摘要：Cancer is the most common cause of human mortality and has created an unbridgeable health gap due to its unrestrained aberrant proliferation,rapid growth,metastasis,and high *** two-dimensional cell culture and animal models for tumor diagnostic and therapeutic studies have extremely low clinical translation rates due to their intrinsic *** tumor models are therefore required for cancer *** human three-dimensional(3D)cancer models stand out for their ability to better replicate the spatial organization,cellular resources,and microenvironmental features(e.g.,hypoxia,necrosis,and delayed proliferation)of actual human ***,the fabrication of these models can be achieved by an emerging technology known as 3D bioprinting,which allows for the fabrication of living structures by precisely regulating the spatial distribution of cells,biomolecules,and matrix *** aim of this paper is to review the current technologies and bioinks associated with 3D bioprinted cancer models for glioma,breast,liver,intestinal,cervical,ovarian,and neuroblastoma,as well as,advances in the applications of 3D bioprinted-based tumor models in the fields of tumor microenvironment,tumor vascularization,tumor stem cells,tumor resistance and therapeutic drug screening,tumorimmunotherapy,and precision medicine.

摘要：本文以便携式小型旋耕机蜗杆减速器的设计方法为基础,使用Pro/ENGINEER的二次开发软件包Pro/TOOLKIT开发了蜗杆的程序化设计系统。该设计系统界面简单、直观,操作方便,降低了设计者的工作量,缩短了蜗杆蜗轮齿廓曲线绘制的设计周期,并易于进行蜗杆传动的运动仿真及蜗杆减速器的运动分析。

摘要：刀具架是履带式绿篱机的重要组成部分,为克服传统刀具架在调节刀具高度时无法保证修剪质量的缺点,设计一种新型刀具架结构,以实现刀具高度调节的同时保证修剪质量。运用MATLAB完成了刀具架结构的受力分析与计算,依据计算结果设计刀具架结构,在SolidWorks建模软件中完成刀具架建模。最后运用ANSYS Workbench对刀具架装配体进行有限元分析,完成对刀具架结构强度和刚度的校核。结果表明刀具架结构设计合理,满足实际应用要求。

摘要：随着城镇化进程的加快,城市配电网可靠性、智能化和数字化水平的提高也变得越来越迫切.为确保城市运行安全和经济社会平稳发展,在过电压在线监控系统软件设计的基础上进行了硬件改进,使过电压在线监控系统的可行性和必要性通过现场安装试验得到完整验证.

摘要：[目的]基于荧光定量免疫层析技术,开发一种全量程C-反应蛋白(C reactive protein,CRP)定量检测试剂盒。[方法]采用双抗体夹心法,检测人血中的CRP浓度水平。[结果]该方法的灵敏度为0.1 mg/L,线性范围为0.0～150 mg/L,批内变异系数为8.94%～13.39%,批间变异系数为10.0%～16.8%,相对偏差小于10%,40例临床标本的测试结果显示该试剂与国外试剂的测定结果具有良好的相关性,相关系数r>0.97.具有良好的相关性。[结论]建立一种操作简便,灵敏度高,有良好准确性和重复性,线性范围较宽,满足临床检验需求的全量程C-反应蛋白检测试剂盒。