摘要：Thanks to the fast improvement of the computing power and the rapid development of the computational chemistry and biology,the computer-aided drug design techniques have been successfully applied in almost every stage of the drug discovery and development pipeline to speed up the process of research and reduce the cost and risk related to preclinical and clinical *** to the development of machine learning theory and the accumulation of pharmacological data, the artificial intelligence(AI) technology, as a powerful data mining tool, has cut a figure in various fields of the drug design, such as virtual screening,activity scoring, quantitative structure-activity relationship(QSAR) analysis, de novo drug design, and in silico evaluation of absorption, distribution, metabolism, excretion and toxicity(ADME/T) properties. Although it is still challenging to provide a physical explanation of the AI-based models, it indeed has been acting as a great power to help manipulating the drug discovery through the versatile frameworks. Recently, due to the strong generalization ability and powerful feature extraction capability,deep learning methods have been employed in predicting the molecular properties as well as generating the desired molecules,which will further promote the application of AI technologies in the field of drug design.

摘要：It is an important task to communicate Chinese culture with other countries in the more conflicting global *** Painting School plays a very important part in Chinese art,and it greatly influences the painters of various periods in *** this context,some representative paintings of lijiang Painting School in different periods were collected in this paper as the research *** rewriting theory was applied in the study because Chinese readers and English readers have different cultural backgrounds and diverse *** on the rewriting theory,these representative paintings were translated and the explained in *** the study,it is found that as an intersemiotic translation,the translation of the representative paintings of lijiang Painting School should be focused on those target readers who can’t comprehend directly from the *** addition,the artistic integrity should be considered first before details in ***,the overall perception of target readers gaining from the translations should be paid more attention to rather than *** translation under the guidance of rewriting theory will be helpful for the target readers to understand the connotation of source culture with some cultural images of target readers.

摘要：In order to diagnose the common faults of railway switch control circuit,a fault diagnosis method based on density-based spatial clustering of applications with noise(DBSCAN)and self-organizing feature map(SOM)is ***,the three-phase current curve of the switch machine recorded by the micro-computer monitoring system is dealt with segmentally and then the feature parameters of the three-phase current are calculated according to the action principle of the switch *** to the high dimension of initial features,the DBSCAN algorithm is used to separate the sensitive features of fault diagnosis and construct the diagnostic sensitive feature ***,the particle swarm optimization(PSO)algorithm is used to adjust the weight of SOM network to modify the rules to avoid“dead neurons”.Finally,the PSO-SOM network fault classifier is designed to complete the classification and diagnosis of the samples to be *** experimental results show that this method can judge the fault mode of switch control circuit with less training samples,and the accuracy of fault diagnosis is higher than that of traditional SOM network.

摘要：充分合理地利用竹资源对园林的建设发展具有重要意义。基于Citespace对国内外文献进行可视化分析,发现国内研究对竹类植物观赏性及美学特征的关注度更高,但是在竹类植物园林造景的相关研究中,存在应用方式与竹种特性联系不紧密、造景手法与配置方式内容交叉的问题。因此,探讨了竹类植物在不同造景手法和应用方式下的造景效果,并列举适用竹种,将应用场景的范围拓展至防护绿地、道路绿地等,为竹类植物广泛运用于园林景观提供思路。

摘要：提出一种标定超短脉冲测量装置时间分辨率的新方法。设计制作可产生特定时间延迟的平面平晶,标定时将其放置在自相关仪前的光路中;待测光脉冲经过平面平晶后会产生时间延迟为T的双脉冲,该双脉冲到达自相关晶体发生相互作用,产生自相关信号,此时信号的主峰两端会出现较为明显的次峰信号,该次峰信号之间的时间间隔为2T,这样双脉冲的时间延迟就转换为次峰信号峰值的空间距离,经CCD接收后可计算得到自相关仪的时间分辨率。采用此方法对自相关仪时间分辨率标定的结果为217.88 fs/pixel,与移动光程延迟器法得到的标定结果214.27 fs/pixel相比,相对误差仅为1.68%;与可单次标定的鉴别率板法相比,采用此方法标定结果的相对扩展不确定度为1.50%,优于鉴别率板法的6.96%。

摘要："亲水性"堤岸是能够满足当代人们滨水游憩活动要求的亲切堤岸。它侧重于堤岸的景观效果和人们的使用要求。本文从"亲水性"堤岸的概念、特点入手,对现阶段堤岸存在的问题进行了分析,对"亲水性"堤岸景观的设计原则和建设方案进行了探讨。

摘要：针对轴向分级再燃喷嘴,运用冷态粒子图像速度分析仪和火焰自发光CH基拍摄等试验研究方法,探究动量通量比变化时,横流与射流掺混、射流火焰以及污染物排放的变化规律。结果表明:动量通量比的变化对横流与射流的掺混和火焰位置影响较大;掺混强度和射流速度共同作用导致CO体积分数随动量通量比的增大呈现先降低后上升的趋势;动量通量比的增大会导致回流强度和射流火焰主要反应区位置发生变化,进而导致NO体积分数呈现增加的趋势;对于特定的再燃喷嘴燃烧,存在恰当的动量通量比,使得燃烧室壁面不受火焰冲刷,且污染物排放维持在较低水平。

摘要：克隆了黑木耳(Auricularia auricular-judae)内切葡聚糖酶(endoglucanase)基因并进行序列分析,此外,在大肠杆菌BL21(DE3)中成功表达。研究基于前期测得的黑木耳转录组数据,同时结合基因组数据(GenBank登录号为NEKD00000000.1),筛选到黑木耳内切葡聚糖酶基因序列并设计特异引物,以黑木耳菌丝总RNA为模板,采用RT-PCR技术克隆黑木耳内切葡聚糖酶基因cDNA全长,命名为Aa-eg,构建了重组原核表达载体pET32a-Aa-eg并成功在大肠杆菌中表达。序列分析表明,cDNA全长为1242bp,编码413个氨基酸,预测该蛋白分子量为43.59ku,理论等电点为4.42,存在信号肽。由于pET-32a载体包含20.0ku的标签,SDS-PAGE分析在45.0ku和66.2ku之间出现目的蛋白条带,与理论预期值大小一致。通过对黑木耳内切葡聚糖酶基因的克隆及分析,为进一步揭示黑木耳内切葡聚糖酶基因功能奠定基础。

摘要：计算机辅助虚拟筛选是药物分子设计领域的一项重要技术,已被广泛应用到新药研发早期先导化合物发现过程中。基于上述背景,在药物化学实验中,为了提高制药工程专业学生对天然产物构效关系的理解,开设了消渴丸中活性成分虚拟筛选的实验项目。学生通过上机操作分子对接软件,针对特定靶标,学习从有活性的混合成分中虚拟筛选先导化合物的方法,并且能够从微观可视化的角度,深刻理解药物结构和活性靶点间形状匹配、相互作用匹配才能发挥作用。在虚拟实验计算结果分析中,学生通过查阅文献,进一步探讨计算结果与实验研究的关联性。本实验使学生能够意识到传统的中草药是药物研发的巨大资源,进而培养学生在新药开发中科学的思维能力和分析解决问题的能力。

摘要：提出了利用有线通信技术实现电力隧道监控系统的配置原则,设计了一种电力隧道综合监控方案,解决了电力隧道内各种环境、温度等综合监控问题。通过具体实例进行验证,实现了对电力安全运行状态的综合监控。