摘要：目的探讨神经导航辅助下手术治疗脑深部肿瘤的方法及其疗效。方法对60例脑深部肿瘤患者实施神经导航辅助手术治疗,个体化设计手术切口,术中对肿瘤及其周围关系进行精准判断,动态监测肿瘤切除程度,观察术后肿瘤影像切除率及临床症状改善情况。结果 35例胶质瘤中,34例达到影像学全部切除,1例为次全切除;2例转移瘤获得影像学全切;其余良性肿瘤均获得全部切除。术后临床症状改善55例,无变化4例,恶化1例。结论神经导航能精确定位脑深部肿瘤,合理设计手术方案,降低手术并发症。

摘要：Objective To develop RT-nPCR assays for amplifying partial and complete VP1 genes of human enteroviruses(HEVs)from clinical samples and to contribute to etiological surveillance of HEV-related *** A panel of RT-nPCR assays,consisting of published combined primer pairs for VP1 genes of HEV A–C and in-house designed primers for HEV-D,was established in this *** sensitivity of each RT-nPCR assay was evaluated with serially diluted virus stocks of five serotypes expressed as CCID50 perμL and copies perμL,and the newly established methods were tested in clinical specimens collected in recent *** The sensitivity of RT-nPCR assays for amplifying partial VP1 gene of HEVs was 0.1 CCID50 perμL and 10 virus copies perμL,and for the complete VP1 gene was 1 CCID50 perμL and 100 virus copies perμL,using serially-diluted virus stocks of five *** a proof-of-concept,25 serotypes were identified and complete VP1 sequences of 23 serotypes were obtained by this system among 858 clinical specimens positive for HEVs during the past eight surveillance *** This RT-nPCR system is capable of amplifying the partial and complete VP1 gene of HEV A–D,providing rapid,sensitive,and reliable options for molecular typing and molecular epidemiology of HEVs in clinical specimens.

摘要：To solve the topology optimization of complicated multi-objective continuous/discrete design variables in aircmit structure design, a Parallel Pareto Genetic Algorithm （PPGA） is presented based on grid platform in this paper. In the algorithm, the commercial finite element analysis （FEA） software is integrated as the calculating tool for analyzing the objective functions and the filter of Pareto solution set based on weight information is introduced to deal with the relationships among all objectives. Grid technology is utilized in PPGA to realize the distributed computations and the user interface is developed to realize the job submission and job management locally/remotely. Taking the aero-elastic tailoring of a composite wing for optimization as an example, a set of Pareto solutions are obtained for the decision-maker. The numerical results show that the aileron reversal problem can be solved by adding the limited skin weight in this system. The algorithm can be used to solve complicated topology optimization for composite structures in engineering and the computation efficiency can be improved greatly by using the grid platform that aggregates numerous idle resources.

摘要：A new method to obtain supercontinuum(SC) source for multiplex coherent anti-stokes Raman scattering (CARS) microscopy is proposed. The nonlinear propagation in photonic-crystal fibers (PCF) of femtosecond pulse laser with central wavelength at 800.9 nm is studied with scalar wave theory. Based on the incident laser power and dispersion of PCF, super broadband source for multiplex CARS microscopy is designed.

摘要：We propose a new 3D inversion scheme to invert the near-and transition-zone data of CSAMT with topography *** this new method,the earth was discretized into unstructured tetrahedra to fit the ragged topography and the vector fi nite-element method was adopted to obtain precise responses and good *** simulate the attitude and shape of the transmitter,we divided a long-grounded transmitter into dipoles and integrated these dipoles to obtain good responses in the near-and transition-fi eld ***,we designed an L2 norm-based objective functional and applied a standard quasi-Newton method as the optimization method to solve the inverse problem and guarantee steady *** tested our 3D inversion method first on synthetic data and then on a field dataset acquired from select sites near changbai Mountain,*** both tests,the new inversion algorithm achieved excellent fitting between the predicted and observed data,even in near-and transition-fi eld zones,and the inversion results agreed well with the true *** fi ndings reveal that the proposed algorithm is eff ective for 3D inversion of CSAMT data.

摘要：目的:建立一种较为快速和快速确定非均匀岩土材料渗透系数的方法。创新点:建立了一种可以从图像到数值模型的数字图像方法:通过拍照、CT等手段获取岩土材料的图像,进而通过数值分析确定等效参数。方法:1.将采集到彩色图像从RGB空间转化到HSI空间,选取识别度较高的空间进行二值化处理;2.获取二值化图像后采用邻域标记算法标记,结合本文提出的算法提取边界(图9和10);3.结合边界修正算法对锯齿状边界进行修正(图11);4.确定表征细观几何模型(图12和表1);5.绘制网格开展数值分析,确定宏观参数。结论:1.基于数值图像的非均匀岩土材料渗透系数确定方法可以较为准确地估算渗透系数,可以为工程设计提供初步依据。2.非均匀岩土材料具有明显的尺寸效应,随着尺寸增加,渗透率的变化逐渐趋于稳定;当材料视为岩石和土体的二元介质时,两种性质差异在10倍以内对宏观特性的影响较大,大于10倍之后影响减弱。3.岩土材料渗透率随着内部块石含量的增加而减小,但是内部块石的形态对渗透率也有一定的影响。

摘要：在功率半导体市场中,绝缘栅双极型晶体管(Insulated gate bipolar transistor,IGBT)和碳化硅金属氧化物半导体场效应管(Silicon carbide metal-oxide-semiconductor field-effect transistor,SiC MOSFET)具有出色的耐压性与频率特性,逐渐取代了传统的MOSFET。为了提高IGBT和SiC MOSFET驱动电路的可靠性,设计了一款光耦隔离式栅极驱动芯片,通过协同设计光探测器与驱动电路,从而实现单片集成。使用Silvaco软件对光探测器进行了仿真。仿真结果显示:光探测器对800 nm波长红外光的响应度约为0.277 A/W,-3 dB带宽约为90 MHz。进一步对光耦的光学结构进行优化设计,实现了控制端与后端高压驱动电路的有效隔离,从而解决了串扰问题。使用Maxchip 0.18μm 40 V BCD工艺进行流片,并对封装芯片进行测试。在光源输入电流为10 mA、芯片供电电压为12~40 V、输入信号频率为20 kHz的测试条件下,芯片的传播延时仅为98 ns。

摘要：为了获得更有利于驾驶人驾驶汽车的变角传动比,以便提高线控转向汽车的操纵性能,研究了汽车线控转向的变角传动比特性。从变角传动比对转向特性的影响入手,通过分析相关的操纵稳定性客观评价指标,确定以横摆角速度增益和转向灵敏度作为变角传动比特性的设计依据;高速段以侧向加速度增益替代转向灵敏度作为变角传动比特性的设计依据,中速段将横摆角速度增益作为设计依据,低速段的变角传动比特性通过主观试验确定,提出了具有变转向增益的变角传动比特性的设计方法。结果表明:变增益方法能够降低驾驶人忙碌程度,提高汽车的路径跟踪性能及行车安全性,改善汽车的操纵稳定性。

摘要：在考虑建设试验台架经济性的前提下,缩小比例的单项和整体效应试验台架对研究和开发大型先进压水堆核电站及其分析验证程序都具有重要意义。非能动安全壳冷却系统(PCS)壳外空气流道内的自然循环在安全壳非能动冷却性能中发挥着重要的作用。本文从自然循环的数学模型出发,推导出了单项和整体效应试验台架的比例设计方法。在给定壳内热流密度的条件下,通过PCCSAP-3D程序对CAP1400非能动安全壳的2/5比例单项效应试验理想比例台架(ISF)进行模拟。结果表明,本比例分析与设计方法以及在降低高度台架上模拟自然循环是可行的。

摘要：叙述了软X射线波段多层膜透射式起偏器和检偏器的设计原理,提出了设计准则,通过该准则设计的多层膜偏振元件能够同时满足具有较大的光通量和偏振度要求.同时还优化了不同膜厚比情况下软X射线多层膜偏振元件的性能,讨论了在多层膜制作过程中,由于表界面粗糙度和扩散的不同对元件性能的影响,这些工作为制作软X射线多层膜透射式起偏器和检偏器提供了设计基础.