摘要：Cardiovascular diseases are a group of disorders of the heart and blood vessels,primarily including coronary heart disease,stroke,and other *** is the world’s leading cause of death,and its incidence is increasing *** is a major risk factor for cardiovascular *** signaling comprises a series of highly conservative cascading events controlling fundamental biological *** signaling pathways include the canonical Wnt pathway(or Wnt/β-catenin pathway),the non canonical planar cell-polarity pathway,and the non-canonical calcium-dependent *** Wnt signaling promotes cell proliferation and differentiation,cardiac malformations,various malignancies,so drugs targeting Wnt signaling play a great therapeutic ***/β-catenin pathway is involved in the occurrence and development of cardiovascular diseases such as atherosclerosis and stroke by regulating cell proliferation,migration,apoptosis,blood-brain barrier permeability,inflammation,oxidative stress,and immune *** on the latest research progress,this review summarizes the role of Wnt/β-catenin signaling in cardiovascular diseases,in order to provide new ideas for the prevention and treatment of cardiovascular diseases.

摘要：民间歌谣是民心的社会艺术表达,在街头巷尾广为传唱。清末民初的张家口地区有大量的民间歌谣被保留下来,内容涉及时政、社会、婚姻和家庭等各个方面,对研究地方文化具有重要意义。

摘要：张家口地区文化产业整体水平较低,尚未形成完整的产业链条和有效的价值评价体系。作为文化产业开发链条中重要的内容,饮食习俗文化资源、建筑文化资源、休闲娱乐资源、地方艺术特色产品等民风民俗资源的产业价值与开发研究,有利于张家口的社会经济发展。

摘要：清廷移察哈尔部游牧于宣府、大同边外地,壩内壩外分置农田牧厂,呈民族杂居之局面。作为控制西北的重镇,察哈尔布有重兵,台站林立,非高官无以治之。清乾隆二十六年,政府设察哈尔都统,统率八旗驻防官兵,管理察哈尔游牧,同时署理张家口理事同知。都统之设立,既可发挥震慑要塞之功,又达到维稳地方之效,是察地设省前的重要一步。对察哈尔都统的考察,是分析地方省治建设轨迹的一把钥匙和重要内容。

摘要：张家口历史悠久,文化资源丰厚。构建整合发展模式是变张家口文化资源优势为文化产业优势的必由之路。以"整合"为切入点,从文化资源的内部整合、文化资源与旅游业的整合、文化资源与广播电视业的整合、文化资源与互联网的整合等方面探寻张家口文化资源产业化的有效途径。

摘要：针对侧重产品设计各阶段宏观布局原则制定、忽略布局合理性及其进化分析技术研究的现状,提出了一种基于细粒度约束关联网络模型的模块化设计方法。从布局规划及其协同进化的角度,给出了此方法的技术框架和闭环流程框架。研究了基于细粒度约束关联网络模型建立产品族模型的方法。探讨了基于细粒度、多视图产品族模型实现模块划分的分析技术和算法。研究了其设计过程调度方法,并提出了基于过程冲突定位和优化细粒度产品族模型的技术方法。通过在某型号发动机模块化设计中的应用,验证了所提出方法的合理性和有效性。

摘要：本文分析了"城中村"非正规部门的特征和形成原因,指出快速工业化和城市化、正规供给渠道不畅、规划的缺失、管理的不到位等因素是目前深圳非正规部门主要集中在"城中村"的主要原因,由此引发对蔡屋围的综合整治和渔民村的全面改造两种改造模式的反思。从宏观看,现有改造多是从实施规划的角度考虑,而规划往往注重物质规划、轻社会因素,这种重物质景观的改造模式过于简单化;从房地产开发的角度看,"城中村"村民出租房屋的非正规经济活动是一种房地产开发行为,渔民村的全面改造还不能满足低收入群体的住房需求,蔡屋围的综合整治模式应是主体改造模式,不同改造模式可以同步推进;从社区的角度看,"城中村"属于一种类型的社区,"城中村"改造应在社区规划的指导下进行。最后,对如何通过"城中村"改造使非正规部门正规化和社区规划等问题进行了思考,提出"城中村"改造可以将村民视为房地产开发的主体之一,将其纳入正规房地产市场体系,将社区规划纳入城市规划体系。

摘要：在轮式和履带式机器人的基础上,设计开发了一种新的管内移动机器人.机器人的3组驱动轮沿圆周方向120°均布,在轴向截面内,前后两组驱动轮布置在同一组平行四边形机构上,驱动电动机通过蜗轮蜗杆副驱动3组驱动轮,调节电动机通过滚珠丝杠螺母副和压力传感器使3组驱动轮始终以稳定的正压力紧贴在管道内壁,使机器人具有充裕并且稳定的牵引力.该机器人机构紧凑,工作可靠,适用于管径为 400～650mm的管道.

摘要：A conceptual design of using novel telescopic piles to position a multi-modular very large floating structure(VLFS),which is supposed to be severed as a movable floating airport,is *** telescopic piles can automatically plug in the soil to resist the environmental loads and pull out from the soil to evacuate or move on to the next operational *** feasibility demonstration of the conceptual design includes two parts:function verification and structure *** the latter part of the conceptual design,a time-domain structural analysis is firstly conducted by using Abaqus *** simulation results suggest that the preliminary structure scheme is not optimum due to the insufficient structure utilization,although both structure safety of the piles and positioning accuracy are *** realize a cost reduction of construction and installation,a Genetic Algorithm-Finite Element Analysis(GA-FEA)method is employed to perform structural *** optimization,31 percent of the weight of each pile is reduced and higher structure utilization is *** difference of the self-weight and allowable buoyancy of a single module(SMOD)of a semisubmersible-type VLFS is much larger than the weight of the *** with the function verification in our previous work,the conceptual design of using the novel telescopic pile to position VLFS is demonstrated to be feasible.

摘要：为研究小反刍兽疫病毒H基因过表达后对病毒增殖的影响,根据G en Bank中小反刍兽疫病毒疫苗株Nigeria 75/1 H基因序列,设计1对引物扩增H基因全长编码区序列,并将其连接至真核表达载体p EGF P-C 3上,经鉴定正确后转染CHS-20细胞,并通过R T-PCR、荧光观察及W estern-blot分别在m RNA和蛋白水平检测H基因的表达。结果表明,H基因在CHS-20细胞内得到了表达。将p EGFP-C3-PPRV H重组质粒、空载体p EGFP-C3转染CHS-20细胞,待H基因表达后,接种PPRV Nigeria 75/1,病毒增殖一定时间后,以β-actin作为内参基因,采用相对荧光定量RT-PCR法研究病毒增殖量的变化。结果表明,相对于未转染及转染空载体p EGFP-C3的细胞,转染p EGFP-C3-PPRV H重组质粒的细胞PPRV增殖量得到了提高,且差异显著(P<0.05),这说明在CHS-20细胞中过表达PPRV H基因能促进PPRV增殖。