摘要：In order to enhance the targeted delivery of anticancer drugs by polymeric micelles, folic acid(FA), the ligand of folate receptor(FR) over-expressed in the most cancer cells, modified p H-sensitive polymeric micelles were designed and fabricated to encapsulate doxorubicin(DOX) by combination of p H-sensitive amphiphilic polymer poly(2-ethyl-2-oxazoline)-poly(D,L-lactide) with FA-conjugated poly(2-ethyl-2-oxazoline)-poly(D,L-lactide). The prepared micelles were characterized to have about 36 nm in diameter with narrow distribution, well-defined spherical shape observed under TEM and p H-responsive drug release behavior. Moreover, the tumor targeting ability of the FA-modified p H-sensitive polymeric micelles was demonstrated by the cellular uptake, in vitro cytotoxicity to FR-positive KB cells and in vivo real time near-infrared fluorescence imaging in KB tumor-bearing nude mice. The efficient drug delivery by the micelles was ascribed to the synergistic effects of FR-mediated targeting and p H-triggered drug release. In conclusion, the designed FR-targeted p H-sensitive polymeric micelles might be of great potential in tumor targeted delivery of water-insoluble anticancer drugs.

摘要：Oral administration is the best way for the most patients due to the good compliance,and intestinal epithelium is the main barrier of oral drug *** order to overcome the small intestine epithelial barrier to orally deliver water-insoluble drugs,deoxycholic acid(DA),a substrate of the intestinal bile acid transporters,conjugated poly(2-ethyl-2-oxazoline)-poly(D,L-lactide)(DA-PEOz-PLA)was designed and synthesized,and deoxycholic acid-modified polymeric micelles composed of DA-PEOz-PLA and mPEG-PLA were fabricated to encapsulate model drug coumarin 6(C6)based on intestinal bile acid *** structure of DA-PEOz-PLA was confirmed using 1 H NMR and TLC,and the molecular weight measured by GPC was 10034 g/mol with a PDI of *** C6-loaded polymeric micelles with drug loading content of 0.085%were characterized to have 40.11 nm in diameter and uniform spherical morphology observed by ***,the deoxycholic acid-modified polymeric micelles were demonstrated to further enhance the transmembrane transport *** mechanic study evidenced that anchorage of deoxycholic acid onto the micelles surface enriched their transcellular transport ***,the designed deoxycholic acid-modified polymeric micelles might have a promising potential for oral delivery of water-insoluble drugs.

摘要：To overcome the main barrier of intestinal epithelium for the oral absorption of poorly water-soluble drugs and further improve their oral absorption, Gly-Sar, the substrate of the oligopeptide transporter PepT1 widely distributed in the small intestine,conjugated poly(ethylene glycol)-block-poly(D,L-lactide)(Gly-Sar-PEG-b-PLA) was designed and synthesized, and Pep T1-targeted polymeric micelles were prepared and characterized. The structure of the synthesized Gly-Sar-PEG-b-PLA was confirmed by use of TLC and 1 H-NMR. The average molecular weight measured by GPC was 5954 g/mol with PDI of 1.34. The DiI-loaded polymeric micelles from Gly-Sar-PEG-b-PLA with drug loading content of 0.076% were characterized to exhibit 40.36 nm in diameter with PDI of 0.294, and well-defined spherical shape observed by TEM. Furthermore, the PepT1-targeted polymeric micelles profoundly enhanced intestinal absorption of poorly water-soluble drug. Therefore, the designed PepT1-targeted polymeric micelles might have a promising potential for oral delivery of water-insoluble drugs.

摘要：设计了与压铸自动化生产相适应的连杆型脱模剂喷涂机械手,并对该机械手的相关结构参数进行了优化处理和选择。所设计的连杆型喷涂机械手可以实现对不同模具型面形状和模具厚度、不同铸件大小和厚度的模具进行脱模剂喷涂。应用线性加权法,采用Mathematic软件,通过调整取得了喷涂机构的结构优化参数,并利用自身编制的软件进行了验证。该机械手可以广泛地应用于自动压铸喷涂,稳定和提高喷涂质量。

摘要：采用拉伸实验,硬度测试,微观组织OM及SEM(+EDS)分析,XRD,DSC等方法,研究了微量钇(质量分数分别为0.025%、0.05%、0.075%、0.1%)以及T6处理对铸造Al-7Si-0.3Mg合金的组织性能及其共晶转变温度的影响。结果表明,钇微合金化后的Al-7Si-0.3Mg合金的屈服强度(YS)、抗拉强度(UTS)和延伸率(El)均有所提高,以0.05%Y含量的综合性能最佳。结合微观组织分析表明,强化相主要为Si相和Mg_(2)Si相,且Mg_(2)Si往往伴随着Si相存在。微含量的钇使α_(Al)+β_(Si)→Liquid反应温度下降(分别下降1.1、2.0、1.4、2.2℃),且使α_(Al)→Liquid反应温度有所提高;适量的钇促进α-Al异质形核基底的形成,且与β_(Si)和Mg_(2)Si等形成多元相,提高凝固时的过冷度。

摘要：在分析了图书馆资源服务现状的基础上,介绍了电子杂志2.0的相关概念,阐述了电子杂志2.0与个性化推荐服务的关系,提出了利用电子杂志实现图书馆文献推送服务的思路,设计了电子杂志实现图书馆文献服务的应用模型,对主要的电子杂志主题做了介绍,探讨了面临的问题及对策。初步的实践表明:此种服务方式是可行的。

摘要：针对现有k-匿名隐私保护方法的缺点,提出了3种基于敏感元组的隐私数据发布方法.首先,通过定义敏感元组,设计了只保护隐私信息的朴素敏感元组匿名方法(NSTAM).然后,在引入敏感元组密度的基础上,提出了一种扩展的敏感元组保护方法(e-STAM);该方法通过对敏感元组进行mk-匿名运算,引入(1-m)k个非敏感元组,并同等概化引入的非敏感元组,使得匿名后每个分组中的敏感元组密度满足用户设定的阈值m.最后,针对实际应用中发布数据的敏感度差异,引入了加权敏感元组密度概念,并设计了加权的敏感元组数据保护方法(WSTAM);该方法通过对敏感值和敏感元组赋予不同的权重,实现对敏感元组的区别保护.理论分析和实验结果表明,这3种算法能够提高发布数据的精度,保证敏感数据的安全度,因此是有效可行的.

摘要：设计了一种应用于压力铸造脱模剂喷涂的直立型机械手,并就现行压铸机规格初步对该机械手进行了系列化。该机械手的主要组成部分为雾化器、喷管组、纵向进给机构、直角旋转机构等;直角旋转机构主要由带齿条能来回运动的活塞和带机械手进给机构机座的齿轮组成,并通过液压油的驱动使机械手旋转。

摘要：在分析现有图书馆信息系统建设模式的基础上,提出基于软件即服务思想的图书馆信息系统建设思路。介绍软件即服务的定义、特征和成熟度模型,重点阐述基于多租户模型的图书馆信息系统的数据库设计、多租户应用设计、可配置性设计和可伸缩性设计。对多租户信息系统实现中涉及的文件分布式存储、应用服务器的可伸缩性、数据库服务器的可伸缩性以及应用安全等关键技术作深入的讨论。

摘要：在廉政文化建设日益得到高层领导的高度重视与社会各界的广泛认同的今天,利用Internet的巨大功能,开发、建设一个以"廉政文化研究"为主题的特色数据库,十分有利于为廉政文化的研究以及学习、宣传、教育、建设等活动提供高效、系统、直观、优质的服务,推动廉政文化建设向纵深发展。