖于BMI,证实了抑郁症个体中BMI与疾病相互依赖并对脑灰质容积存在共同作用。

摘要：Bending deformation behaviors of solution treated(ST),natural aged(NA)and T6tempered6063aluminum alloy sheetswere studied by three-point bending *** changes of bending force,interior angle,bending radius and sheet thickness in thefillet region were analyzed by experimental measurements and numerical *** results showed that the bendingcharacteristics were strongly dependent on the heat treatment *** T6alloy sheets were bent more sharply and localplastic deformation occurred severely in the fillet ***,the ST and NA alloy sheets exhibited relatively uniform bendingdeformation and large bending *** bending force of T6alloy was the highest,followed by the NA alloy and that of the STalloy was *** unloading,as compared with the ST and NA alloys,the springback of T6alloys was markedly *** time showed a positive sensitivity on the springback and non-uniform bending *** bending characteristics areattributed to the combined effects of yield strength,yield ratio and coefficient of neutral layer.

摘要：The interfacial heat transfer coefficient between hot profile surface and cooling water was determined by using inverse heat conduction model combined with end quenching experiment. Then, a Deform-3 D thermo-mechanical coupling model for simulating the on-line water quenching of extruded profile with unequal and large thicknesses was developed. The temperature field, residual stress field and distortion of profile during quenching were investigated systematically. The results show that heat transfer coefficient increases as water flow rate increases. The peak heat transfer coefficient with higher water flow rates appears at lower interface temperatures. The temperature distribution across the cross-section of profile during quenching is severe nonuniform and the maximum temperature difference is 300 ℃ at quenching time of 3.49 s. The temperature difference through the thickness of different parts of profile first increases sharply to a maximum value, and then gradually decreases. The temperature gradient increases obviously with the increase of thickness of parts. After quenching, there exist large residual stresses on the inner side of joints of profile and the two ends of part with thickness of 10 mm. The profile presents a twisting-type distortion across the cross-section under non-uniform cooling and the maximum twisting angle during quenching is 2.78°.

摘要：局域共振带隙和Bragg带隙可同时存在于超材料梁中,利用两种带隙之间的相互耦合效应可以实现超宽耦合带隙设计,在宽带减振领域极具应用潜力.以往研究通常考虑单振子超材料梁的单阶耦合带隙设计,因而只能实现单阶的超宽耦合带隙,无法满足双目标或多目标频带的宽带减振需求.为此,本文开展了双振子超材料梁的双阶耦合带隙调控设计研究,提出了一种实现双阶耦合宽带隙的设计方法,分析了所设计双阶耦合带隙相比传统单阶耦合带隙的带宽优势,并探究了双振子质量分配比对双阶耦合带隙总宽度的影响,进一步设计出最优的质量分配比,使得实现的双阶耦合带隙的总宽度最宽.此外,还采用谱元法研究了基于双阶耦合带隙设计的双振子超材料梁的减振特性,通过与有限元法进行对比,验证了谱元法的准确性,研究表明基于双阶耦合带隙设计可以实现两个宽频带范围的高效减振.

摘要：为提高产品设计中产生新创意和新方案的效率及对方案进行评价择优的决策科学性,对融合可拓学与TRIZ的产品设计创意生成方法进行了细化。先利用基元理论建立可拓模型,获得产品创新的出发点,再通过TRIZ理论的技术参数、发明原理和可拓学的拓展分析与可拓变换方法进行交叉分析,获得产品具体创意。最后对所获得的产品创意利用优度评价方法进行评价优选,选出符合需求的创意,并形成产品创新设计方案。以手机充电器为例,利用该方法得到了多种设计创意,验证了细化方法的有效性。