摘要：Animal models are increasingly gaining values by cross-comparisons of response or resistance to clinical agents used for ***,many disease mechanisms and drug effects generated from animal models are not transferable to *** address these issues,we developed SysFinder（http：//***/SysFinder）,a platform for scientists to find appropriate animal models for translational *** offers a ＂topic-centered＂ approach for systematic comparisons of human genes,whose functions are involved in a specific scientific topic,to the corresponding homologous genes of animal *** topic can be a certain disease,drug,gene function or biological *** calculates multi-level similarity indexes to evaluate the similarities between human and animal models in specified scientific ***,SysFinder offers species-specific information to investigate the differences in molecular mechanisms between humans and animal ***,SysFinder provides a userfriendly platform for determination of short guide RNAs（sgRNAs） and homology arms to design a new animal *** studies illustrate the ability of SysFinder in helping experimental *** is a useful platform for experimental scientists to carry out their research in the human molecular mechanisms.