摘要：Introduction Despite the numerous breakthroughs made in medical and biomedical technologies,biosensing underneath the skin without any associated pain still sounds like a dream yet to be *** invasive biosensors refer to functional or electronic sensors that can contact the interior environment of living organisms and their biological tissues,while the connected bulk devices remain on the surface of the biological objects[1].Minimally invasive biosensors are currently a key research area because they can not only meet the increasing technical demands to precisely detect biological activities inside biological objects,but also provide an ideal platform to externally incorporate complicated functionalities and electronic integration[2].The current development level of minimally invasive sensing still necessitates solving the constraints and bottlenecks in the three aspects of functionalities,sensitivity and biocompatibility[3].In this perspective,we select minimally invasive sensors as a representative research object with the aim to solve the limitations of current diabetes diagnosis and treatment approaches.

摘要：Modern medicine is increasingly interested in advanced sensors to detect and analyze biochemical *** sensors based on potentiometric methods are a promising platform for monitoring physiological ions in biological *** semi-implantable devices are mainly based on single-parameter *** semi-implantable electrodes for multiparameter sensing have more restrictions on the electrode size due to biocompatibility considerations,but reducing the electrode surface area could potentially limit electrode *** study developed a semi-implantable device system comprising a multiplexed microfilament electrode cluster(MMEC)and a printed circuit board for real-time monitoring of intra-tissue K^(+),Ca^(2+),and Na^(+)*** electrode surface area was less important for the potentiometric sensing mechanism,suggesting the feasibility of using a tiny fiber-like electrode for potentiometric *** MMEC device exhibited a broad linear response(K^(+):2–32 mmol/L;Ca^(2+):0.5–4 mmol/L;Na^(+):10–160 mmol/L),high sensitivity(about 20–45 mV/decade),temporal stability(>2weeks),and good selectivity(>80%)for the above *** vitro detection and in vivo subcutaneous and brain experiment results showed that the MMEC system exhibits good multi-ion monitoring performance in several complex *** work provides a platform for the continuous real-time monitoring of ion fluctuations in different situations and has implications for developing smart sensors to monitor human health.

摘要：随着微纳加工技术和新材料工艺的不断创新,应用于疾病诊断和治疗的电子器件呈现出小型化、柔性化和多功能化的发展趋势.在医学诊断和治疗领域,微创电子器件发挥着越来越重要的作用.微创诊断电子器件提供了靶向引导、手术监控和连续性诊断等功能,为组织病变的原位诊断提供了有效手段.微创治疗电子器件通过个性化调控的方式,为疾病治疗提供了多种选择,显著降低了患者的生理损伤和术后风险,提高了患者的康复速度.本文综述了应用于组织病变微创诊断与治疗的微纳电子器件的类型、特征及其设计思路,并从生化诊疗和物理诊疗技术的角度对其进行技术分析.最后,讨论了目前微纳电子器件在疾病微创诊断和治疗应用中面临的挑战与机遇.

摘要：Conventional blood sampling for glucose detection is prone to cause pain and fails to continuously record glucose fluctuations in *** glucose monitoring based on implantable electrodes could induce pain and potential tissue inflammation,and the presence of reactive oxygen species(ROS)due to inflammationmay affect glucose *** technology is less invasive,yet microneedle adhesion with skin tissue is *** this work,we developed a microarrow sensor array(MASA),which provided enhanced skin surface adhesion and enabled simultaneous detection of glucose and H_(2)O_(2)(representative of ROS)in interstitial fluid in *** microarrows fabricated via laser micromachining were modified with functional coating and integrated into a patch of a three-dimensional(3D)microneedle *** to the arrow tip mechanically interlocking with the tissue,the microarrow array could better adhere to the skin surface after penetration into *** MASA was demonstrated to provide continuous in vivo monitoring of glucose and H_(2)O_(2) concentrations,with the detection of H_(2)O_(2) providing a valuable reference for assessing the inflammation ***,the MASA was integrated into a monitoring system using custom *** work provides a promising tool for the stable and reliable monitoring of blood glucose in diabetic patients.

摘要：为研究蓝莓微波冷冻干燥特性及品质变化,本文探究不同微波功率(300,400,500,600 W)、真空度(50,100,150,200 Pa)和物料装载量(60,120,180,240 g)对蓝莓干燥特性及其品质的影响。在单因素实验基础上进行Box-Behnken中心组合试验设计,以蓝莓的干燥速率、色差、收缩率、复水比、维生素C保存率、花青素保留率的综合评分为评价指标。结果表明:蓝莓在干燥前期的干燥速率较大,且随着微波功率的增加而变大,Page模型的R^(2)均大于0.95,能较好地预测蓝莓干燥过程中的水分变化情况,蓝莓有效水分扩散系数在3.341×10^(-8)~5.110×10^(-8)m^(2)/s之间,且受微波功率和装载量影响显著(P真空度>装载量。当蓝莓干制品的干燥参数为微波功率400 W、真空度100 Pa、装载量120 g时,蓝莓的微波冷冻干燥效果最好,此时蓝莓色泽、复水比、质构特性、VC和花青素含量及内部孔隙分布情况相对最好,品质最佳。

摘要：大气污染特别是气溶胶粒子会对太阳辐射造成影响,在建立辐射模型时应考虑空气污染的影响。通过重庆2017年的实测辐射数据分析,发现空气质量指数(AQI)与太阳日总辐射具有较强的相关性,因此,引入空气质量指数对太阳日总辐射计算模型进行修正,将其与DSRM-C模型对比,并使用2016年的数据验证。结果表明,使用空气污染指数修正的DSRM-A模型的RMSE更小,模拟效果更好。