摘要：The intestinal epithelium is the main barrier to the oral delivery of poorly water-soluble drugs. Based on the specific transporters expressed on the apical membrane of the intestinal epithelium, novel polymer micelles targeting to the organic cation transporter 2（OCTN2） were constructed by combining carnitine conjugated poly（2-ethyl-2-oxazoline）-poly（D,L-lactide）（Car-PEOz-PLA） with monomethoxy poly（ethylene glycol）-poly（D,L-lactide）（mP EG-PLA）. The structure of the synthesized Car-PEOz-PLA was confirmed by -1H NMR, TLC and ammonium reineckate precipitation reaction, and the number-average molecular weight determined by GPC was 7260 g/mol with a low PDI of 1.44. Coumarin 6-loaded carnitine modified polymeric micelles prepared by film hydration method were characterized to have a nano-scaled size of about 31 nm in diameter, uniform spherical morphology, high drug loading content of 0.098%±0.03% and encapsulation efficiency of 92.67%±2.80%. Moreover, the carnitine-modified micelles exhibited the similar in vitro release behavior in SGF and SIF, and evidently enhanced intestinal absorption of poorly water-soluble agent. Therefore, the designed OCTN2-targeted micelles might have a promising potential for oral delivery of poorly water-soluble drugs.

摘要：In the present study, we designed and fabricated pH-sensitive polymeric micelles based on the conjugate of poly（2-ethyl-2-oxazoline）-poly（D,L-lactide）（PEOz-PLA） with doxorubicin（PEOz-PLA-imi-DOX） to efficiently inhibit tumor cell growth. Hence, PEOz-PLA-imi-DOX was successfully synthesized by connecting DOX to the hydrophobic end of pH-sensitive PEOz-PLA via acid cleavable benzoic imine linker and characterized by 1 H NMR spectrum and thin layer chromatography. The critical micelle concentration of PEOz-PLA-imi-DOX was determined to be（14.84±3.85） mg/L. The conjugate micelles（denoted as PP-DOX-PM） formed by PEOz-PLA-imi-DOX using film-hydration method were characterized to have a nano-scaled size of about 21 nm in diameter, and the drug loading content was 1.67%. PP-DOX-PM showed pH-dependent drug release behavior with gradually accelerated release of DOX with decrease of pH value, illustrating the micelles＇ distinguishing feature of endo/lysosomal pH from physiological pH by accelerating drug release. As anticipated, PP-DOX-PM maintained the cytotoxicity of DOX against MDA-MB-231 cells. Collectively, PP-DOX-PM might have great potential for effective suppression of tumor growth.

摘要：To ensure the delivery of antitumor drugs to tumor site and quick release in tumor cells, we designed and prepared pH-sensitive polymeric micelles by combining cationic ring-opening polymerization of 2-ethyl-2-oxazoline （EOz） with vitamin E succinate （VES）, and then encapsulating paclitaxel （PTX） into the micelles self-assembled by poly（2-ethyl-2-oxazoline）-vitamin E succinate （PEOz-VES）. The structure of the synthesized PEOz-VES was confirmed by ^1H NMR spectrum, and the molecular weight measured by GPC was 1212 g/mol. The pKa of PEOz-VES with a low critical micelle concentration of （5.84±0.02） mg/L was determined to be 6.01. The PTX-loaded PEOz-VES polymeric micelles prepared by film hydration method were characterized to have a nanoscaled size of about 30 nm in diameter, a positive Zeta potential of 4.86 mV and uniform spherical morphology by TEM observation. The drug loading content and encapsulation efficiency were （2.63±0.16）% and （84.1±3.38）%, respectively. The in vitro release behavior of PTX from PEOz-VES micelles in PBS displayed pH-dependent pattern and was gradually accelerated with decrease of pH value, implying that the micelles could distinguish endo/lysosomal pH and tumor extracellular pH from physiological pH by accelerating drug release. Therefore, the designed PEOz-VES micelles might have significant promise for anti-cancer drug delivery.

摘要：表面活性物质的表面张力等温线测定是大学物理化学实验的重要内容。随着磷脂类表面活性剂的广泛应用,有必要在大学化学中更新经典表面张力等温线测定的实验内容,并使学生掌握先进的测量方法。以二硬脂酰基磷脂酰胆碱(DSPC)和二棕榈酰基磷脂酰胆碱(DPPC)为研究对象,应用界面张力仪测定了两种溶液表面张力等温线,计算了其表面超量和分子横截面积,并设计了拓展性实验内容,对于培养学生分析问题和解决问题的能力具有积极的意义。

摘要：产业生态位测评对产业协同发展具有重要的指导意义。文章结合生态位理论,从产业资源生态位、市场环境生态位和产业政策生态位三方面,构建文化创意产业生态位评价指标体系和评价模型。结合2014—2018年面板数据,展开对长三角城市群文化创意产业生态位分布现状和空间关联关系的实证分析。结果表明:长三角城市群文化创意产业资源生态位相似度较高,产业环境生态位差异性较大,产业政策生态位高度相似。同时,长三角城市群生态位空间关联效应明显,各城市之间不存在孤立点,整体上呈现出东强西弱的特点。

摘要：随着国家和上海市政府对文化创意产业的大力扶持,上海市文化创意产业发展水平居中国首位。而区域物流作为连接文化与市场的纽带,与文化创意产业是利益共同体,协同发展是为了获得双赢的结果,一方面,区域物流是文化创意产业的底层支撑,推动文化创意产业优质发展;另一方面,文化创意产业带动区域物流高效发展,推动文化成果转化成高质量的社会资源。基于此,文章通过对上海文化创意产业发展现状与区域物流现状展开研究,探讨二者协同发展的作用机理,初步提出二者协同发展的对策,为其他地域物流产业和文化创意产业的发展提供理论支撑。

摘要：为了提高无人机在恶劣环境下的工作能力,将从遥感系统中采集的视频信号转换为数字信号,设计了基于CPLD系统的FSK调制解调收发电路,用VHDL语言实现了FSK调制解调的设计;同时将CMOS反向器应用于接收电路,构成模拟放大器将信号放大。整个设计基于ALTERA公司的Quartus Ⅱ开发平台,使用MAXⅡ系列的CPLD芯片实现,并用OrCAD PSpice软件对放大电路进行仿真分析。实验结果表明无线收发电路能够保证图像传输质量,达到预期设计的无线传输要求。

摘要：随着经济的发展和人民精神文化需求的提升,文旅融合程度加深。从文旅融合视角探究地域性旅游品牌形象设计,旨在理解文旅融合内涵,把握设计原则,构建科学合理体系,增强文旅融合效果,推动地域性旅游业发展。应当突出地域性旅游品牌特征、展现地域文旅差异、强化创新感。建议运用艺术技能提高设计水平,利用新媒体环境扩大影响范围,为相关研究提供参考.

摘要：户外健身空间的景观环境建设对健康老龄化具有重要意义。本文通过实地问卷调查和实地测量方法探究当下有健身习惯的老年人群的自评健康状况,健身喜好度与行为方式,以及健身景观环境因素的满意度。结果表明,与家人居住的老年人大多健身并感到健康;相对于路程长短,步行等传统交通方式的可达性有利于提高健身喜好度;注重景观审美质量,设计细节关怀,声环境与景观要素和健身活动特点的协同设计可提高健身景观环境的满意度。相关结论可为提高老年人群健身空间景观质量提供参考。

摘要：轨道交通车辆基地用地规划的选址和用地规模对综合开发的可行性和经济性影响显著。通过对车辆基地综合开发的建设周期、建设成本和开发强度分析,发现各个城市的落实程度和效果不一,整体出现综合利用比例低、综合绩效不理想等现象。以北京、南宁等城市为例,对典型车辆基地的规划布局和用地规模进行研究,车辆基地选址普遍位于非生活区,周边缺乏配套基础设施;用地规模受节地模式的影响,导致地块狭长、缺少腹地。研究结果表明在多样化的车辆基地用地程序下,重大项目和单独选址的用地模式导致车辆基地普遍采用节地模式,从而削弱综合利用结构转换层落地的可能性,缺少腹地限制了联合开发与综合平衡的可能性;由于在选址阶段考虑土地收储成本,导致位于城市边缘地区的车辆基地易受地价和周边开发成熟度的制约,影响综合利用率和上盖开发业态。基于此,对车辆基地在功能定位、选址标准、用地程序、规划编制等方面存在的缺失和错位提出改进建议。